Effects of Topical Application of Ibudilast for Seasonal Allergic Conjunctivitis in Patients Wearing Soft Contact Lenses

Sakuma, Kazuhiko; Toshida, Hiroshi; Honda, Ryumon; Tanaka, Katsumi; Fukazawa, Ayumi; Takahashi, Kozo; Suto, Chikako; Ebihara, Nobuyuki; Murakami, Akira

doi:10.1097/icl.0b013e3181b4ec11

Cited by 2 publications

(2 citation statements)

References 8 publications

(7 reference statements)

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“…Many CL users with allergic conjunctivitis experience ocular allergic symptoms such as itching, hyperemia, and eye discharge while wearing CLs [ 9 , 10 ]. However, lens manufacturers do not recommend using eye drops while wearing CLs [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Use of Ketotifen Fumarate-Eluting Daily Disposable Soft Contact Lens in Management of Ocular Allergy: Literature Review and Report of Two Cases

Ono¹,

Toshida²

2022

Cureus

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We present two cases in which the drug-eluting daily disposable soft contact lens (DDSCL) Acuvue®Theravision TM with Ketotifen (Johnson & Johnson Vision Care, Inc., Jacksonville, Florida, USA) (ATK), which contains the anti-allergic drug ketotifen fumarate, alleviated ocular allergic symptoms. Case 1 was a 57-yearold woman with a history of allergic conjunctivitis in the spring and fall. In the summer and winter, the patient used frequent replacement soft contact lenses, but in the allergy seasons, she used DDSCLs in combination with anti-allergic eye drops. She agreed to start wearing ATK lenses from before the next fall season. The lenses suppressed her allergic signs and symptoms, and she felt comfortable wearing them and continued their use throughout the season. Her symptoms were suppressed, providing her comforts that enabled uses of the CLs for some time. She successfully used the lenses again from the beginning of the next spring season. Case 2 was a 31-year-old woman with a history of cedar pollinosis. The patient previously used DDSCLs and was prescribed ATK lenses at her regular clinic. About one month later, she was referred to our department. With ATK lenses, she did not experience any subjective symptoms during the pollinosis season. At a subsequent visit, hyperemia had decreased compared with the initial visit. In these two cases, the use of ATK lenses from before until the end of both the spring and fall allergy seasons suppressed the symptoms of allergic conjunctivitis, allowing the patients to continue to wear contact lenses.

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Section: Discussionmentioning

confidence: 99%

Use of Ketotifen Fumarate-Eluting Daily Disposable Soft Contact Lens in Management of Ocular Allergy: Literature Review and Report of Two Cases

Ono¹,

Toshida²

2022

Cureus

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“…Studies performed on SAC (seasonal allergic conjunctivitis) using ibudilast eye drops have shown a significant reduction in allergic symptoms and better outcomes compared with mastcell stabilizers (sodium cromoglycate) [88,89]. On the basis of these results, it would be interesting to test ibudilast eye drops on VKC, another form of allergic conjunctivitis characterized by an increase in TLR4 in the conjunctiva and associated with a decrease in TLR9.…”

Section: Ocular Surface Tlrs As Potential Targets Of Therapymentioning

confidence: 96%

Toll-like receptors in ocular surface diseases: overview and new findings

et al. 2011

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The ocular surface is the first line of defence in the eye against environmental microbes. The ocular innate immune system consists of a combination of anatomical, mechanical and immunological defence mechanisms. TLRs (Toll-like receptors), widely expressed by the ocular surface, are able to recognize microbial pathogens and to trigger the earliest immune response leading to inflammation. Increasing evidence highlights the crucial role of TLRs in regulating innate immune responses during ocular surface infective and non-infective inflammatory conditions. In addition, recent observations have shown that TLRs modulate the adaptive immune response, also playing an important role in ocular autoimmune and allergic diseases. One of the main goals of ocular surface treatment is to control the inflammatory reaction in order to preserve corneal integrity and transparency. Recent experimental evidence has shown that specific modulation of TLR pathways induces an improvement in several ocular inflammatory conditions, such as allergic conjunctivitis, suggesting new therapeutic anti-inflammatory strategies. The purpose of the present review is to summarize the current knowledge of TLRs at the ocular surface and to propose them as potential targets of therapy for ocular inflammatory conditions.

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Effects of Topical Application of Ibudilast for Seasonal Allergic Conjunctivitis in Patients Wearing Soft Contact Lenses

Abstract: These results suggest that topical application of ibudilast while using 2 Week Pure lenses can improve subjective symptoms without influencing drug adsorption or lens morphology.

Cited by 2 publications

References 8 publications

Use of Ketotifen Fumarate-Eluting Daily Disposable Soft Contact Lens in Management of Ocular Allergy: Literature Review and Report of Two Cases

Use of Ketotifen Fumarate-Eluting Daily Disposable Soft Contact Lens in Management of Ocular Allergy: Literature Review and Report of Two Cases

Toll-like receptors in ocular surface diseases: overview and new findings

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