Effects of Toceranib Phosphate on Systolic Blood Pressure and Proteinuria in Dogs

Tjostheim, Sonja S.; Stepien, Rebecca L.; Markovic, Lauren E.; Stein, Timothy J.

doi:10.1111/jvim.13951

Cited by 23 publications

(18 citation statements)

References 42 publications

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“…In addition, the toxicities observed, such as diarrhea, decreased appetite, lameness/muscle weakness, proteinuria, and hypertension, were those previously associated with toceranib [30, 32]. Neutropenia was not reported in this group of dogs.…”

Section: Discussionsupporting

confidence: 50%

Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of inoperable, metastatic, or recurrent canine pheochromocytomas: 5 dogs (2014–2017)

et al. 2018

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BackgroundEffective treatment options for inoperable, metastatic, or recurrent canine pheochromocytomas are lacking. In humans, specific germline mutations exist that drive the development of pheochromocytomas. Pharmaceutical blockade of these abnormalities with small molecule inhibitors are an effective treatment strategy. Similar mutations may exist in the dog, and thus, treatment with similar small molecule inhibitors may provide a survival advantage. The purpose of this study was to assess the role of toceranib phosphate in the treatment of inoperable, metastatic, or recurrent canine pheochromocytomas.ResultsRetrospectively, medical records of dogs that had a diagnosis or suspect diagnosis of a pheochromocytoma were reviewed for information regarding response to toceranib phosphate and overall outcome. Five dogs were identified that fit the inclusion criteria. All five experienced clinical benefit (1 partial response, 4 stable disease). Progression-free interval (PFI) for the dog with the partial response was 61 weeks. PFI for the two dogs with stable measurable disease were 36 weeks and 28 weeks. PFI in the two dogs with stable metastatic disease were at least 11 weeks and 18 weeks.ConclusionsBased on this limited series of dogs, the results suggest that toceranib may have biological activity in dogs with primary and metastatic pheochromocytomas. Larger studies are needed to define the use and response to toceranib in dogs with gross, microscopic, and metastatic pheochromocytoma.

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Section: Discussionsupporting

confidence: 50%

Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of inoperable, metastatic, or recurrent canine pheochromocytomas: 5 dogs (2014–2017)

et al. 2018

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“…The TKIs generally are well tolerated, but have been associated with several adverse effects. Similar toxicities have been observed in both people and dogs, including gastrointestinal toxicity, muscle or joint pain, hypertension, and neutropenia …”

supporting

confidence: 62%

Effects of Toceranib Phosphate on the Hypothalamic‐Pituitary‐Thyroid Axis in Tumor‐Bearing Dogs

Hume

Rizzo

Balkman

2017

Veterinary Internal Medicne

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BackgroundThyroid dysfunction is associated with the use of tyrosine kinase inhibitors (TKI) in people.Hypothesis/ObjectivesTo determine whether dysfunction in the hypothalamic‐pituitary‐thyroid axis occurs in dogs receiving the TKI, toceranib phosphate.AnimalsForty‐three client‐owned dogs with cancer.MethodsProspective, observational study. Concentrations of total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), and thyroid‐stimulating hormone (TSH) were evaluated on day 0, 30, and 90. Dogs also were evaluated for the presence of thyroglobulin autoantibodies.ResultsThe proportion of dogs with low TT4, low FT4, low TT3, high TSH, or primary hypothyroidism (increased TSH and decreased TT4, FT4 or both) did not change over 90 days. Hormone concentrations remained within laboratory reference intervals, but FT4 (P = 0.0032) and TSH (P < 0.0001) changed over time. Mean FT4 was 1.22 ng/dL (95% confidence interval [CI], 1.10–1.34) on day 0 and 1.00 ng/dL (95% CI, 0.86–1.16) on day 90. Mean TSH was 0.17 ng/mL (95% CI, 0.13–0.23) on day 0 and 0.34 ng/mL (95% CI, 0.24–0.48) on day 90. Furthermore, TT4/TT3 ratio also changed over time (P = 0.0086). Mean TT4/TT3 ratio was 2.57 (95% CI, 2.26–2.88) on day 0 and 2.02 on day 90 (95% CI, 1.61–2.44). Thyroglobulin autoantibodies were not detected in any dog.Conclusions and Clinical ImportanceToceranib phosphate can disrupt the hypothalamic‐pituitary‐thyroid axis in dogs. Periodic evaluation of TT4, FT4, TT3, and TSH should be carried out in dogs receiving long‐term treatment with this medication.

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“…, Tjostheim et al . ). While none of the dogs in this study had previously received toceranib, eight were on prednisone at the time of their initial proteinuria screening.…”

Section: Discussionmentioning

confidence: 97%

Prevalence of proteinuria in a canine oncology population

Prudic

Saba

Lourenço

et al. 2018

J of Small Animal Practice

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Effects of Toceranib Phosphate on Systolic Blood Pressure and Proteinuria in Dogs

Cited by 23 publications

References 42 publications

Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of inoperable, metastatic, or recurrent canine pheochromocytomas: 5 dogs (2014–2017)

Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of inoperable, metastatic, or recurrent canine pheochromocytomas: 5 dogs (2014–2017)

Effects of Toceranib Phosphate on the Hypothalamic‐Pituitary‐Thyroid Axis in Tumor‐Bearing Dogs

Prevalence of proteinuria in a canine oncology population

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