Abstract:Despite intensive study the locus of action of tolbutamide on.carbohydrate metabolism in man is unknown. Evidence obtained by direct infusions into the pancreas in animals strongly suggests that the drug stimulates the secretion or release of insulin by the fl cells. On the other hand, there is equally strong evidence to indicate that some metabolic effects of tolbutamide are different from those observed following subcutaneous or intravenous injection of insulin. The present report describes differences in fr… Show more
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