Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae

Miao, Wei; Zhu, Biran; Xiao, Xiaohong; Liu, Ying; Dirbaba, Niguse Bekele; Zhou, Bingsheng; Wu, Hongjuan

doi:10.1016/j.aquatox.2015.02.002

Cited by 102 publications

(48 citation statements)

References 70 publications

(82 reference statements)

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“…Other previous study reported that chronic exposure to sub lethal dose of silver nanoparticles disrupts thyroid hormone signaling, which may explain the result of this study concerning thyroid function after long term exposure (30) day, to high dose of AgNps (50 mg/Kg) [24]. Meanwhile, others suggested that the reduction of T 4 due to the endocrine disruptor metals was attributed to the alteration in the expression of thyroid hormone synthesis gene in hypothalamic-pituitarythyroid axis [25]. In general, most of the thyroid disruptor chemicals affect the thyroid status by interfering with the different steps involved in thyroid hormone production such as iodine trapping process, cellular uptake, and interconversion between thyroid hormones, disposition, and elimination of the hormone [26].…”

Section: Discussionsupporting

confidence: 57%

Effects of Silver Nanoparticles on Thyroid Gland Structure and Function in Female Rats

Sulaiman

Luaibi

Qassim³

2018

Asian J Pharm Clin Res

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Objective: Due to their unique properties, silver nanoparticles (AgNPs) gained a broad utilization in nano-based industries and medicine, which may expose human to increased levels of NPs. However, little is known about their potential harmful effects on endocrine physiology. Hence, this study aimed to investigate the potential dose- and time-dependent outcomes of AgNPs on serum levels of thyroid hormones and thyroid gland histology in female rats.Methods: A total of 60 female rats were divided into three groups (each of 20 animals), treated with AgNPs for (10, 20, and 30) days. Within each treatment period, animals were assigned into four subgroups each of five rats; control treated with vehicle and the others treated with 12.5, 25, and 50 mg/kg of AgNPs, respectively, by intraperitoneal injection. At the end of treatments, all rats were sacrificed; blood samples were obtained and analyzed for serum levels of T3, T4, and thyroid-stimulating hormone (TSH). Thyroid gland was removed and weighed then kept in buffered formalin solution for microscopic examination.Results: The data showed a significant increase in the weight of the thyroid gland after 20 and 30 days of the treatment with 50 mg/kg of AgNPs, while the 25 mg/kg dose of AgNps resulted in significant increase only after 30 days. Serum levels of T3 and TSH were nonsignificantly altered by AgNPs in all the treatment groups. Thyroxin levels (T4) were significantly decreased after long-term exposure. Histological specimens of AgNPs treated group showed disturbance of the normal architecture of the thyroid tissue with degeneration of thyroid follicles and desquamated luminal cells.Conclusion: The results of the current study suggested the possible disrupting potential of long-term exposure to high level of AgNPs on thyroid gland function and histology in female rats.

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Section: Discussionsupporting

confidence: 57%

Effects of Silver Nanoparticles on Thyroid Gland Structure and Function in Female Rats

Sulaiman

Luaibi

Qassim³

2018

Asian J Pharm Clin Res

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“…The results also showed that there is no effect on the expression of the ERα gene. Another experiment by Miao et al [66] reported that the titanium dioxide nanoparticles increased the bioconcentration of lead, and directs the interruption of thyroid endocrine system in larvae of zebrafish.…”

Section: Different Assessment Methods To Evaluate Nanoparticle Toxicitymentioning

confidence: 99%

Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

et al. 2016

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Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range of industries, such as medicine, electronics and chemistry. In the current era, the commercial transition of nanotechnology from research level to industrial level is stimulating the world’s total economic growth. However, commercialization of nanoparticles might offer possible risks once they are liberated in the environment. In recent years, the use of zebrafish (Danio rerio) as an established animal model system for nanoparticle toxicity assay is growing exponentially. In the current in-depth review, we discuss the recent research approaches employing adult zebrafish and their embryos for nanoparticle toxicity assessment. Different types of parameters are being discussed here which are used to evaluate nanoparticle toxicity such as hatching achievement rate, developmental malformation of organs, damage in gill and skin, abnormal behavior (movement impairment), immunotoxicity, genotoxicity or gene expression, neurotoxicity, endocrine system disruption, reproduction toxicity and finally mortality. Furthermore, we have also highlighted the toxic effect of different nanoparticles such as silver nanoparticle, gold nanoparticle, and metal oxide nanoparticles (TiO2, Al2O3, CuO, NiO and ZnO). At the end, future directions of zebrafish model and relevant assays to study nanoparticle toxicity have also been argued.

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“…This process enhances the permeability of membranes by pore formation, providing the route of entry for foreign materials (Sincai et al, ). TiO 2 NPs promoted the accumulation of Pb in zebrafish embryos, this indicates the increased threat of heavy metal accumulation diseases in animals and humans in the presence of NPs (Miao et al, ). The accumulation of released Co 2+ and Fe 3+ from CoFe 2 O 4 NPs also contributed in promoting the intracellular membrane damage and ROS production by Fenton reaction (Ahmad et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…(C)] also confirmed the elevated mutations in the DNA as well. Silver (Ag) and titanium dioxide (TiO 2 ) NPs were reported to cause the up regulation of TH‐ disrupting gene ( tg ) in bullfrogs ( Rana catesbeiana ) and in developing zebrafish embryos (Carew et al, ; Miao et al, ). These genetic alterations may then be transfer to the next generation cause infant abnormality and increase death rate, posing serious threat to the environment and human community.…”

Section: Discussionmentioning

confidence: 99%

Assessment of thyroid endocrine system impairment and oxidative stress mediated by cobalt ferrite (CoFe₂O₄) nanoparticles in zebrafish larvae

et al. 2015

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Fascinating super paramagnetic uniqueness of iron oxide particles at nano-scale level make them extremely useful in the state of the art therapies, equipments, and techniques. Cobalt ferrite (CoFe O ) magnetic nanoparticles (MNPs) are extensively used in nano-based medicine and electronics, results in extensive discharge and accumulation into the environment. However, very limited information is available for their endocrine disrupting potential in aquatic organisms. In this study, the thyroid endocrine disrupting ability of CoFe O NPs in Zebrafish larvae for 168-h post fertilization (hpf) was evaluated. The results showed the elevated amounts of T4 and T3 hormones by malformation of hypothalamus pituitary axis in zebrafish larvae. These elevated levels of whole body THs leads to delayed hatching, head and eye malformation, arrested development, and alterations in metabolism. The influence of THs disruption on ROS production and change in activities of catalase (CAT), mu-glutathione s-transferase (mu-GST), and acid phosphatase (AP) were also studied. The production of significantly higher amounts of in vivo generation of ROS leads to membrane damage and oxidative stress. Presences of NPs and NPs agglomerates/aggregates were also the contributing factors in mechanical damaging the membranes and physiological structure of thyroid axis. The increased activities of CAT, mu-GST, and AP confirmed the increased oxidative stress, possible DNA, and metabolic alterations, respectively. The excessive production of in vivo ROS leads to severe apoptosis in head, eye, and heart region confirming that malformation leads to malfunctioning of hypothalamus pituitary axis. ROS-induced oxidative DNA damage by formation of 8-OHdG DNA adducts elaborates the genotoxicity potential of CoFe O NPs. This study will help us to better understand the risk and assessment of endocrine disrupting potential of nanoparticles. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 2068-2080, 2016.

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Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae

Cited by 102 publications

References 70 publications

Effects of Silver Nanoparticles on Thyroid Gland Structure and Function in Female Rats

Effects of Silver Nanoparticles on Thyroid Gland Structure and Function in Female Rats

Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

Assessment of thyroid endocrine system impairment and oxidative stress mediated by cobalt ferrite (CoFe₂O₄) nanoparticles in zebrafish larvae

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Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae

Cited by 102 publications

References 70 publications

Effects of Silver Nanoparticles on Thyroid Gland Structure and Function in Female Rats

Effects of Silver Nanoparticles on Thyroid Gland Structure and Function in Female Rats

Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

Assessment of thyroid endocrine system impairment and oxidative stress mediated by cobalt ferrite (CoFe2O4) nanoparticles in zebrafish larvae

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Product

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Assessment of thyroid endocrine system impairment and oxidative stress mediated by cobalt ferrite (CoFe₂O₄) nanoparticles in zebrafish larvae