Effects of Topical and Oral Vitamin E on Pigmentation and Skin Cancer Induced by Ultraviolet Irradiation in Skh:2 Hairless Mice

Burke, Karen E.; Clive, Jonathan; Combs, Gerald F.; Commisso, Joel; Keen, Carl L.; Nakamura, Robert M.

doi:10.1207/s15327914nc381_13

Cited by 97 publications

(74 citation statements)

References 34 publications

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“…Topical preparations containing selenium sulfide are frequently used to manage tinea versicolor, seborrheic dermatitis, and dandruff [41,42] . It is commonly incorporated into shampoo for treating dandruff.…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species

Lin

Fang²,

Al‐Suwayeh

et al. 2011

Acta Pharmacol Sin

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Aim: To investigate the in vitro and in vivo percutaneous absorption of seleno-L-methionine (Se-L-M), an ultraviolet (UV)-protecting agent, from aqueous solutions. Methods: Aqueous solutions of Se-L-M were prepared in pH 4, 8, and 10.8 buffers. The pH 8 buffer contained 30% glycerol, propylene glycol (PG) and polyethylene glycol (PEG) 400. The in vitro skin permeation of Se-L-M via porcine skin and nude mouse skin was measured and compared using Franz diffusion cells. The in vivo skin tolerance study was performed, which examined transepidermal water loss (TEWL), skin pH and erythema. Results: In the excised porcine skin, the flux was 0.1, 11.4 and 8.2 μg· cm -2 ·h -1 for the pH 4, 8, and 10.8 buffers, respectively. A linear correlation between the flux and skin deposition was determined. According to permeation across skin with different treatments (stripping, delipidation, and ethanol treatments), it was determined that the intracellular route comprised the predominant pathway for Se-L-M permeation from pH 8 buffer. Aqueous solutions of seleno-DL-methionine (Se-DL-M), selenium sulfide and selenium-containing quantum dot nanoparticles were also used as donor systems. The DL form showed a lower flux (7.0 vs 11.4 μg· cm -2 ·h -1 ) and skin uptake (23.4 vs 47.3 μg/g) as compared to the L form, indicating stereoselective permeation of this compound. There was no or only negligible permeation of selenium sulfide and quantum dots into and across the skin. With in vivo topical application for 4 and 8 h, the skin deposition of Se-L-M was about 7 μg/g, and values were comparable to each other. The topical application of Se-L-M for up to 5 d did not caused apparent skin irritation. However, slight inflammation of the dermis was noted according to the histopathological examination. Conclusion: Se-L-M was readily absorbed by the skin in both the in vitro and in vivo experiments. The established profiles of Se-L-M skin absorption will be helpful in developing topical products of this compound.Keywords: seleno-L-methionine; selenium; percutaneous absorption; topical delivery; skin [5] . In humans, a low selenium status is associated with up to a 4-fold increased risk of developing skin cancer [6] . Topical selenium compounds also increase the minimum dose of UV radiation required to cause skin reddening and protect against skin damage caused by UVB [7,8] . Seleno-L-methionine (Se-L-M), the major component of dietary selenium, represents an organic form of selenium which may provide enhanced protection of the skin [9] . Se-L-M also decreases the oxidative stress of neurodegenerative diseases, rheumatoid arthritis, and HIV/AIDS [10,11] . Most ingested selenium, whether in organic or inorganic form, is converted by liver metabolism [3] . In addition, selenium toxicity can produce gastrointestinal problems [12] . Delivery of pharmacologically active compounds via the skin is an attractive alternative to oral dosing for numerous reasons including stable plasma concentrations, bypass of firstpass effects, and reduction of some si...

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Section: Discussionmentioning

confidence: 99%

In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species

Lin

Fang²,

Al‐Suwayeh

et al. 2011

Acta Pharmacol Sin

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“…There are many reports of ␣ -tocopherol protecting the skin against damage produced by oxidative stresses from UVB ( 24 , 25 ), ␣ -tocopherol levels in the skin decreasing after UV irradiation ( 6 ) or topical application of vitamin E being more useful in comparison with oral ingestion ( 26 ). On the other hand, a review by Sies and Stahl ( 27 ) showed that while nutritional protection against skin damage from sunlight is provided by carotenoids, tocopherols, ascorbate, flavonids, or n -3 fatty acids, the effects of tocopherols in human dietary photoprotection were slight.…”

Section: Discussionmentioning

confidence: 99%

Dietary Tocotrienol Reduces UVB-induced Skin Damage and Sesamin Enhances Tocotrienol Effects in Hairless Mice

Yumura

Obayashi

Ishikawa

et al. 2008

J Nutr Sci Vitaminol

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SummaryWe have previously reported that substantial amounts of tocotrienols were present in the skin of animals fed a diet containing a tocopherols and tocotrienols rich fraction (T-mix) extracted from palm oil, and further, that sesame lignans enhanced tocotrienol levels in the skin. The present studies were undertaken to determine whether dietary tocotrienols and those with sesamin could protect the skin from damage induced by UVB irradiation in hairless mice fed four diets: a vitamin E-free diet, a 50 mg/kg ␣ -tocopherol diet, a 229 mg/kg T-mix (with 50 mg ␣ -tocopherol) diet and a 229 mg/kg T-mix with 2 g/kg sesamin diet. In Experiment 1, mice were fed the diets for 6 wk, and half of the mice were exposed to 180 mJ/cm 2 of UVB light once daily for 7 d. After the intensity of sunburn was scored, vitamin E and thiobarbituric acid reactive substances (TBARS) concentrations in the skin and liver were determined. In Experiment 2, hairless mice were initiated with a single application of 7, 12-dimethylbenz[a]anthracene (DMBA), then 1 wk later mice were fed the experimental diets and subjected to 180 mJ/cm 2 UVB irradiation twice weekly for 20 wk. Tumor incidences were counted once a week. Tocotrienols were detected in the skin of mice fed T-mix, but their concentrations were significantly lower than for ␣ -tocopherol. Sesamin elevated tocotrienol contents in the skin. In spite of the high ␣ -tocopherol contents, the effects of ␣ -tocopherol on sunburn and incidence of tumor were slight. T-mix fed groups reduced the extent of sunburn and incidence of tumor, and further reduction of sunburn and incidence of tumor were observed in the T-mix with sesamin group. These results suggest that dietary tocotrienols protect the skin more strongly than ␣ -tocopherol against damage induced by UVB and sesamin enhances tocotrienol effects.

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“…It is also effective in some skin conditions resulting from both acute and chronic UV exposure, such as wrinkles [ 24 ] and skin cancers [ 25 ] . Topical combination with vitamin C enhances its antioxidant and photoprotective effects, as well as its stability [ 3 ] .…”

Section: E Vitaminsmentioning

confidence: 99%

Cosmeceuticals in Dermatology

Tedeschi

West

Guzzardi

et al. 2013

Update in Cosmetic Dermatology

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Effects of Topical and Oral Vitamin E on Pigmentation and Skin Cancer Induced by Ultraviolet Irradiation in Skh:2 Hairless Mice

Cited by 97 publications

References 34 publications

In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species

In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species

Dietary Tocotrienol Reduces UVB-induced Skin Damage and Sesamin Enhances Tocotrienol Effects in Hairless Mice

Cosmeceuticals in Dermatology

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