Effects of thyroid status on thyroid autoimmunity expression in euthyroid and hypothyroid patients with Hashimoto's thyroiditis

Rieu, M; Richard, A; Rosilio, Myriam; Laplanche, Sophie; Ropion, Veronique; Fombeur, J. P.; Berrod, Jean-Louis

doi:10.1111/j.1365-2265.1994.tb02494.x

Cited by 46 publications

(35 citation statements)

References 37 publications

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“…This may be important since patients with diffuse goiters and HT respond well to suppressive therapy with thyroxine. 9 Rieu et al 10 report that in Hashimoto's thyroiditis, levothyroxine therapy decreases the titers of some circulating thyroid autoantibodies but long-term follow-up studies with thyroxine therapy would be required to see if decreasing antibody titers would lead to clinical benefit.…”

Section: Discussionmentioning

confidence: 99%

Chronic Lymphocytic (Hashimoto's) Thyroiditis in Kuwait Diagnosed by Fine Needle Aspirates

et al. 1995

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A retrospective analysis of 4185 consecutive fine needle aspirates (FNA) of the thyroid over an eight year period at a teaching hospital in Kuwait revealed that 14.3% of all the aspirates had features of chronic lymphocytic (Hashimoto's) thyroiditis (HT). The proportion of patients with HT showed a slight increase in the last two years but the pattern of clinical presentation has remained unchanged. Hashimoto's thyroiditis was most prevalent in the age group from 16 to 35 and the majority of young patients with Hashimoto's thyroiditis presented with diffuse goiter (DG) whereas multinodular goiter (MNG) and solitary thyroid nodule (STN) were more common in the older age group. Of patients who presented with STN, the most common abnormality on thyroid scan was a "cold nodule". Functional disturbances (hypo and hyperthyroidism) occurred less frequently in patients presenting as STN than in patients presenting with DG or MNG. We conclude that FNA is indicated in all young patients with diffuse goiter in this region in order to facilitate early detection and initiation of suppressive thyroxine therapy. Further, when young patients present with "cold" solitary nodules of the thyroid, HT is a more common cause than a thyroid carcinoma in Kuwait. Ann Saudi Med 1995;15(4) It has been our impression over the last two years that in Kuwait, chronic lymphocytic (Hashimoto's) thyroiditis (HT) presents at an earlier age and that a relatively greater proportion of patients with this disorder present as solitary nodules. In order to verify these impressions, we performed a retrospective analysis of all the fine needle aspirate (FNA) reports and the relevant clinical information from January 1986 to December 1993. We felt that such an analysis would give us information on the spectrum of HT in Kuwait, whether it differs from the spectrum of HT in other parts of the world and whether it has changed over the years. MethodsMubarak Al Kabeer Hospital is a tertiary care university teaching hospital in Kuwait and one of the major centers for fine needle aspiration cytology in this country. Information on all thyroid FNAs performed in this hospital was available from January 1986. The relevant clinical information available in the request forms and in the cytology registry was collected and analyzed. On the basis of clinical examination, patients were diagnosed to have a) diffuse goiter; b) multinodular goiter; and c) solitarythyroid nodule. Fine needle aspirates on these patients were diagnosed as follicular neoplasm, carcinoma, Hashimoto's thyroiditis or other benign lesions of the thyroid. When the FNA smears showed moderate to abundant lymphoid infiltrate with a variable degree of Hurthle cell metaplasia and follicular destruction, the diagnosis of Hashimoto's thyroiditis was suggested. The diagnosis of a follicular neoplasm was made when numerous follicular cells were seen in a microfollicular pattern with scant colloid. FNA smears were categorized as carcinoma when cytologic features suggestive of a papillary or undifferentiated c...

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Section: Discussionmentioning

confidence: 99%

Chronic Lymphocytic (Hashimoto's) Thyroiditis in Kuwait Diagnosed by Fine Needle Aspirates

et al. 1995

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“…A possible mechanism behind this effect of T 3 could be stimulation of an already ongoing immune process at this age. The biphasic time-dependent effect of T 3 on the prevalence of thyroiditis may reflect the dilemma of whether or not treatment with thyroid hormones might enhance an ongoing immune process of human autoimmune thyroiditis (9,10).…”

Section: Body Weight (G) (Mean^sem) (N)mentioning

confidence: 99%

“…In humans, the influence of thyroid status on thyroid autoimmunity is controversial (9,10). However, the comparable pathogenetic mechanisms of AIT and T1DM and the reduction in the incidence of T1DM by changed b-cell activity (11 -13) caused us to examine whether changed thyroid activity (i.e.…”

Section: Introductionmentioning

confidence: 99%

Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats

#M-L|#Hartoft-Nielsen|#

Kaas

et al. 2004

European Journal of Endocrinology

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Objective: Changes in the functional state of beta cells by neonatal stimulation or adolescent suppression have reduced the incidence of type 1 diabetes mellitus in animal models. The aim of this study was to evaluate the effect of manipulation of the activity of the thyroid gland by neonatal stimulation or by adolescent suppression on the prevalence of spontaneous autoimmune thyroiditis (AIT) in rats. Methods: Bio-Breeding/Worcester (BB) rats were treated neonatally with sodium iodine (NaI) or thyroid stimulating hormone (TSH), or during adolescence by triiodothyronine (T 3 ), and the lymphocytic infiltration in the thyroid gland was evaluated. Results: Neonatal treatment with NaI decreased the prevalence of AIT to 32^9% compared with 66^5% in the controls (P , 0.002), mainly caused by a reduction among the female rats (13^9% vs 52^8%, P , 0.006). TSH had no effect. Post neonatal suppression of the thyroid gland by T 3 had a biphasic response. Early in adolescence the overall prevalence was 14^7% compared with 66^5% in the controls (P , 10 25 ); for female rats AIT was prevented (0^0%) compared with 52^8% in the controls (P , 0.0003) and in male rats the values were 29^13% compared with 80^6% in the controls (P , 0.001). Treatment with T 3 later in adolescence increased the overall prevalence to 81^7% compared with 66^5% in the controls (not significant). For female rats the prevalence increased to 78^9% compared with 52^8% in the controls (P ¼ 0.04). The degree of thyroiditis among the affected animals was similar in all groups. Conclusion: Neonatal stimulation of the thyroid gland by iodine or early adolescent suppression by T 3 reduced the prevalence of AIT whereas T 3 given later increased the prevalence of thyroiditis in rats.

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“…A 1-year controlled study of thyroxine therapy in both euthyroid and hypothyroid HD patients found that thyroid antibody levels decreased in both subject groups 24 . The thyroxine effects on thyroid function and its status were interpreted as having modulated autoimmunity expression in HD 23,24 .…”

Section: Hypothesis Raised: Could Thyroxine Treatment Diminish Risk Omentioning

confidence: 99%

“…The thyroxine effects on thyroid function and its status were interpreted as having modulated autoimmunity expression in HD 23,24 . The prophylactic effect of levothyroxine therapy in euthyroid HD patients was tested in a controlled 1-year study of 10 treated versus 11 untreated patients 25 .…”

Section: Hypothesis Raised: Could Thyroxine Treatment Diminish Risk Omentioning

confidence: 99%

A 50-year Revisit of the Initiation and Associations of Hashimoto’s Disease: Might Findings Conform to a Concept of Multifactorial Physiopathologic Transitions?

Masi

2013

J Rheumatol

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Effects of thyroid status on thyroid autoimmunity expression in euthyroid and hypothyroid patients with Hashimoto's thyroiditis

Cited by 46 publications

References 37 publications

Chronic Lymphocytic (Hashimoto's) Thyroiditis in Kuwait Diagnosed by Fine Needle Aspirates

Chronic Lymphocytic (Hashimoto's) Thyroiditis in Kuwait Diagnosed by Fine Needle Aspirates

Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats

A 50-year Revisit of the Initiation and Associations of Hashimoto’s Disease: Might Findings Conform to a Concept of Multifactorial Physiopathologic Transitions?

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