Effects of Topical Use of β-Adrenoceptor Stimulants on Nasal Mucosa. Rhinomanometric Evaluations in Experiments with Terbutaline and KWD 2131: II. Nasal Provocation Tests with Hay Fever Patients in Asymptomatic Period

Svensson, Gunnar; Hegardt, B.; Löfkvist, Thorvald

doi:10.3109/00016488009131708

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…Hiley, Wilson & Yates (1978) reported that /J2-adrenoceptors were present in the feline capacitance vessels. In man, topical administration of isoprenaline or terbutaline results in either a variable response (McLean, Mathews, Ciarkowski, Brayton & Solomon, 1976), an increase in airway pressure (Grobler, 1966) or no effect (Cohen, 1970;Svensson, Hegardt & Lofkvist, 1980). Our results suggest that ,,-and fl2-adrenoceptors are present in the nose of the dog.…”

Section: Nasal Airway Resistancesupporting

confidence: 49%

Control of nasal vasculature and airflow resistance in the dog.

Lung¹,

Phipps²,

Wang³

et al. 1984

The Journal of Physiology

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SUMMARY1. Nasal vascular and airflow resistances have been measured in dogs, simultaneously on both sides separately.2. Vascular resistance was measured either by constant flow perfusion of the terminal branch of the maxillary artery (which supplies, via the sphenopalatine artery, the nasal septum, most of the turbinates and the nasal sinuses) or by measuring blood flow through this artery, maintained by the dog's own blood pressure.3. Airflowresistancewasassessedbyinsertingballoon-tippedendotrachealcatheters into the back of each nasal cavity via the nasopharynx, and measuring transnasal pressure at constant airflow through each side of the nose simultaneously.4. Preliminary experiments indicated that there was 5-10 % collateral anastomosis between the two sides.5. Close-arterial injection of drugs showed different patterns of response. 6. Adrenaline, phenylephrine, chlorpheniramine and low doses of prostaglandin F2a increased vascular resistance and lowered airway resistance.7. Salbutamol, methacholine and histamine lowered vascular resistance and increased airway resistance.8. Dobutamine decreased airway resistance with a small increase in vascular resistance.9. Prostaglandins E1, E2 and F2a (high dose) decreased both vascular and airway resistances.10. Substance P, eledoisin-related peptide and vasoactive intestinal polypeptide lowered vascular resistance with little change in airway resistance.11. The results are interpreted in terms of possible drug actions on precapillary resistance vessels, sinusoids and venules, and arteriovenous anastomoses. It is concluded that nasal airway resistance cannot be correlated with vascular resistance or blood flow, since the latter has a complex and ill-defined relationship with nasal vascular blood volume. M. A. LUNG AND OTHERS

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Section: Nasal Airway Resistancesupporting

confidence: 49%

Control of nasal vasculature and airflow resistance in the dog.

Lung¹,

Phipps²,

Wang³

et al. 1984

The Journal of Physiology

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“…Recently, it has been used for pharmacological testing [Borum and Mygind, 1980;Svensson, 1980;Pipkorn, 1982]. We found the sympathomimetic treat ment effective for NAR in accordance with the subjective effects on nasal obstruction reported by the patients.…”

Section: Discussionsupporting

confidence: 63%

Sympathomimetics in Nasal Allergy

Bende¹,

Laurin²

1986

ORL

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The effect of a topically administered α-adrenoceptor agonist (phenylpropanolamine) after allergen challenge was evaluated in a placebo-controlled double-blind crossover study in 10 subjects with allergic rhinitis in an asymptomatic period. The nasal airway resistance was objectively measured by anterior rhinomanometry after nasal allergen challenge. The degree of nasal blockage, secretion and the number of sneezes were registered in a score. Nasal airway resistance and the degree of blockage were found to be significantly reduced. Thus, α-adrenoceptor agonists might be used topically for symptomatic treatment of allergic rhinitis comprising mucosal congestion.

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“…The relation in anti-allergic effect between terbutaline and KWD 2131 is 1:1 in in vitro animal lung studies (36) and in vivo studies on human skin (22) and nose (39). The relation in anti-allergic effect between terbutaline and KWD 2131 is 1:1 in in vitro animal lung studies (36) and in vivo studies on human skin (22) and nose (39).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the protective Effect of a New β‐Agonist, KWD 2131, On Allergen‐Induced Bronchospasm

Hegardt¹,

Löwhagen²,

Svedmyr³

1980

Allergy

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The selective anti-allergic effect of a new beta-agonist, KWD 2131, in inhibiting allergen-provoked asthma was compared with that of placebo in a double-blind crossover study. Non-bronchodilating doses were given by inhalation to 12 asymptomatic patients with extrinsic asthma. KWD 2131 showed a marginal anti-allergic effect. A significantly better effect than that with placebo was obtained at only one time of measurement after challenge (P < 0.05). The reproducibility of the allergen challenge was also evaluated. The mean maximum decrease in FEV1 during three different allergen-challenge procedures was 37, 31, and 38%, respectively. The difference was not statistically significant.

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Effects of Topical Use of β-Adrenoceptor Stimulants on Nasal Mucosa. Rhinomanometric Evaluations in Experiments with Terbutaline and KWD 2131: II. Nasal Provocation Tests with Hay Fever Patients in Asymptomatic Period

Cited by 15 publications

References 23 publications

Control of nasal vasculature and airflow resistance in the dog.

Control of nasal vasculature and airflow resistance in the dog.

Sympathomimetics in Nasal Allergy

Evaluation of the protective Effect of a New β‐Agonist, KWD 2131, On Allergen‐Induced Bronchospasm

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