Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: A pilot study

Patriarca, Marisa Teresinha; Goldman, Katy Z.; Santos, João Paulo Fernandes; Pagani, Valeria; Simões, Ricardo Santos; Soares, José Maria; Simões, Manuel J.; Baracat, Edmund Chada

doi:10.1016/j.ejogrb.2006.05.024

Cited by 42 publications

(24 citation statements)

References 20 publications

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“…Hormone replacement therapy has been correlated with enhancement of collagen production, increase in skin thickness, surface lipids, hydration, vascularisation and increase of the hair follicle life cycle (Brincat, 2000;Callens et al, 1996;Fuchs et al, 2003;Patriarca et al, 2007;Sator et al, 2007;Sator et al, 2001) leading to an improvement of skin tone and appearance. Hormone replacement may only improve the skin quality in female patients treated during the first 24 months after menopause (Phillips et al, 2008) (Table I).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo an in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone /insulin like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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Section: Accepted M Manuscriptmentioning

confidence: 99%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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“…55 The study did not investigate the effects of either ET or topical estradiol alone. It is possible that ET triggers systemic responses that enable topical estradiol to promote collagen production in photoaged skin, or vice versa.…”

Section: Commentmentioning

confidence: 99%

Induction of Collagen by Estradiol

Rittié¹,

Kang²,

Voorhees³

et al. 2008

Arch Dermatol

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To evaluate the effectiveness of topical estradiol in stimulating collagen I and III production in naturally aged and photoaged human skin of postmenopausal women and age-matched men.Design: Vehicle-controlled treatment followed by biochemical and immunohistochemical analyses of skin biopsy specimens.Setting: Academic referral center.Participants: Seventy healthy volunteers (40 postmenopausal women with a mean age of 75 years, and 30 men with a mean age of 75 years) with photodamaged skin.Interventions: Topical application of estradiol, 0.01%, 0.1%, 1%, or 2.5% or vehicle on aged or photoaged skin, with biopsy specimens taken after last treatment.Main Outcome Measures: De novo synthesis of collagen by quantitative polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay.Results: Topical estradiol increased procollagen I and III messenger RNA and collagen I protein levels in sun-protected aged hip skin in postmenopausal women and, to a lesser extent, in age-matched men. Surprisingly, no significant changes in production were observed in women or men after 2-week estradiol treatment of photoaged forearm or face skin, despite similar expression of estrogen receptors (ER-␣, ER-␤, and GPR30) in aged and photoaged skin. Estradiol treatment induced the estrogenresponsive gene GREB1, indicating that penetration of topical estradiol and genomic response to estrogen were similar in the 3 anatomic sites.Conclusions: Two-week topical estradiol treatment stimulates collagen production in sun-protected hip skin, but not in photoaged forearm or face skin, in postmenopausal women and aged-matched men. These findings suggest that menopause-associated estrogen decline is involved in reduced collagen production in sun-protected skin. Interestingly, alterations induced by long-term sun exposure hinder the ability of topical 2-week estradiol to stimulate collagen production in aged skin.

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“…Soy isoflavones are known to have various biological effects through oestrogen receptor activity and are often used in cosmetic formulation for mature skin [34,35]. However, they contain estrogenic metabolites and possess phytohormonal activity, which is often not desired.…”

Section: Discussionmentioning

confidence: 99%

Pentacyclic Triterpenes from <b><i>Terminalia arjuna</i></b> Show Multiple Benefits on Aged and Dry Skin

Farwick

Köhler

Schild

et al. 2013

Skin Pharmacol Physiol

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Background: Pentacyclic triterpenoids improve epidermal barrier function and induce collagen production. Here, their effects on cutaneous aging by means of objective instrumental measurements were elucidated. Methods: Reconstituted human epidermis, cultivated keratinocytes and fibroblasts were incubated with Terminalia arjuna triterpenes (T. arjuna bark extract), and mRNA and protein expression of various genes was determined using microarray analysis, qRT-PCR and ELISA techniques. Clinical efficacy of T. arjuna bark extract versus vehicle control cream was elucidated in 30 patients and transepidermal water loss (TEWL), skin hydration and elasticity were measured. Another 30 female patients in their postmenopausal phase were treated with a similar regime, and skin sebum content, cutaneous blood microcirculation and skin density/echogenicity were assessed. Results: Incubation with T. arjuna triterpenes increased FGF-2, TSP-1, TGF-β and CTGF expression, and VEGF secretion in vitro. Elevated lactate dehydrogenase release upon sodium dodecyl sulphate challenge was reversed by the application of T. arjuna bark extract. T. arjuna bark extract decreased TEWL, improved skin moisturization, reduced scaliness and led to significantly improved skin elasticity. Also, increases in blood microflow and skin sebum content as well as improved skin thickness/echogenicity were noted on postmenopausal skin, resulting in visible reduction of sagging skin on the jowls as demonstrated by digital photography. Conclusion:T. arjuna bark extract appears as an innovative active ingredient that exerts versatile antiaging properties in vitro and in vivo.

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Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: A pilot study

Cited by 42 publications

References 20 publications

Skin and brain age together: The role of hormones in the ageing process

Skin and brain age together: The role of hormones in the ageing process

Induction of Collagen by Estradiol

Pentacyclic Triterpenes from <b><i>Terminalia arjuna</i></b> Show Multiple Benefits on Aged and Dry Skin

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