Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro

Abiramasundari, G.; Sumalatha, K. R.; Sreepriya, M.

doi:10.1016/j.jep.2012.03.015

Cited by 60 publications

(38 citation statements)

References 17 publications

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“…42 Furthermore, a recent study has shown that TCE promotes the proliferation of osteoblast cells and mineralization of bone-like matrix on human osteoblast-like cells MG-63 and rat primary culture of osteoblasts. 43 Among the MMPs, MMP-9 plays an important role in cartilage and bone destruction in arthritic joints. 44 TCE-treated rats showed marked reduction in MMP-9 activity, but without much effect on MMP-2 activity.…”

Section: Discussionmentioning

confidence: 99%

Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage

Sannegowda

Venkatesha

Moudgil

2015

Int J Immunopathol Pharmacol

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints leading to tissue damage. Despite the availability of potent drugs including the biologics, many patients fail to respond to them, whereas others suffer adverse effects following long-term use of these drugs. Accordingly, the use of natural herbal products by RA patients has been increasing over the years. However, limited information about the mechanism of action of these natural products is a major shortcoming that prevents the widespread acceptance of herbal therapy by professionals and patients alike. In this study, we demonstrated the anti-arthritic activity of Tinospora cordifolia extract (TCE) using the rat adjuvant-induced arthritis model of human RA and elaborated the immune mechanisms underlying this effect. TCE treatment suppressed arthritic inflammation and bone and cartilage damage. The anti-inflammatory effect of TCE was mediated via reduction of the pro-inflammatory cytokines such as: IL-1β, TNF-α, IL-6, and IL-17; the frequency of IL-17-producing T cells; and the production of chemokines such as RANTES. Furthermore, TCE treatment limited bone damage by shifting the balance of mediators of bone remodeling (e.g., receptor activator of nuclear factor-kB ligand [RANKL] and MMP-9) in favor of anti-osteoclastic activity. Our results suggest that TCE and its bioactive components should be evaluated for their utility as therapeutic adjuncts to conventional drugs against RA.

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Section: Discussionmentioning

confidence: 99%

Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage

Sannegowda

Venkatesha

Moudgil

2015

Int J Immunopathol Pharmacol

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“…stem extracts increased proliferation, differentiation and mineralization of bone like matrix on osteoblast model systems in vitro, suggesting its potential influence on osteogenesis along with anti-arthritic activity. 26 Exact reason behind bone erosion in RA is not fully understood but formation of reactive oxygen species (ROS) and lipid peroxides as a result of disease activity are considered as a major factor. Therapeutic administration of antioxidants can mop up free radicals and reduce lipid per-oxidation which exacerbates inflammation and degeneration in RA.…”

Section: Discussionmentioning

confidence: 99%

Critical Review on Ellumnishadi Lepa: An Ayurvedic Topical Applicant in Knee Joint Swellings Associated With Rheumatoid Arthritis

Nair¹,

Nair²,

Deep³

et al. 2018

Int. J. Res. Ayurveda Pharm.

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ABSTRACT'Ellumnishadi lepa' is a poly herbal topical dosage form mentioned in 'Chikitsa Manjari', which is a compilation of clinical observations and simple formulations that were used by traditional Ayurveda practitioners of Kerala. As per the textbook, the lepa (topical applicant) is indicated in knee joint swellings associated with Vatarakta (a disease condition caused due to dangerous amalgamation of vitiated Vata (bio force) and Rakta (blood)). The ingredients of the formulation are to be boiled in milk, made into a paste and applied locally over the afflicted area with q uantity sufficient ghee. Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease afflicting majority of synovial joints. Although Rheumatoid arthritis cannot be correlated to a single entity in Ayurveda, clinical protocols and medicaments prescribed for Vatarakta are used by clinicians in different stages of rheumatoid arthritis. Ingredients in the prescribed lepa are having proven anti-inflammatory, anti-rheumatic and antioxidant activities which can combat the pathology in RA. Ellumnishadi lepa application can be used as an effective complimentary treatment along with main stream management strategies in providing satisfactory relief from knee joint swellings associated with degenerative changes in Rheumatoid arthritis.

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“…A recent study revealed that osteoblasts enhance mineral deposition when exposed to 12.5–25 μg/ml of tinosfora cordofila. This effect was measured by monitoring alkaline phosphatase and calcium depsotion in rat primary osteoblast as well as human osteoblast-like MG-63 cells in the presence of Tinosfora cordofila [158]. These results all together demonstrate the potential of tinosfora cordofila to be used in tissue engineering applications to concurrently enhance bone repair and alleviate inflammatory response.…”

Section: Natural Anti-inflammatory Compounds To Modulate Inflammatmentioning

confidence: 98%

“…Human osteoblast-like cells and primary rat osteoblastic cells proliferated at a higher rate and accelerated mineral content deposition when exposed to a Tinosfora cordifolia extract [150, 157]. A recent study revealed that osteoblasts enhance mineral deposition when exposed to 12.5–25 μg/ml of tinosfora cordofila.…”

Section: Natural Anti-inflammatory Compounds To Modulate Inflammatmentioning

confidence: 99%

Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds

Yanez

Blanchette

Jabbarzadeh

2018

CPD

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Tissue engineering offers a promising strategy to restore injuries resulting from trauma, infection, tumor resection, or other diseases. In spite of significant progress, the field faces a significant bottleneck; the critical need to understand and exploit the interdependencies of tissue healing, angiogenesis, and inflammation. Inherently, the balance of these interacting processes is affected by a number of injury site conditions that represent a departure from physiological environment, including reduced pH, increased concentration of free radicals, hypoglycemia, and hypoxia. Efforts to harness the potential of immune response as a therapeutic strategy to promote tissue repair have led to the identification of natural compounds with significant anti-inflammatory properties. This article provides a concise review of the body’s inflammatory response to biomaterials and describes the role of oxygen as a physiological cue in this process. We proceed to highlight the potential of natural compounds to mediate inflammatory response and improve host-graft integration. Herein, we discuss the use of natural compounds to map signaling molecules and checkpoints that regulate the cross-linkage of immune response and skeletal repair.

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Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro

Cited by 60 publications

References 17 publications

Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage

Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage

Critical Review on Ellumnishadi Lepa: An Ayurvedic Topical Applicant in Knee Joint Swellings Associated With Rheumatoid Arthritis

Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds

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