Effects of time of progesterone supplementation on embryo development and interferon-τ production in the cow

Mann, G.E.; Fray, Martin; Ge, Lan

doi:10.1016/j.tvjl.2004.12.005

Cited by 219 publications

(147 citation statements)

References 6 publications

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“…Greater concentrations of P 4 before and after breeding are associated with enhanced fertility (Folman et al, 1973) and embryonic survival (Mann et al, 2006). However, the present study showed no effects of feeding 0.22 kg of rumen-inert source of SFA or PUFA on serum concentrations of P 4 compared with feeding a non-fat control supplement.…”

Section: Discussioncontrasting

confidence: 65%

Effects of supplementation of calcium salts of polyunsaturated fatty acids on serum concentrations of progesterone and insulin of pregnant dairy cows

et al. 2014

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-Forty-five non-lactating, pregnant Holstein animals (18 heifers and 27 multiparous cows; BW = 561±114 kg; BCS = 2.9±0.3; days pregnant = 110±56 d) were stratified by initial BW and BCS, and randomly assigned to receive daily (as-fed basis) 0.50 kg of ground corn plus 0.22 kg of kaolin (CON), calcium salts of saturated fatty acids (SFA) or polyunsaturated fatty acids (PF) for 14 d. Blood samples were collected on days 0, 7 and 14, immediately prior to (0 h) and 3, 6, 9 and 12 h after feeding, to determine the serum concentrations of P 4 and insulin. No treatment effects were detected for serum concentrations of P 4 (5.52, 6.13 and 5.63±0.41 ng/mL for CON, SFA and PF, respectively). No treatment effects were detected for serum concentrations of insulin (11.5, 10.5 and 10.1±1.43 µIU/mL for CON, SFA and PF, respectively). Heifers had greater serum concentrations of P 4 than multiparous cows (6.35 vs. 5.16±0.42 ng/mL), but lower serum concentrations of insulin (7.0 vs. 14.4±1.49 µIU/mL). Feeding 0.22 kg of calcium salts of polyunsaturated fatty acids is not sufficient to increase the serum concentrations of P 4 and insulin of non-lactating, pregnant dairy cows.

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Section: Discussioncontrasting

confidence: 65%

Effects of supplementation of calcium salts of polyunsaturated fatty acids on serum concentrations of progesterone and insulin of pregnant dairy cows

et al. 2014

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“…The rationale for progesterone supplementation in animals with low postovulatory progesterone concentrations is to create an embryotrophic environment allowing the embryo to grow, develop and survive, until, for example, it is capable of preventing luteolysis by secretion of the luteotrophin, INF-t ). Mann et al (2006) reported a 4-fold increase in trophoblast length together with a 6-fold increase in uterine concentrations of INF-t in non-lactating cows supplemented with progesterone between days 5 and 9, while no effect was seen in cows supplemented between days 12 to 16. The actions of progesterone may be mediated either by a direct effect on the embryo or indirectly via the uterus or possibly both.…”

Section: Mechanisms Of Action Of Progesteronementioning

confidence: 96%

“…Progesterone affects the volume of uterine secretions (Garrett et al, 1988) and the rate of conceptus development (Garrett et al, 1988;Green et al, 2005) as well as the ability of embryos to produce the luteolysis inhibitor interferon-tau (IFN-t) (Garrett et al, 1988;Kerbler et al, 1997;Mann et al, 2006) and the timing and strength of PGF2a (Mann and Lamming, 1995;Mann et al, 1998). The rationale for progesterone supplementation in animals with low postovulatory progesterone concentrations is to create an embryotrophic environment allowing the embryo to grow, develop and survive, until, for example, it is capable of preventing luteolysis by secretion of the luteotrophin, INF-t ).…”

Section: Mechanisms Of Action Of Progesteronementioning

confidence: 99%

Effect of progesterone on embryo survival

Morris

Diskin

2008

Animal

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Increased genetic selection over the past 40 years has resulted in a dairy cow with an improved biological efficiency for producing milk but with an associated reduced fertility. Embryo loss is the greatest factor contributing to the failure of a cow to conceive. The extent and timing of embryo loss indicates that 70% to 80% of this loss occurs in the first 2 weeks after artificial insemination (AI). This is the period when a number of critical phases in embryo development occur and where protein accretion, substrate utilization and embryo metabolism increase dramatically. During this time the early embryo is completely dependent on the oviduct and uterine environment for its survival and it is likely that the embryo requires an optimal uterine environment to ensure normal growth and viability. There is increasing evidence of an association between the concentration of systemic progesterone and early embryo loss and that progesterone supplementation of cows, particularly those with low progesterone, can reduce this loss. While progesterone is known to affect uterine function and embryo growth, little is known about the uterus during the period of early embryo loss and how this is affected by changes in the concentration of systemic progesterone. The expression of uterine genes encoding the transport protein retinol binding protein (RBP) and the gene for folate binding protein (FBP) appear to be sensitive to changes in systemic progesterone, particularly during the early luteal phase of the cycle. Uterine concentrations of proteins also seem to be regulated by stage of cycle; however, their relationship with the systemic concentration of progesterone is unclear. There is an urgent need to characterize the uterine environment from a functional perspective during the early part of the luteal phase of the cycle, particularly in the high-producing cow, in order to understand the factors contributing to early embryo loss and in order to devise strategies to minimize or reduce this loss.

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“…Although IVP embryo is a model widely used to study the effect of P4 supplementation on embryo development (MANN et al, 2006;LONERGAN et al, 2007;CARTER et al, 2008;, in our study supplementation of P4 for lactating recipient dairy cows had negative effect on fertility. Recipients supplemented with P4 had 50% or less P/ET than the control group.…”

Section: Discussionmentioning

confidence: 52%

“…High concentration of circulating P4 on metestrus or early diestrus has been associated with advancement of conceptus elongation O'HARA et al, 2014), an associated increase in interferon-τ (IFN) FRAY;LAMMING, 2006). The IFN is the signal for maternal recognition of pregnancy in ruminants associated with prevention of luteolysis.…”

Section: Bastos; Wiltbank 2010)mentioning

confidence: 99%

Exogenous hormonal manipulation to increase reproductive efficiency in dairy cows

Júnior¹,

Jerônimo²

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Effects of time of progesterone supplementation on embryo development and interferon-τ production in the cow

Cited by 219 publications

References 6 publications

Effects of supplementation of calcium salts of polyunsaturated fatty acids on serum concentrations of progesterone and insulin of pregnant dairy cows

Effects of supplementation of calcium salts of polyunsaturated fatty acids on serum concentrations of progesterone and insulin of pregnant dairy cows

Effect of progesterone on embryo survival

Exogenous hormonal manipulation to increase reproductive efficiency in dairy cows

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