Effects of Topiramate on the Chronic Constriction Injury Model in the Rat

Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents

“…Other anticonvulsants share this action (Hunter et al, 1997;Bischofs et al, 2004;Benoliel and Eliav E Tal, 2006). Furthermore, topimarate and tramadol, have shown synergistic action in models of pain caused by spinal nerve ligation and in the hot plate test (Codd et al, 2008).…”

“…Furthermore, topimarate and tramadol, have shown synergistic action in models of pain caused by spinal nerve ligation and in the hot plate test (Codd et al, 2008). Clinical experiments have shown topiramate's analgesic effects in painful conditions, such as trigeminal neuralgia, migraine and diabetic neuropathy (Guay 2003;Benoliel and Eliav E Tal, 2006). However, other authors have shown the ineffectiveness of topiramate in models of acute pain in rats (Shannon et al, 2005).…”

“…Topiramate also proves effective after 8 weeks of treatment in humans (Donofrio et al, 2005). Other evidence shows that topiramate promotes some degree of neural regeneration, probably through neuropeptide Y (NPY) expression in the dorsal root ganglion, although this has not been confirmed by other authors (Benoliel and Eliav E Tal, 2006). In addition, topiramate has shown neuroprotective action in animal models of cerebral ischemia and epileptic conditions (Kudin et al, 2004).…”

“…Based on the results obtained, it seems topiramate does not act on TRPV1 receptors. (Glauser 1999;Benoliel and Eliav E Tal, 2006).…”

Topiramate attenuates early brain injury following subarachnoid haemorrhage in rats via duplex protection against inflammation and neuronal cell death

“…Moreover, EBI is the primary cause of mortality and morbidity in SAH patients, and the time point of 24 h post-SAH has been reported to be appropriate for the study of EBI (Bederson et al, 2009;Mayberg et al, 1994;Yatsushige et al, 2006). Some researchers have also reported the protective effects of TPM on a series of neural injuries, such as cerebral ischemia/reperfusion injury, epilepsy, cervical spinal cord injury, traumatic brain injury (TBI), chronic constriction injury and SAH-induced hippocampal injury, via multiple mechanisms (Benoliel et al, 2006;Gensel et al, 2012;Hoover et al, 2004;Kouzounias et al, 2011;Kudin et al, 2004;Mao et al, 2012;Seckin et al, 2009;Yang et al, 1998Yang et al, , 2000. Our present study shows the protective effect of TPM on EBI after SAH.…”