Effects of time of estrogen deprivation on anxiety-like behavior and GABAA receptor plasticity in ovariectomized rats

Daendee, Suwaporn; Thongsong, Boonrit; Kalandakanond-Thongsong, Sarinee

doi:10.1016/j.bbr.2013.03.008

Cited by 25 publications

(19 citation statements)

References 79 publications

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“…The GABA A R α3, α4, δ, π, and γ2-subunits upregulation associated with the depletion of implanted estrogen and progesterone hormones in this study has also been reported in human and rat brains (Genazzani et al, 2000;Maggi and Perez, 1984). The depletion of estrogen following ovariectomy in rats increases the GABA A receptor α2-, α3and α4-subunits expression in the midbrain (Daendee et al, 2013). Several studies on progesterone withdrawal showed a significant increase in the expression of GABA A R α4 and δ-subunits in hippocampus and midbrain of rats (Gulinello et al, 2002;Lovick et al, 2005;Smith et al, 1998a;Smith et al, 1998b;Smith et al, 2007).…”

Section: Discussionsupporting

confidence: 81%

Ovarian steroid withdrawal results in GABAA receptor upregulation in the photoperiodic neuroendocrine pathways of the turkey hen

Chaiworakul

Kosonsiriluk

Mauro

et al. 2017

General and Comparative Endocrinology

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The mechanism(s) underlying photorefractoriness in temperate zone seasonally breeding birds remains undetermined. Our recent findings reveal a link between the upregulation of GABA receptors (GABARs) in the premammillary nucleus (PMM) and the state of photorefractoriness. Gonadal steroid levels fluctuate during the breeding season; increasing after gonadal recrudescence and declining sharply once gonadal regression begins. Here, we examined the effect of gonadal steroid withdrawal on the expression of GABARs in the turkey PMM. Exogenous ovarian steroids were administered and then withdrawn from turkey hens to mimic the decline of ovarian steroids levels at the end of a breeding season. The upregulation of GABAR α3, α4, δ, π, and γ2-subunits was observed in the PMM of the steroid withdrawal group when compared to the non-steroid treatment group. The level of tyrosine hydroxylase, photopigment melanopsin, and circadian clock genes in the PMM of the steroid withdrawal group resembled the levels observed in the natural photorefractory hens and were significantly lower than those of the short-day light stimulated group. A reduction in gonadotropin-releasing hormone-I mRNA expressed within the nucleus commissurae pallii was also observed in hens undergoing steroid withdrawal. These results suggest that the natural decline in circulating ovarian steroid levels may modulate the GABAergic system in the PMM through the upregulation of GABA receptors. This, in turn, could diminish the reproductive neuroendocrine responses to light and favor a condition resembling the state of photorefractoriness.

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Section: Discussionsupporting

confidence: 81%

Ovarian steroid withdrawal results in GABAA receptor upregulation in the photoperiodic neuroendocrine pathways of the turkey hen

Chaiworakul

Kosonsiriluk

Mauro

et al. 2017

General and Comparative Endocrinology

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“…Although women with premature ovarian failure do not have the sudden drop in ovarian hormones that women who undergo bilateral oophorectomies experience, studies in rats and mice suggest symptoms of anxiety are worse the longer the duration of ovarian hormone deficiency (Lagunas et al 2010;de Chaves et al 2009;Citraro et al 2015). Daendee et al (Daendee et al 2013) conducted a time course of the effects of ovariectomy duration and showed that the percentage of rats exhibiting anxiety-like behavior in the elevated T maze increased from ~ 30 to ~ 60% and 90%, 2, 3, and 4 weeks after ovariectomy, respectively. Thus, ARBs may also be neuroprotective in women with premature ovarian failure given that their life-long exposure to ovarian hormone deficiency is increased compared to women who experience normal menopause.…”

Section: Discussionmentioning

confidence: 99%

The Angiotensin Type 1 Receptor Antagonist Losartan Prevents Ovariectomy-Induced Cognitive Dysfunction and Anxiety-Like Behavior in Long Evans Rats

Campos

Souza

et al. 2020

Cell Mol Neurobiol

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Women who have bilateral oophorectomies prior to the age of natural menopause are at increased risk of developing mild cognitive decline, dementia, anxiety, and depressive type disorders. Clinical and animal studies indicate angiotensin type 1 receptor (AT 1 R) blockers (ARBs) have blood pressure (BP)-independent neuroprotective effects. To investigate the potential use of ARBs in normotensive women at increased risk of developing neurocognitive problems, we studied a rat model of bilateral oophorectomy. Long Evans rats were sham-operated (Sham) or ovariectomized (Ovx) at 3 months of age and immediately treated continuously with vehicle (Veh) or the ARB losartan (Los) for the duration of the experiment. In contrast to many hypertensive rat models, ovariectomy did not increase mean arterial pressure (MAP) in these normotensive rats. Ovariectomized rats spent less time in the open arms of the elevated plus maze (EPM) [(% total time): Veh, 34.1 ± 5.1 vs. Ovx, 18.7 ± 4.4; p < 0.05] and in the center of the open field (OF) [(s): Veh, 11.1 ± 1.7 vs. Ovx, 6.64 ± 1.1; p < 0.05]. They also had worse performance in the novel object recognition (NOR) test as evidenced by a reduction in the recognition index [Veh, 0.62 ± 0.04 vs. Ovx, 0.45 ± 0.03; p < 0.05]. These adverse effects of ovariectomy were prevented by Los. Losartan also reduced plasma corticosterone in Ovx rats compared to Veh treatment [(ng/mL): Ovx-Veh, 238 ± 20 vs. Ovx-Los, 119 ± 42; p < 0.05]. Ovariectomy increased AT 1 R mRNA expression in the CA3 region of the hippocampus (Hc) [(copies x 10 6 /µg RNA): Sham-Veh, 7.15 ± 0.87 vs. 9.86 ± 1.7; p < 0.05]. These findings suggest the neuroprotective effects of this ARB in normotensive Ovx rats involve reduction of plasma corticosterone and blockade of increased AT 1 R activity in the hippocampus. These data suggest ARBs have therapeutic potential for normotensive women at increased risk of developing cognitive and behavioral dysfunction due to bilateral oophorectomy prior to the natural age of menopause.

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“…In 2013, Daendeea S [25] developed a study whose objective was to examine the effects of estrogen deprivation time on anxiety related behaviour and on expressions of the subunit gene of the GABAA receptor in ovariectomized rats. The GABAA receptor was of special interest, since it was shown that it is influenced by estrogens.…”

Section: Randomized Clinical Trialsmentioning

confidence: 99%

Estrogen and Transdiagnostics: A Systematic Review

Almeida¹,

Nardi²

2016

J Depress Anxiety

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perform a systematic review, making reference to the scientific literature on female patients with estrogen fluctuations which individuals influence the occurrence, intensity, expression of different disorders of mood or anxiety (transdiagnostic). SourcesSearches were carried out in the ISI Web of Science and PubMed databases, utilizing the terms "estrogen", "anxiety disorder" and "mood disorder". The search was performed in May and June of 2015, with a temporal restriction of 10 years in both databases. Articles that were reviews or repeated were excluded, as were studies that were not available in English. Study SelectionA total of 1060 references were found, 673 on PubMed and 387 on ISI Web of Science, among which 11 were duplicates and 52 were in languages other than English. Of the remaining 997 references, 118 were excluded by prior review, 114 for having incoherent abstracts, 727 by title and 20 by eligibility, leaving a total of 16 articles to compose this review. The eligibility criteria were the hormone physiological relation with the prevalence of the anxiety and mood disorders. AbstractObjective: To evaluate, through systematic review, whether the role of estrogen influences the onset of disorders in anxiety and depression. Data Sources: The search was performed in two databases, ISI Web of Science and PubMed, using the terms estrogen, anxiety and mood. Study selection:The search produced 1060 references. Those that were repeated or not written in English were excluded. After analysis of the abstracts, 38 were selected to have their texts read, of which 18 were chosen for the execution of this review. Data collection:The PubMed and ISI Web of Science articles were extracted in June 2015. Moreover, the study was also restricted to articles that involved adult patients and were elaborated between 2005 and 2015.Results: There were six case-control observational studies, followed by four randomized clinical trials. The results in smaller quantities in the review were: three retrospective cohort observational studies and three cross-sectional studies, followed by one prospective cohort observational study. A letter to an editor was also included. The result that stood out in the review was the finding that women are twice as likely to suffer from disturbances of anxiety or mood, such as generalized anxiety disorder, panic disorder, post-traumatic stress disorder and bipolar disorder. Conclusion:Some women there is a greater vulnerability to hormonal oscillations of estrogen (in pre-menstrual and postpartum periods and in the pre-menopause) leading to the aforementioned disorders.

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Effects of time of estrogen deprivation on anxiety-like behavior and GABAA receptor plasticity in ovariectomized rats

Cited by 25 publications

References 79 publications

Ovarian steroid withdrawal results in GABAA receptor upregulation in the photoperiodic neuroendocrine pathways of the turkey hen

Ovarian steroid withdrawal results in GABAA receptor upregulation in the photoperiodic neuroendocrine pathways of the turkey hen

The Angiotensin Type 1 Receptor Antagonist Losartan Prevents Ovariectomy-Induced Cognitive Dysfunction and Anxiety-Like Behavior in Long Evans Rats

Estrogen and Transdiagnostics: A Systematic Review

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