Effects of transcranial direct current stimulation on language improvement and cortical activation in nonfluent variant primary progressive aphasia

Wang, Jie; Wu, Dongyu; Chen, Yan; Yuan, Ying; Zhang, Meikui

doi:10.1016/j.neulet.2013.06.019

Cited by 47 publications

(49 citation statements)

References 36 publications

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“…Encouraging effects of these interventions have been reported in isolated case studies, and now need to be replicated in larger systematic investigations. 156–158 …”

Section: Ppa Temporal Trajectory and Treatmentsmentioning

confidence: 99%

Primary progressive aphasia and the evolving neurology of the language network

et al. 2014

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Primary progressive aphasia (PPA) is caused by selective neurodegeneration of the language-dominant cerebral hemisphere; a language deficit initially arises as the only consequential impairment and remains predominant throughout most of the course of the disease. Agrammatic, logopenic and semantic subtypes, each reflecting a characteristic pattern of language impairment and corresponding anatomical distribution of cortical atrophy, represent the most frequent presentations of PPA. Such associations between clinical features and the sites of atrophy have provided new insights into the neurology of fluency, grammar, word retrieval, and word comprehension, and have necessitated modification of concepts related to the functions of the anterior temporal lobe and Wernicke’s area. The underlying neuropathology of PPA is, most commonly, frontotemporal lobar degeneration in the agrammatic and semantic forms, and Alzheimer disease (AD) pathology in the logopenic form; the AD pathology often displays atypical and asymmetrical anatomical features consistent with the aphasic phenotype. The PPA syndrome reflects complex interactions between disease-specific neuropathological features and patient-specific vulnerability. A better understanding of these interactions might help us to elucidate the biology of the language network and the principles of selective vulnerability in neurodegenerative diseases. We review these aspects of PPA, focusing on advances in our understanding of the clinical features and neuropathology of PPA and what they have taught us about the neural substrates of the language network.

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“…Encouraging effects of these interventions have been reported in isolated case studies, and now need to be replicated in larger systematic investigations. 156–158 …”

Section: Ppa Temporal Trajectory and Treatmentsmentioning

confidence: 99%

Primary progressive aphasia and the evolving neurology of the language network

et al. 2014

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“…The paradigm resulted in improved auditory word comprehension, picture naming, oral word reading, and word repetition (Wang et al, 2013). More recently, Tsapkini and colleagues explored the effects of anodal tDCS of the left inferior frontal gyrus paired with a behavioral spelling intervention in patients with primary progressive aphasia.…”

Section: Tms and Tdcs In The Treatment Of Ppamentioning

confidence: 99%

Non-invasive Brain Stimulation in the Treatment of Post-stroke and Neurodegenerative Aphasia: Parallels, Differences, and Lessons Learned

Norise

Hamilton

2017

Front. Hum. Neurosci.

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Numerous studies over the span of more than a decade have shown that non-invasive brain stimulation (NIBS) techniques, namely transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), can facilitate language recovery for patients who have suffered from aphasia due to stroke. While stroke is the most common etiology of aphasia, neurodegenerative causes of language impairment—collectively termed primary progressive aphasia (PPA)—are increasingly being recognized as important clinical phenotypes in dementia. Very limited data now suggest that (NIBS) may have some benefit in treating PPAs. However, before applying the same approaches to patients with PPA as have previously been pursued in patients with post-stroke aphasia, it will be important for investigators to consider key similarities and differences between these aphasia etiologies that is likely to inform successful approaches to stimulation. While both post-stroke aphasia and the PPAs have clear overlaps in their clinical phenomenology, the mechanisms of injury and theorized neuroplastic changes associated with the two etiologies are notably different. Importantly, theories of plasticity in post-stroke aphasia are largely predicated on the notion that regions of the brain that had previously been uninvolved in language processing may take on new compensatory roles. PPAs, however, are characterized by slow distributed degeneration of cellular units within the language system; compensatory recruitment of brain regions to subserve language is not currently understood to be an important aspect of the condition. This review will survey differences in the mechanisms of language representation between the two etiologies of aphasia and evaluate properties that may define and limit the success of different neuromodulation approaches for these two disorders.

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“…These appeared to show significant improvement in some language functions in the absence of adverse effects (Cotelli et al, 2014; Tsapkini, Frangakis, Gomez, Davis, & Hillis, 2014; Wang, Wu, Chen, Yuan, & Zhang, 2013). A case study carried out by Wang et al (2013) on a patient with naPPA demonstrated that five days of anodal tDCS over the left inferior frontal gyrus (IFG) and the left posterior peri-Sylvian region led to improvements in four subtests of the Psycholinguistic Assessment in Chinese Aphasia (PACA) battery. Recent work by Cotelli et al (2014), also focusing on non-fluent patients, found improvements in naming abilities after two weeks of daily tDCS over the left DLPFC combined with concurrent language therapy in 8 patients.…”

Section: Introductionmentioning

confidence: 96%

Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study

et al. 2016

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Primary progressive aphasia (PPA) is a neurodegenerative condition characterized by gradual deterioration of language function. We investigated whether two weeks of daily transcranial direct current stimulation (tDCS) treatment would improve language abilities in six people with a non-fluent form of PPA. tDCS was applied in an unblinded trial at an intensity of 1.5 mA for 20 min/day over 10 days. At the time of stimulation, patients were engaged in narrating one of several children’s wordless picture stories. A battery of neuropsychological assessments was administered four times: at baseline, immediately following the 2-week stimulation period, and then 6-weeks and 12-weeks following the end of stimulation. We observed improvement in linguistic performance in the domains of speech production and grammatical comprehension. Our encouraging results indicate that larger, sham-controlled studies of tDCS as a potential intervention for PPA are warranted.

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Effects of transcranial direct current stimulation on language improvement and cortical activation in nonfluent variant primary progressive aphasia

Cited by 47 publications

References 36 publications

Primary progressive aphasia and the evolving neurology of the language network

Primary progressive aphasia and the evolving neurology of the language network

Non-invasive Brain Stimulation in the Treatment of Post-stroke and Neurodegenerative Aphasia: Parallels, Differences, and Lessons Learned

Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study

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