Effects of Topical Travoprost and Unoprostone on Optic Nerve Head Circulation in Normal Rabbits

Ohashi, Megumi; Mayama, Chihiro; Ishii, Kiyoshi; Araie, Makoto

doi:10.1080/02713680701531090

Cited by 11 publications

(11 citation statements)

References 34 publications

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“…Interestingly, formulation of this drug with two different preservatives showed disparate results, and more studies are needed to confirm the effect of this drug on RI. Other research groups have shown that travoprost is effective for improving blood flow, as found in the present study with travoprost BAK (25)(26)(27) . Further, in the present research, travoprost with BAK as a preservative significantly decreased RI, while travoprost with POLYQUAD did not; therefore, the preservative BAK may have some effect in this instance.…”

supporting

confidence: 79%

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Giannico¹,

Lima²,

Shaw³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Universidade Federal do Paraná, protocol #011/2011. ABSTRACTPurpose: The aim of this study was to investigate the effects of prostaglandin analogs on blood flow in the ophthalmic artery of clinically healthy rabbits. Methods: Fifty-five clinically healthy New Zealand white rabbits were divided into six groups, and the left eyes were treated for four weeks with the preservative benzalkonium chloride (BAK) only or a topical formulation of different prostaglandin analogs (bimatoprost BAK, tafluprost BAK-free, travoprost BAK, travoprost POLYQUAD, and latanoprost BAK). Color Doppler imaging was performed before and after the treatments. The mean values of the peak systolic velocity (PSV) and end diastolic velocity and the resistive index (RI) were calculated. Statistical analysis was performed to compare the differences pre-and post-treatment for each drug and post-treatment among the drugs. Results: The prostaglandin analogs did not affect PSV. Bimatoprost BAK, travoprost POLYQUAD, and latanoprost BAK did not change RI. Tafluprost BAK-free and travoprost BAK therapy resulted in similar reductions in RI. No significant differences pre-and post-treatment were found when BAK was administered alone. Conclusion:The prostaglandin analogs tafluprost BAK-free and travoprost BAK improved blood flow in the ophthalmic artery in healthy New Zealand white rabbits, which suggests that these drugs enhance the prevention of the progression the progression of glaucoma. Keywords

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supporting

confidence: 79%

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Giannico¹,

Lima²,

Shaw³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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“…; Ohashi et al. ; Sugiyama et al. ) as well as a direct neuroprotective effect on neuronal cell death (Melamed ; Mukuno et al.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa

Akiyama

Ikeda

Yoshida

et al. 2013

Acta Ophthalmologica

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ABSTRACT.Purpose: To evaluate the therapeutic effect of topical unoprostone isopropyl (unoprostone) on patients with retinitis pigmentosa (RP). Methods: Forty patients with typical forms of RP were included in the study. Seventeen of 40 patients were treated with 0.12% topical unoprostone twice daily in a randomly selected eye. Patients underwent follow-up examinations every 3 months after treatment. The efficacy of the treatment was monitored by visual acuity and visual field measurement testing using the Humphrey Field Analyzer (HFA: the central 10-2 programme). Moreover, 12 RP patients who were included this study and 12 normal subjects were evaluated in terms of their macular blood flow of both eyes after instillation of unoprostone using the laser speckle method. Results: One year after treatment, the 'macular sensitivity', calculated by HFA as the average sensitivity of the central 12 points, was preserved in the fellow eyes as well as the unoprostone-treated eyes. On the other hand, that in the eyes of the control RP patient was significantly decreased. Moreover, there were significantly greater improvements of the 'macular sensitivity' in the unoprostone-treated eyes than the fellow eyes. The change ratios of macular blood flow obtained from both RP patients and normal subjects were significantly increased in both the treated and the fellow eyes. No severe side-effects were observed.Conclusions: These results demonstrate that topical unoprostone might have a therapeutic efficacy in patients with RP as a consequence of the macular blood flow improvement as well as its direct neuroprotective effect.

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“…Latanoprost increases the optic nerve head blood flow in humans, 4,5 and travoprost increases the ocular blood flow in both humans and animals. 6,7 In addition, we reported that the PG analogues latanoprost, isopropyl unoprostone, and tafluprost induce concentration-dependent relaxation of isolated rabbit ciliary arteries. [8][9][10] Using laser speckle flowmetry, we reported that tafluprost, latanoprost, and travoprost prevent the endothelin-1 (ET-1)-induced decrease of optic nerve head ocular blood flow in rabbits.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Prostaglandin Analogues on Intracellular Ca²⁺ in Ciliary Arteries of Wild-Type and Prostanoid Receptor-Deficient Mice

Abe

Watabe²,

Takaseki³

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

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PG analogues latanoprost, isopropyl unoprostone, and tafluprost reduced the K(+)-dependent increase in [Ca(2+)](i) in isolated mouse ciliary arteries. Endothelial-derived factors and FP and EP3 receptors were not involved in the responses. The increased effectiveness of latanoprost and tafluprost in reducing [Ca(2+)](i) in EP1 and EP2 receptor-deficient arteries suggests that the PG analogues may act, at least partially, through nonprostanoid receptor pathways. For glaucoma patients, PG analogues can be selected to reduce the intraocular pressure and increase the ocular blood flow.

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Effects of Topical Travoprost and Unoprostone on Optic Nerve Head Circulation in Normal Rabbits

Cited by 11 publications

References 34 publications

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa

The Effects of Prostaglandin Analogues on Intracellular Ca²⁺ in Ciliary Arteries of Wild-Type and Prostanoid Receptor-Deficient Mice

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Effects of Topical Travoprost and Unoprostone on Optic Nerve Head Circulation in Normal Rabbits

Cited by 11 publications

References 34 publications

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa

The Effects of Prostaglandin Analogues on Intracellular Ca2+ in Ciliary Arteries of Wild-Type and Prostanoid Receptor-Deficient Mice

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The Effects of Prostaglandin Analogues on Intracellular Ca²⁺ in Ciliary Arteries of Wild-Type and Prostanoid Receptor-Deficient Mice