Effects of topical docosahexaenoic acid on postoperative fibrosis in an animal model of glaucoma filtration surgery

Carré, Chloé; Baudin, Florian; Buteau, Bénédicte; Martine, Lucy; Grégoire, Stéphane; Vasku, Glenda; Berdeaux, Olivier; Béduneau, Arnaud; Pellequer, Yann; Jamoussi, Jasmine; Desrumeaux, Catherine; Aho, Serge; Bron, A.; Acar, Niyazi; Creuzot‐Garcher, Catherine; Gabrielle, Pierre‐Henry

doi:10.1111/aos.15222

Cited by 1 publication

(2 citation statements)

References 33 publications

(39 reference statements)

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“…Topical docosahexaenoic acid showed inhibitory effects on bleb fibrosis to a degree that was comparable to mitomycin C in murine eyes following glaucoma filtration surgery [ 104 ]. Cellular oxidative stress is considered to be an underlying factor influencing the degeneration of trabecular meshwork endothelial cell degeneration and subsequent chronic IOP elevation [ 105 , 106 , 107 ].…”

Section: Resultsmentioning

confidence: 99%

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Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.

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Section: Resultsmentioning

confidence: 99%

“…The exclusion criteria 100 included: studies not published in English; duplicate studies; and, studies out of scope of 101 this work. 102 The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRIS-103 MA) [25] was used to populate this review in February 2023 using the PubMed database, 104 which is shown in Figure 1.…”

Section: Methodsmentioning

confidence: 99%