Effects of titrated arginine vasopressin on hemodynamic variables and oxygen transport in healthy and endotoxemic sheep

Abstract

During ovine endotoxemia, AVP decreased cardiac index, compromised oxygen delivery, and increased pulmonary vascular resistance index. These side effects may limit its use as a sole vasopressor during sepsis. Potentially, a simultaneous infusion of AVP and NE could represent a useful therapeutic option.

Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemia

“…After approval by the German Government Animal Research Committee, 27 female adult sheep weighing 40 ± 2 kg were operatively instrumented for chronic study using an established protocol [12][13][14]. In brief, anesthesia was induced with intramuscular ketamine (20-25 mg/kg Ketanest 25; Parke-Davis Berlin, Freiburg, Germany) and supplemented with a continuous infusion of propofol (4-7 mg/kg/h Disoprivan, AstraZeneca, Schwetzingen, Germany) to avoid gross movements, but without compromising spontaneous breathing.…”

“…The aim of the current study was, therefore, to directly compare the effects of TP bolus versus continuous infusion on organ functions using an established large animal model of endotoxemic shock [12][13][14].…”

Effects of terlipressin on pulmonary artery pressure in a septic cooled infant: an echocardiographic assessment

“…9 Both AVP and TP have been proven effective in treating sepsis-related hypotension and reducing catecholamine requirements in the experimental 10,11 and clinical 12,13 settings. While TP may hold theoretical and anecdotal advantages over AVP, this has not been formally tested in prospective randomized trials, and its use remains controversial.…”

Traitement de la défaillance cardiaque

“…Les eff ets indésirables de l'AVP sont dus à sa propension à aggraver les phéno-mènes d'hypoperfusion périphérique, notamment splanchnique, rénale et cutanée, par vasoconstriction et diminution du transport en oxygène (41). Dans l'étude VASST, il n'y avait toutefois pas de diff érence signifi cative en terme d'évènements indésirables graves tous confondus, entre les deux stratégies de soutien hémodynamique.…”