Effects of tramadol on myocardial ischemia-reperfusion injury

Bilir, Ayten; Erkasap, Nilüfer; Köken, Tülay; Güleç, Sacit; Kaygisiz, Ziya; Tanriverdi, Belkıs; Kurt, İmran

doi:10.1080/14017430701227747

Cited by 29 publications

(23 citation statements)

References 15 publications

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“…MDA levels were significantly higher in I/R group as compared to perconditioning, tramadol and Per+T, suggesting that they were efficient to maintain a higher antioxidant defense which allows further destruction of oxygen free radicals, reducing lipid peroxidation mediated by these reactive species released from the kidney tissue 16 .…”

Section: ■ Discussionmentioning

confidence: 90%

“…Furthermore, these results suggest that administration of tramadol, a centrally acting analgesic agent, may induce a renal protective effect against I/R oxidative injury. Many reports on literature describe beneficial use of this substance on experimental models such as transient forebrain ischemia 19 , myocardial 16 and skeletal muscle I/R 12 .…”

Section: ■ Discussionmentioning

confidence: 99%

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Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

et al. 2017

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Section: ■ Discussionmentioning

confidence: 90%

Section: ■ Discussionmentioning

confidence: 99%

Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

et al. 2017

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“…( 7 , 8 ) Recent research discloses that tramadol decreases lipid peroxidation and regulates noradrenalin uptake, and, therefore, these therapeutic properties are used for the management of myocardial ischemia. ( 9 ) …”

Section: Introductionmentioning

confidence: 99%

“…( 7 , 8 ) Um estudo recente revelou que o tramadol diminui a peroxidação lipídica e regula a captação de noradrenalina, e, por conseguinte, essas propriedades terapêuticas são usadas para o manejo da isquemia miocárdica. ( 9 ) …”

Section: Introductionunclassified

Effect of tramadol on lung injury induced by skeletal muscle ischemia-reperfusion: an experimental study

et al. 2013

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OBJECTIVE: To determine whether tramadol has a protective effect against lung injury induced by skeletal muscle ischemia-reperfusion. METHODS: Twenty Wistar male rats were allocated to one of two groups: ischemia-reperfusion (IR) and ischemia-reperfusion + tramadol (IR+T). The animals were anesthetized with intramuscular injections of ketamine and xylazine (50 mg/kg and 10 mg/kg, respectively). All of the animals underwent 2-h ischemia by occlusion of the femoral artery and 24-h reperfusion. Prior to the occlusion of the femoral artery, 250 IU heparin were administered via the jugular vein in order to prevent clotting. The rats in the IR+T group were treated with tramadol (20 mg/kg i.v.) immediately before reperfusion. After the reperfusion period, the animals were euthanized with pentobarbital (300 mg/kg i.p.), the lungs were carefully removed, and specimens were properly prepared for histopathological and biochemical studies. RESULTS: Myeloperoxidase activity and nitric oxide levels were significantly higher in the IR group than in the IR+T group (p = 0.001 for both). Histological abnormalities, such as intra-alveolar edema, intra-alveolar hemorrhage, and neutrophil infiltration, were significantly more common in the IR group than in the IR+T group. CONCLUSIONS: On the basis of our histological and biochemical findings, we conclude that tramadol prevents lung tissue injury after skeletal muscle ischemia-reperfusion.

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“…Similar side effects were exhibited by bradykinin [94]. Our research group tested tramadol on CABG patients, an opioid that also shows the serotonin effect, for which cardioprotective effects were demonstrated as well [95, 96]. Conversely, however, in this study tramadol increased postoperative serum levels of troponin I quite significantly.…”

Section: Pharmacological Cardioprotectionmentioning

confidence: 55%

Adjuvant Cardioprotection in Cardiac Surgery: Update

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Gabbasov

et al. 2014

BioMed Research International

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Cardiac surgery patients are now more risky in terms of age, comorbidities, and the need for complex procedures. It brings about reperfusion injury, which leads to dysfunction and/or loss of part of the myocardium. These groups of patients have a higher incidence of postoperative complications and mortality. One way of augmenting intraoperative myocardial protection is the phenomenon of myocardial conditioning, elicited with brief nonlethal episodes of ischaemia-reperfusion. In addition, drugs are being tested that mimic ischaemic conditioning. Such cardioprotective techniques are mainly focused on reperfusion injury, a complex response of the organism to the restoration of coronary blood flow in ischaemic tissue, which can lead to cell death. Extensive research over the last three decades has revealed the basic mechanisms of reperfusion injury and myocardial conditioning, suggesting its therapeutic potential. But despite the enormous efforts that have been expended in preclinical studies, almost all cardioprotective therapies have failed in the third phase of clinical trials. One reason is that evolutionary young cellular mechanisms of protection against oxygen handling are not very robust. Ischaemic conditioning, which is among these, is also limited by this. At present, the prevailing belief is that such options of treatment exist, but their full employment will not occur until subquestions and methodological issues with the transfer into clinical practice have been resolved.

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Effects of tramadol on myocardial ischemia-reperfusion injury

Abstract: Tramadol provides a cardioprotective effect against myocardial ischemia-reperfusion in isolated rat heart.

Cited by 29 publications

References 15 publications

Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

Effect of tramadol on lung injury induced by skeletal muscle ischemia-reperfusion: an experimental study

Adjuvant Cardioprotection in Cardiac Surgery: Update

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