Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction

Abstract

Korean ginseng and mountain ginseng (Panax ginseng CA Meyer) are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract (TMGE) on male patients with erectile dysfunction (ED). A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, and the other group took 1 000 mg of placebo twice a day. The effects of the TMGE and the placebo were analyzed using the Korean version of the International Index of Erectile Function (IIEF) questionnaire. A total of 86 patients completed 8 weeks of treatment. The scores on the five domains of the IIEF after medication were significantly higher than the baseline scores in the group treated with TMGE (P < 0.05), whereas no significant improvement was observed in the placebo group (P > 0.05). Erectile function and overall satisfaction scores after medication were significantly higher in the TMGE group than in the placebo group (P < 0.05). Erectile function of patients in the TMGE-treated group significantly improved, suggesting that TMGE could be utilized for improving erectile function in male patients.

Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study

“…21 Several studies have described the clinical efficacy of ginseng and its extract for treatment of ED. 20,22 However, Jang et al 23 reported that out of 28 published articles on the effect of ginseng on the treatment of ED, only 7 articles satisfied their strict criteria of being double-blind, placebo-controlled trials. 23 The meta-analysis showed that ginseng improved sexual performance.…”

“…Moreover, some of these studies did not describe baseline comparison of ED symptoms or obtain appropriate ethical approval. [20][21][22][23][24] The clinical trial described herein was designed as a multicenter, randomized, double-blind, placebo-controlled study, addressing both the efficacy and safety of SKGB extract in men with mild-to-moderate ED.…”

“…20,22,[25][26][27] Because ginseng is not a drug that can treat severe ED, we enrolled mild-to-moderate ED patients only. We found that SKGB group showed improvement after 8 weeks of treatment by within-group analysis.…”

Nutraceuticals for Fertility and Erectile Health: A Brief Overview of What Works and What Is Worthless

“…Approximately ten randomized trials have suggested that Panax ginseng and its ginsenosides have potential efficacy in diverse areas of male sexual health [164,165,190,191]. Still, this is not meant to suggest that it is the most effective ED nutraceutical option because others (arginine combinations and citrulline) have their own advantages and disadvantages, and methodological quality of future clinical trials needs to be improved.…”

Smart Talk on Supplements and Botanicals: Maca and Other Herbs for “Sexual Enhancement”

“…A 2009 study of 86 men with ED by Kim, et al 5 found that 1 g of Panax ginseng, taken two times per day for 8 weeks, significantly improved scores on the International Index of Erectile Function compared with placebo.…”