Effects of topical and subconjunctival use of bevacizumab on corneal
            neovascularization in rabbits’ eyes

Lopes, Gerson Jorge Aparecido; Casella, Antônio Marcelo Barbante; Oguido, Ana Paula Miyagusko Taba; Matsuo, Tiemi

doi:10.5935/0004-2749.20170061

Cited by 7 publications

(2 citation statements)

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“…A recent doublemasked, randomized trial also illustrated significant improvement in tear-film stability, corneal staining, and symptoms in DED patients treated with bevacizumab eye drops [50]. Bevacizumab has also been recently used in meibomian gland dysfunction-associated posterior blepharitis [51], demonstrating that intra-meibomian gland injection and eye drops can significantly improve DED symptoms. Ongoing studies regarding bevacizumab on experimental CNV models have illustrated a reduction in CNV area and the number of blood vessels [52][53][54], making these existing anti-VEGF therapies a viable option for the expansion of use in external eye disease.…”

Section: Anti-vegf Therapies In External Eye Diseasesmentioning

confidence: 98%

A Systematic Review of Tear Vascular Endothelial Growth Factor and External Eye Diseases

Chan,

Lim,

Lee

et al. 2024

IJMS

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We aim to summarize the current evidence of Vascular endothelial growth factors (VEGF)s in external eye diseases and determine whether serum and plasma VEGF levels are associated with tear and ocular surface tissues. A systematic search of PUBMED and EMBASE was conducted using PRISMA guidelines between October 2022 and November 2023, with no restriction on language or publication date. Search terms included relevant MESH terms. These studies were evaluated for quality, and an assessment of the risk of bias was also carried out. Extracted data were then visually represented through relevant tables or figures. The initial literature search yielded 777 studies from PUBMED, 944 studies from EMBASE, and 10 studies from manual searches. Fourteen eligible studies were identified from 289 articles published from 2000 to 2023 in the English language or with English translations, including rabbit models, murine models, and human-derived samples. Most studies were retrospective in nature and case–control studies. Various common external eye diseases, such as dry eye disease (DED) and allergic eye disease were investigated. Despite limitations and small sample sizes, researchers have found elevated tissue levels of the VEGF in the vascularized cornea, especially in animal models, but there is no evidence of clear changes in the tear concentrations of VEGF in DED and allergic eye disease. Tear VEGF is associated with corneal vascularization. Anti-VEGF therapies may have the potential to manage such conditions.

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Section: Anti-vegf Therapies In External Eye Diseasesmentioning

confidence: 98%

A Systematic Review of Tear Vascular Endothelial Growth Factor and External Eye Diseases

Chan,

Lim,

Lee

et al. 2024

IJMS

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“…Several animal models of alkali burn have been used to evaluate the corneal wound healing process (Choi et al, 2017) and to test drugs that reduce the scarring or corneal opacity (Griffith GL et al, 2018;Haddox et al, 2001;Lopes et al, 2017;Zahir-Jouzdani F, 2018). All of the procedures use sodium hydroxide to produce the alkali burn.…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes of the extracellular matrix during corneal wound healing

Lorenzo-Martín

Gallego‐Muñoz

Mar

et al. 2019

Experimental Eye Research

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The extracellular matrix (ECM) confers transparency to the cornea because of the precise organization of collagen fibrils and a wide variety of proteoglycans. We monitored the corneal wound healing process after alkali burns in rabbits. We analyzed the location and expression of collagens and proteoglycans, the clinical impact, and the recovery of optical transparency. After the animals received both general and ocular topical anesthesia, the central cornea of the left eye was burned by placing an 8-mm diameter filter paper soaked in 0.5 N NaOH for 60 s. The eyes were evaluated under a surgical microscope at 1, 3, and 6 months after burning. At each time point, the clinical conditions of the burned and control corneas were observed. The arrangement of collagen fibers in the corneal stroma was visualized by Picrosirius-red staining, Gomori's silver impregnation and transmission electronic microscopy. Corneal light transmittance was also measured. Myofibroblasts presence was analyzed by immunohistochemistry. mRNA expression levels of collagen types I and III, lumican, decorin, keratocan and alpha-smooth muscle actin were determined by quantitative real-time polymerase chain reaction. One month after alkali burn, the ECM was disorganized and filled with lacunae containing different types of cells and collagen type III fibers in the wound area. Corneal opacities were present with attendant loss of light transmittance. Collagen and proteoglycan mRNA expression levels were up-regulated. After three months, wound healing progress was indicated by reduced corneal opacity, increased light transmittance, reorganization of collagen fibers and only collagen type I expression levels were at control levels. After six months, the wound area ECM morphology was similar to controls, but transmittance values remained low, denoting incomplete restoration of the stromal architecture. This multidisciplinary study of the stromal wound healing process revealed changes in corneal transmittance, collagen organization, myofibroblasts presence and ECM composition at 1, 3, and 6 months after alkali burning. Documenting wound resolution during the six-month period provided reliable information that can be used to test new therapies.

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Effect of adalimumab on experimental corneal neovascularization model

et al. 2023

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Effects of topical and subconjunctival use of bevacizumab on corneal neovascularization in rabbits’ eyes

Abstract: Bevacizumab showed an inhibitory effect on CNV in rabbits' eyes after chemical burning of the cornea. There was no difference between the topical or subconjunctival administration of bevacizumab in the inhibition of CNV.

Cited by 7 publications

References 0 publications

A Systematic Review of Tear Vascular Endothelial Growth Factor and External Eye Diseases

A Systematic Review of Tear Vascular Endothelial Growth Factor and External Eye Diseases

Dynamic changes of the extracellular matrix during corneal wound healing

Effect of adalimumab on experimental corneal neovascularization model

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