Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle

Ayala, Carolina; Pennacchio, Gisela E.; Soaje, Marta; Carreño, Norma Beatriz; Bittencourt, Jackson C.; Jahn, Graciela A.; Celis, Marı́a Ester; Valdéz, Susana R.

doi:10.1016/j.peptides.2013.08.016

Cited by 9 publications

(9 citation statements)

References 69 publications

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“…; Ayala et al . ). In vivo experiments proved that estradiol regulated luteal function by assisting the uptake of cholesterol for P4 synthesis in rats (Kim & Greenwald ; Wang et al .…”

Section: Discussionmentioning

confidence: 97%

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

Wei

Fedail

Kong

et al. 2017

Animal Science Journal

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To expand our understanding of the roles of thyroid hormones on female reproduction, we induced hypo- and hyper-T rat models to investigate the roles of thyroid hormones on estrous cyclicity, as well as the antioxidative status in the ovaries of rats. In the current study, our data show that hypothyroidism (hypo-T) and hyperthyroidism (hyper-T) led to significantly reduced body weights and ovarain weights and delayed vaginal opening day. For hyper-T, thyroxine (T4), tri-iodothyronine (T3), progesterone (P4) and follicle-stimulating hormone (FSH) were significantly increased, while estradiol (E2) and luteinizing hormone (LH) were significantly decreased. For hypo-T rats, serum levels of total T4 and T3, E2, P4, FSH and LH were significantly increased, while concentrations of E2 and LH were significantly decreased. For ovary morphology, the numbers of secondary and antral follicles were significantly decreased with more atretic antral follicles and less corpora lutea in both hyper- and hypo-T groups. Both hyper-T and hypo-T treatment significantly decreased the expressions of thyroid hormone receptor α1 in the ovary. Hypo-T significantly reduced nitric oxide (NO), total NO synthase (tNOS), inducible NOS and constitutive NOS activities, but hyper-T increased them. For antioxidative parameters, hypo-T and hyper-T treatment significantly increased malondialdehyde (MDA) contents. The activities of both glutathione peroxidase (GSH-Px) and catalase (CAT) significantly decreased in the hypo-T group but increased in the hyper-T group. Total superoxide dismutase (T-SOD) activity was significantly increased in the hyper-T group. In summary, thyroid hormones alter estrous cyclicity and antioxidative status in the ovary of the rat may act through the NOS signaling pathway.

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“…; Ayala et al . ). In vivo experiments proved that estradiol regulated luteal function by assisting the uptake of cholesterol for P4 synthesis in rats (Kim & Greenwald ; Wang et al .…”

Section: Discussionmentioning

confidence: 97%

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

Wei

Fedail

Kong

et al. 2017

Animal Science Journal

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“…One interesting observation is that both experimental conditions, hypoT and hyperT, also induce responses of the peptidergic neurons and fibers containing NEI in hypothalamic areas additional to those described before. In a previous paper we informed that the NEI concentration measured in the perifornical part of the lateral hypothalamus (PeFLH), organum vasculosum of the lamina terminalis (OVLT) and anteroventral periventricular nucleus (AVPV) in the euthyroid female rat follows a cyclic pattern, and this characteristic is altered under the hypoT or hyperT status [17], suggesting that NEI is regulated by pituitary and ovarian hormones [17].…”

Section: Discussionmentioning

confidence: 99%

“…As the PLH is a fairly large region ranging from -1.20 mm to -4.56 mm from Bregma, we decided to determine the effects of hypo-and hyperthyroidism on NEI precursor (ppMCH) and TH by the detection of its respective mRNA expression in the three hormonal conditions: hypoT, hyperT, and euthyroid or control animals. PLH was obtained by microdissection of 1 mm thickness coronal brain slices obtained at -2,16 and 2,76 from Bregma in an aluminum cold plate at 4 ºC [17] and processed for total RNA extraction. The mRNA NEI precursor showed a significant increase (p<0.01) in gene expression in the hypoT rats (Fig.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…TRH-R1 mRNA is expressed in restricted regions of the hypothalamus including the lateral hypothalamus and the posterior hypothalamic area to control neuroendocrine and autonomous functions and the regulation of the HPT axis [15]. Our previous works reported that hypothyroidism and hyperthyroidism affects NEI content in selected brain areas of male and female rats [16,17].…”

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

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Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat

et al. 2019

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“…1 and 2, Tables 3 and 4), the peduncular part of the lateral hypothalamus (PLD) and the tuberal part of the lateral hypothalamus (TuLH) were identified adjacent to the rostral region of E5 (E5r), and these nuclei have been shown to be involved in the hypothalamic-pituitary-gonadal axis (Ayala et al, 2013), GABAAdependent feeding behavior (Turenius et al, 2009), and hypoglycemia-induced feeding behavior via orexin (Griffond et al, 1999). Therefore, the ventral part (PMV) and dorsal part (PMD) of the premammillary nuclei were also found nearby to the ventral aspect of the caudal region of E5 (E5v) (Figs.…”

Section: Discussionmentioning

confidence: 99%

Distribution of histaminergic neuronal cluster in the rat and mouse hypothalamus

Moriwaki

Chiba

Wei

et al. 2015

Journal of Chemical Neuroanatomy

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Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histaminergic neurons arise in the posterior mesencephalon during the early embryonic period and gradually develop into two histaminergic substreams around the lateral area of the posterior hypothalamus and the more anterior peri-cerebral aqueduct area before finally forming an adult-like pattern comprising five neuronal clusters, E1, E2, E3, E4, and E5, at the postnatal stage. This distribution of histaminergic neuronal clusters in the rat hypothalamus appears to be a consequence of neuronal development and reflects the functional differentiation within each neuronal cluster. However, the close linkage between the locations of histaminergic neuronal clusters and their physiological functions has yet to be fully elucidated because of the sparse information regarding the location and orientation of each histaminergic neuronal clusters in the hypothalamus of rats and mice. To clarify the distribution of the five-histaminergic neuronal clusters more clearly, we performed an immunohistochemical study using the anti-HDC antibody on serial sections of the rat hypothalamus according to the brain maps of rat and mouse. Our results confirmed that the HDC-immunoreactive (HDCi) neuronal clusters in the hypothalamus of rats and mice are observed in the ventrolateral part of the most posterior hypothalamus (E1), ventrolateral part of the posterior hypothalamus (E2), ventromedial part from the medial to the posterior hypothalamus (E3), periventricular part from the anterior to the medial hypothalamus (E4), and diffusely extended part of the more dorsal and almost entire hypothalamus (E5). The stereological estimation of the total number of HDCi neurons of each clusters revealed the larger amount of the rat than the mouse. The characterization of histaminergic neuronal clusters in the hypothalamus of rats and mice may provide useful information for further investigations.

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Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle

Cited by 9 publications

References 69 publications

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats

Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat

Distribution of histaminergic neuronal cluster in the rat and mouse hypothalamus

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