Effects of traditional Chinese medicine on bone remodeling during orthodontic tooth movement

Yuan, Weili; Wang, Xuxia; Zhang, Lina; Jin, Sun; Zhang, Jun

doi:10.1016/j.jep.2011.09.003

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…As previously reported, prolongation of the application period of the orthodontic force increased both the amount of the experimental tooth movement of the maxillary first molar and the expression of mature osteoclasts on the mesial side of the distopalatal root of the maxillary right first molar (Table 2 and Fig. 2, J-L) (Shibazaki et al 2009;Wang et al 2012), and these morphological features are significantly correlated with orthodontic force-induced temporal alterations of the threshold for inducing the jaw-opening reflex with right-side stimulation (Fig. 2, M and N).…”

Section: Effects Of Prolonged Application Of Orthodontic Force On Jaw-opening Reflex Excitability and Emg Parameterssupporting

confidence: 69%

Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability

Sasaki

Hasegawa

Adachi

et al. 2017

Journal of Neurophysiology

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The impairment of orofacial motor function during orthodontic treatment needs to be addressed, because most orthodontic patients experience pain and motor excitability would be affected by pain. In the present study, the temporal alteration of the jaw-opening reflex excitability was investigated to determine if orthodontic treatment affects orofacial motor function. The excitability of jaw-opening reflex evoked by electrical stimulation on the gingiva and recorded bilaterally in the anterior digastric muscles was evaluated at 1 (D1), 3 (D3), and 7 days (D7) after orthodontic force application to the teeth of right side; morphological features (e.g., osteoclast genesis and tooth movement) were also evaluated. To clarify the underlying mechanism of orthodontic treatment-induced alteration of orofacial motor excitability, analgesics were administrated for 1 day. At D1 and D3, orthodontic treatment significantly decreased the threshold for inducing the jaw-opening reflex but significantly increased the threshold at D7. Other parameters of the jaw-opening reflex were also evaluated (e.g., latency, duration and area under the curve of anterior digastric muscles activity), and only the latency of the D1 group was significantly different from that of the other groups. Temporal alteration of the jaw-opening reflex excitability was significantly correlated with changes in morphological features. Aspirin (300 mg·kg·day) significantly increased the threshold for inducing the jaw-opening reflex, whereas a lower dose (75-150 mg·kg·day) of aspirin or acetaminophen (300 mg·kg·day) failed to alter the jaw-opening reflex excitability. These results suggest that an increase of the jaw-opening reflex excitability can be induced acutely by orthodontic treatment, possibly through the cyclooxygenase activation. It is well known that motor function is affected by pain, but the effect of orthodontic treatment-related pain on the trigeminal motor excitability has not been fully understood. We found that, during orthodontic treatment, trigeminal motor excitability is acutely increased and then decreased in a week. Because alteration of trigeminal motor function can be evaluated quantitatively by jaw-opening reflex excitability, the present animal model may be useful to search for alternative approaches to attenuate orthodontic pain.

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Section: Effects Of Prolonged Application Of Orthodontic Force On Jaw-opening Reflex Excitability and Emg Parameterssupporting

confidence: 69%

Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability

Sasaki

Hasegawa

Adachi

et al. 2017

Journal of Neurophysiology

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“…The rats were anaesthetised with an intraperitoneal injection of 2% pentobarbital, and the extremities and head were fixed. Then, a Ni-Ti closed coil spring (0.012 inches in diameter, GRIMED Medical (Beijing) Co., Ltd) with an active length of 4 mm was placed between the upper incisor and the upper right first molar, and fixed with 0.2 mm diameter ligature wire around both teeth using a bio-glue as described previously [12][13][14] (Figure S1). Closed-coil nickel-titanium springs were used to apply 50 and 100 g of orthodontic forces, respectively.…”

Section: Experimental Tooth Movementmentioning

confidence: 99%

A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement

Shen

Ying

et al. 2022

Aust Endodontic J

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Investigation on the effect of Piezo1 on periodontal tissue and periodontal ligament fibroblasts (PDLFs) under mechanical stress and the underlying mechanism. The orthodontic tooth movement rat model was established via an orthodontic spiral tension spring. PDLFs were cultured and subjected to 2.0 g/cm2 static compressive loading. Blocked the Piezo1 via Piezo1 inhibitor, GsMTx4. TUNEL staining and flow cytometry determined the apoptosis rate of periodontal tissue and PDLFs in rats. Expression of Piezo1, p‐p38 and ERK1/2 was analysed by immunofluorescence assay and western blotting. Piezo1 inhibitor GsMTx4 relieved the increased expression of Piezo1, ERK1/2 and p‐p38, and alleviated apoptosis in periodontal tissue and PDLFs under compressive loading. Piezo1 inhibition can alleviate force‐induced apoptosis and damage in rats' periodontal tissue and PDLFs, and regulate the p38/ERK1/2 signalling pathway.

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“…The herb, Drynaria, is referred to in China as GuSuiBu, literally meaning "mend broken bones". [11] Various phytoconstituents like 3,4-dihydroxybenzoic acid, fridelin, epifriedelinol, coumarins has been isolated from the plant and these bioactive compounds responsible for its antidermatophytic, antimicrobial, anti-lipidperoxidative, antiulcer, antipyretic, anti-arthritis, anti-urolithiatic and thrombolytic activities. [12] The Drynaria quercifolia rhizome extract is known to increase the alkaline phosphatase (ALP) activity and accelerate synthesis of proteoglycans.…”

Section: Drynaria Quercifolia Plant Extract As a Bone Regenerative Mamentioning

confidence: 99%

Drynaria Quercifolia Plant Extract as A Bone Regenerative Material in The Treatment of Periodontal Intrabony Defects: Clinical And Radiographic Assessment

Pawar¹,

Chandrashekar²,

Mishra³

et al. 2017

IOSR JDMS

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Effects of traditional Chinese medicine on bone remodeling during orthodontic tooth movement

Cited by 9 publications

References 19 publications

Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability

Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability

A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement

Drynaria Quercifolia Plant Extract as A Bone Regenerative Material in The Treatment of Periodontal Intrabony Defects: Clinical And Radiographic Assessment

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