Effects of Topical Antiglaucoma Application on Conjunctival Impression Cytology Specimens

Hong, Samin; Lee, Christopher Seungkyu; Seo, Kyoung Yul; Seong, Gong Je; Hong, Young Jae

doi:10.1016/j.ajo.2006.02.056

Cited by 48 publications

(22 citation statements)

References 5 publications

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“…Evidence from animal studies and human tissue cell culture experiments, which suggests that preservatives can cause detrimental effects on the superficial ocular tissues, is supported by evidence from clinical studies (Wilson et al 1975;Lemp & Zimmerman 1988;Sherwood et al 1989;Herreras et al 1992;Baudouin et al 1994;Broadway et al 1994a;de Jong et al 1994;Kuppens et al 1995;Yalvac¸et al 1995;Aritu¨rk et al 1996;Baudouin 1996;Baudouin & de Lunardo 1998;Nuzzi et al 1998;Levrat et al 1999;Albietz & Bruce 2001;Eleftheriadis et al 2002;Dogan et al 2004;Pisella et al 2004;Kozobolis et al 2005;Manni et al 2005;Hong et al 2006). The key studies are outlined here and a full list of references is provided in Table 1.…”

Section: Toxicity Of Preservatives: Evidence From Clinical Studiesmentioning

confidence: 75%

Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma

Baudouin

2008

Acta Ophthalmologica

231

146

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ABSTRACT.Antiglaucoma medications are often associated with ocular adverse reactions such as dry eye, and burning or stinging sensations. These undesirable effects may lead to treatment discontinuation and reduced quality of life in patients with glaucoma. Antiglaucoma medications usually contain benzalkonium chloride (BAK) as a preservative. Animal studies, in vitro studies and in vivo experiments have demonstrated various adverse effects of BAK. Clinical studies have also shown an increased incidence of adverse events with BAK and have demonstrated that the withdrawal of preservatives reduces these effects. Collectively, these data suggest that preservative-free antiglaucoma treatments have clinically relevant benefits for patients.

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Section: Toxicity Of Preservatives: Evidence From Clinical Studiesmentioning

confidence: 75%

Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma

Baudouin

2008

Acta Ophthalmologica

231

146

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“…Fixed-combination eye drop administered once daily had a similar effect on the ocular surface as the one-component antiglaucoma drug administration once daily after 6 weeks. Hong et al [15] reported that cytology scores were significantly lower in the monotherapy group than in the fixed-combination therapy group after at least 6 months (mean 11.67 ± 3.93 months) follow-up in human eyes. It seems that it takes[6 weeks to induce significant squamous metaplasia by once-daily antiglaucoma drugs whether it is a one-component or a fixed-combination drug.…”

Section: Discussionmentioning

confidence: 97%

Effects of antiglaucoma drugs on the ocular surface in rabbits: a fixed-combination drug versus two concomitant drugs

2011

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“…На фоне продолжительных инстилляций гипотензивных капель J. Brandt (1991) обнаружил метаплазию конъюнктивы, выраженность которой зависела от количества используемых препаратов [18]. По данным S. Hong (2006), местная терапия так-же обусловливает увеличение численности кле-ток, подвергшихся метаплазии [27].…”

Section: The Influence Of Local Iop-lowering Therapy On the Anterior unclassified

The influence of local IOP-lowering therapy on the anterior segment tissues and outcome of glaucoma filtering surgery

Petrov

Юрьевич²,

Lovpache

et al. 2017

Ophthalmology Reports

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Nowadays, a wide choice of local IOP-lowering medications allows ensuring a successful intraocular pressure compensation and primary open angle glaucoma stabilization. However, taking into consideration a long term action of drugs on the ocular surface, even without clinical manifestations there is a direct inflammatory cells’ activation with mixed toxic and allergic changes, which is confirmed by histology, immune-histology, and impression cytology methods. Such chronic sub-clinical inflammation represent a potential risk of excessive fibroblast proliferation with subsequent rapid postoperative scarring of new outflow pathways and atypical filtration bleb formation. It is shown that there is a clear relationship between number of glaucoma drugs used, treatment duration, intensity of conjunctival infiltration with inflammatory cells and fibroblasts, and risk of episcleral fibrosis and subconjunctival scarring during post-op period. (For citation: Petrov SYu, Lovpache DzhN, Loskutov IA, Safronova DM. The influence of local IOP-lowering therapy on the anterior segment tissues and outcome of glaucoma filtering surgery. Ophthalmology Journal. 2017;10(4):41-47. doi: 10.17816/OV10441-47).

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Effects of Topical Antiglaucoma Application on Conjunctival Impression Cytology Specimens

Cited by 48 publications

References 5 publications

Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma

Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma

Effects of antiglaucoma drugs on the ocular surface in rabbits: a fixed-combination drug versus two concomitant drugs

The influence of local IOP-lowering therapy on the anterior segment tissues and outcome of glaucoma filtering surgery

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