Effects of Tomato and Soy on Serum Adipokine Concentrations in Postmenopausal Women at Increased Breast Cancer Risk: A Cross-Over Dietary Intervention Trial

Llanos, Adana A.M.; Peng, Juan; Pennell, Michael L.; Krok, Jessica L.; Vitolins, Mara Z.; DeGraffinreid, Cecilia R.; Paskett, Electra D.

doi:10.1210/jc.2013-3222

Cited by 14 publications

(29 citation statements)

References 34 publications

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“… 57 Furthermore, studying the protein expression of several inflammatory markers in situ has the advantage of indicating local mechanisms by which the antioxidant is more likely to act on in the breast tissue. Unlike previous studies that have measured these markers in the blood, 17 - 22 our assessments may better reflect the local breast microenvironment since measures are directly obtained from the breast source. However, with these types of analyses, the risk of statistical multiplicity increases, which increases the likelihood of rare events.…”

Section: Discussionmentioning

confidence: 99%

“…Among the few studies that examined the association between antioxidant intakes and circulating levels of inflammatory markers (3 observational 17 - 19 and 3 experimental 20 - 22 ), intakes of retinol, carotenoids, lycopene, vitamin C or E tended to be negatively associated with C-reactive protein (CRP), 17 , 18 , 20 interleukin (IL)-1β, 19 or leptin 21 and positively associated with adiponectin. 21 However, since inflammatory marker concentrations were obtained from blood analysis, these may not adequately reflect levels found in the tumor microenvironment (breast tissue). Indeed, studies have shown that circulating levels of inflammatory markers such as leptin, adiponectin, and transforming growth factor (TGF)-β differ from concentrations measured in mammary tissue.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients

et al. 2016

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Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer. Antioxidant intakes were collected using a self-administered food frequency questionnaire. Inflammation marker expression was assessed by immunohistochemistry. Correlations between antioxidant intakes and inflammatory marker expression were evaluated using Spearman’s partial correlation coefficients (r) for all women and for premenopausal and postmenopausal women separately. After Bonferroni correction, negative correlations were observed between dietary β-tocopherol and IL-10 expression in all women combined (r = −0.26, P = .003) and among postmenopausal women (r = −0.39, P = .003). For all women, a negative correlation was found between total zinc intakes and IL-10 (r = −0.26, P = .002). Among postmenopausal women, dietary selenium intake was negatively correlated with the expression of lactoferrin (r = −0.39, P = .003). No associations were observed in premenopausal women. Our findings suggest that consumption of specific antioxidants, including β-tocopherol, zinc, and selenium, may act on the breast tissue through mechanisms affecting the expression of some inflammation markers, particularly among postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients

et al. 2016

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“…Our data provides additional evidence for a biological link between menopausal status, hereditary factor, BMI and breast cancer, suggesting an independent role of different circulating adiponectin in the carcinogenesis of breast cancer. In addition, because circulating adiponectin can be influenced by a number of behavioral and drug interventions, such as fruit, weight loss, the observation in this study may help guide a preventive strategy for breast cancer[ 29 – 31 ]. Further investigation into the association between HMW adiponectin, HMW/total adiponectin ratio, the participation of the different receptors, and ADIPOQ polymorphisms are necessary.…”

Section: Discussionmentioning

confidence: 99%

Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study

et al. 2015

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The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed.

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“…По данным других исследователей, каждые 10 г ПВ в питании достоверно на 7 % снижали риск развития РМЖ [29]. Исследования американских эндокринологов [30] показали достоверное повышение концентрации адипонектина на фоне дополнительного обогащения рациона питания продуктами, содержащими томат (более 25 мг ликопина), в группе женщин с повышенным риском РМЖ. Чем больше употребление адипонектина, тем меньше риск РМЖ, особенно у женщин в постменопаузе.…”

Section: результаты и обсуждениеunclassified

Vegetables and fruits in the prevention and treatment of cancer in the light of evidence-based medicine (part 1)

Zakrevskii¹,

Liflyandsky²

2017

Vestnik SPbSU. Medicine

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1 Северо-Западный государственный медицинский университет им. И. И. Мечникова, Российская Федерация, 191015, Санкт-Петербург, ул. Кирочная, 41 10.21638/11701/spbu11.2017.409 Проанализировано влияние овощей и плодов на риск развития различных типов онкологических заболеваний и обоснована возможность их использования в профилактике рака и повышении качества жизни больных раком. Наиболее выраженные профилактические свойства установлены у яблок и цитрусовых, темных сортов винограда, черники, черной смородины, малины (особенно ежевикообразной), овощей, содержащих каротиноиды (томаты, морковь, тыква и др.), а также луковых, крестоцветных и листовых овощей. Как одни из наиболее эффективных противораковых компонентов проявили себя пищевые волокна в составе продуктов питания. Пищевые волокна в составе биологически активных добавок противоракового действия не оказывали, а иногда повышали риск развития некоторых онкологических заболеваний. Противораковое действие также установлено для многих фитонутриентов, входящих в состав различных овощей и плодов, -антиоксидантов, каротиноидов, фолатов, флавоноидов, изотиоцианатов, ресвератрола, аллицина и диалилсульфида, но не для биологически активных добавок, содержащих указанные соединения. Доказана опасность избыточного потребления таких нутриентов, как селен, альфа-токоферол и омега-3 жирные кислоты, которые, в частности, повышали риск развития рака предстательной железы, каротиноидырака легких, а комплексные биологически активные добавки с антиоксидантами -рака мочевого пузыря. Овощи, консервированные солением и маринованием, а также жареные повышают риск развития рака, в основном органов пищеварения. Бесконтрольное применение БАД с селеном, альфа-токоферолом, омега-3 жирными кислотами, каротиноидами и другими нутриентами способно провоцировать ракообразование. Библиогр. 51 назв.Ключевые слова: овощи, фрукты, ягоды, профилактика и лечение рака, доказательная медицина.Surveys of existing literature analyzed the effect of vegetables and fruits on the risk of developing various types of cancer and justified the possibility of their use for the prevention of the risk of cancer and the improvement of the quality of life in patients with cancer. Apples and citrus have the Вестник СПбГУ. Медицина. 2017. Т. 12. Вып. 4 most pronounced prophylactic properties along with dark grapes, blueberries, black currants, and blackberries, vegetables containing carotenoids (tomatoes, carrots, pumpkin, etc.), as well as onion, cruciferous and leafy vegetables. Dietary fiber is one of the most effective anti-cancer components in food composition. The anticancer effects of dietary fiber in dietary supplements has not been not provided, and sometimes resulted in the increase of risk of certain cancers. Also installed the anti-cancer effect for many of the phytonutrients included in the composition of different vegetables and fruitsantioxidants, carotenoids, folate, flavonoids, isothiocyanates, resveratrol, allicin and diallylsulfide, but not for biologically active additives (dietary supplements) ...

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Effects of Tomato and Soy on Serum Adipokine Concentrations in Postmenopausal Women at Increased Breast Cancer Risk: A Cross-Over Dietary Intervention Trial

Cited by 14 publications

References 34 publications

Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients

Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients

Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study

Vegetables and fruits in the prevention and treatment of cancer in the light of evidence-based medicine (part 1)

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