Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris

Bernstein, Joel E.; Parish, Lawrence Charles; Rapaport, Marvin J.; Rosenbaum, Marjorie Mintz; Roenigk, Henry H.

doi:10.1016/s0190-9622(86)70201-6

Cited by 175 publications

(95 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A neurogenic component for the pathophysiology of psoriasis is suggested both by clinical and experimental studies (59,244,572,573). Clinically, psoriatic lesions often have a symmetrical distribution in regions that are traumatized.…”

Section: B Psoriasismentioning

confidence: 99%

“…The so-called Koebner phenomenon in psoriasis may be initiated by the release of proinflammatory neuropeptides in the traumatized human skin (243). Investigators have also reported increased levels of neuropeptides and sensory nerves in psoriatic skin lesions, and capsaicin, a chemical that depletes neuropeptides from nerve endings, has been reported to have some therapeutic value in clearing lesions (59,244). Increased concentrations or immunoreactivity for several neuropeptides have been observed in lesional skin of patients with psoriasis (10,154,572,573,643,809).…”

Section: B Psoriasismentioning

confidence: 99%

See 1 more Smart Citation

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

552

521

View full text Add to dashboard Cite

This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

show abstract

Section: B Psoriasismentioning

confidence: 99%

Section: B Psoriasismentioning

confidence: 99%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

552

521

View full text Add to dashboard Cite

show abstract

“…An important role of neurogenic inflammation in the pathogenesis of psoriasis is substantiated by a number of observations 4 -12 : exacerbations during periods of stress, 4 marked proliferation of terminal cutaneous nerves, 6,7 upregulation of neuropeptides [substance P (SP), vasoactive intestinal peptide, calcitonin gene-related peptide (CGRP)] 6 -8 in the psoriatic plaques, therapeutic response to neuropeptide-modulating agents such as capsaicin, 9 soSupported by the Psoriasis Research Institute.…”

mentioning

confidence: 99%

Revisiting the Koebner Phenomenon

Raychaudhuri

Jiang

Raychaudhuri

2008

The American Journal of Pathology

View full text Add to dashboard Cite

Nerve growth factor (NGF) influences the key pathological events of psoriasis: keratinocyte proliferation, angiogenesis, and T-cell activation. We have systematically examined the kinetics of NGF expression, keratinocyte proliferation, and migration of T lymphocytes in the epidermis in Koebner-induced developing psoriatic plaques. In skin traumatized by the tape-stripping method (n ‫؍‬ 12), a marked up-regulation of NGF in Koebner-positive lesions (n ‫؍‬ 7) was observed 24 hours after trauma. Synthesis of NGF reached its maximum level in the 2nd week. Furthermore, cultured keratinocytes from nonlesional skin of psoriasis patients produced 10 times higher levels of NGF compared with keratinocytes from healthy individuals. To substantiate the in vivo effect of NGF secreted by keratinocytes in psoriatic plaques, we studied psoriatic plaques and normal human skin in a SCID-human skin xenograft model. The transplanted psoriatic plaques demonstrated marked proliferation of NGF-R (p75)-positive nerve fibers compared with only a few nerves in the transplanted normal human skin. Our results demonstrate that 1) in a developing psoriatic lesion, up-regulation of NGF together with keratinocyte proliferation are early events and precede epidermotropism of T lymphocytes; 2) keratinocytes in patients with psoriasis are primed to produce elevated levels of NGF; and 3) NGF synthesized by these keratinocytes is functionally active.

show abstract

“…Significantly improved reduction in scaling and erythema was observed. Burning, stinging, itching, and redness of the skin were noted by nearly half of the patients on initial applications of study medication but diminished or vanished upon continued application which suggest that topical application of capsaicin may be a useful in the treatment of psoriasis 125 . Capsaicin was successfully used in treatment of acute lipodermatosclerosis and acute lobular panniculitis in pregnant woman 126 .…”

Section: Dermatological Conditionsmentioning

confidence: 97%

Untitled

2017

IJPSR

View full text Add to dashboard Cite

Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. Natural products from plant, animal and minerals have been the basis of the treatment of human disease. Capsicum plants belongs to the family Solanaceae and kingdom Plantae, consist of 27 species, and approximately 3000 varieties. Chili peppers are used worldwide in foods for their pungent flavor, aroma, and to prolong food spoilage. With capsaicin contents ranging from zero to millions of Scoville heat units, the different varieties offer a wide range of options for people all over the world. The aim of present review is to form a short compilation of the pharmacological and toxicological potentials of this multipurpose fruit. Capsicum, has been used as anti-inflammatory, anti-diabetic, anti-cancer, anti-ulcer, anticoagulant, analgesic, anti-arthritis, immuno-modulatory, memory enhancing, pain relief, hypocholesterolaemic, hypolipidemic, hepatoprotective and antimicrobial effects. It also cause irritation to mucous membrane, inflammation and neurotoxicity. It should not be used on open wounds or abrasions, or near the eyes. It has antagonistic effects on of α-adrenergic blockers, clonidine and methyldopa.

show abstract

Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris

Cited by 175 publications

References 16 publications

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Revisiting the Koebner Phenomenon

Untitled

Contact Info

Product

Resources

About