Effects of tranexamic acid on the amount of bleeding following vaginal delivery and its adverse effects: a double-blind placebo controlled randomized clinical trial

Kashanian, Maryam; Dadkhah, Farideh; Tabatabaei, Nasim; Sheikhansari, Narges

doi:10.1080/14767058.2021.1888911

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…A multicenter, double‐blinded, randomized control trial evaluated whether the use of TXA before vaginal delivery resulted in reduced postpartum hemorrhage. The results of this study demonstrated a significantly lower incidence of calculated estimated blood loss, greater than 1000 ml, or the need for red‐cell transfusion 14 …”

Section: Clinical Applications Of Txamentioning

confidence: 64%

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Tranexamic acid: Beyond antifibrinolysis

et al. 2022

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Tranexamic acid (TXA) is a popular antifibrinolytic drug widely used in hemorrhagic trauma patients and cardiovascular, orthopedic, and gynecological surgical patients. TXA binds plasminogen and prevents its maturation to the fibrinolytic enzyme plasmin. A number of studies have demonstrated the broad life‐saving effects of TXA in trauma, superior to those of other antifibrinolytic agents. Besides preventing fibrinolysis and blood loss, TXA has been reported to suppress posttraumatic inflammation and edema. Although the efficiency of TXA transcends simple inhibition of fibrinolysis, little is known about its mechanisms of action besides the suppression of plasmin maturation. Understanding the broader effects of TXA at the cell, organ, and organism levels are required to elucidate its potential mechanisms of action transcending antifibrinolytic activity. In this article, we provide a brief review of the current clinical use of TXA and then focus on the effects of TXA beyond antifibrinolytics such as its anti‐inflammatory activity, protection of the endothelial and epithelial monolayers, stimulation of mitochondrial respiration, and suppression of melanogenesis.

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Section: Clinical Applications Of Txamentioning

confidence: 64%

“…The results of this study demonstrated a significantly lower incidence of calculated estimated blood loss, greater than 1000 ml, or the need for red-cell transfusion. 14…”

Section: Obstetrics and Gynecologymentioning

confidence: 99%