Effects of thyroid hormone on coenzyme Q and other free radical scavengers in rat heart muscle

Mano, Takamitsu; Sinohara, R; Sawai, Yoshikuni; Oda, Noriko; Nishida, Yoshio; Mokuno, T; Kotake, Motoko; Hamada, Moritsugu; Masunaga, Rumi; Nakai, Asami; Nagasaka, Akio

doi:10.1677/joe.0.1450131

Cited by 55 publications

(45 citation statements)

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“…They can cause many changes in the number and activity of mitochondrial respiratory chain components. This may result in the increased generation of reactive oxygen species (ROS) [2,3]. Oxidative stress is a general term used to describe a state of damage caused by ROS [4].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Petrulea¹,

Muresan²,

Duncea³

2012

Antioxidant Enzyme

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Petrulea¹,

Muresan²,

Duncea³

2012

Antioxidant Enzyme

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“…The two main types of SOD are Mn-SOD and Cu/Zn-SOD. In this study, we investigated the changes in lipid peroxide (LPO) concentration along with changes in superoxide and LPO metabolism in cardiac muscles obtained from hyper-and hypothyroid rats (Mano et al 1995b). In addition, we measured the tissue concentrations of Mn-SOD, Cu/Zn-SOD, XOD, glutathione peroxidase (GSH-PX) and catalase to determine whether they are modulated by lipid peroxidation.…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status

Shinohara¹,

Mano²,

Nagasaka³

et al. 2000

Journal of Endocrinology

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Free radicals, hydroxyperoxides and H 2 O 2 are all known to damage cell components. This study was designed to compare the concentrations of hydroxyperoxide and free radical scavengers in the cardiac muscles of old rats in the hyper-or hypothyroid condition, to determine whether rates of peroxidation would differ with age, thyroid status, or both.Rats were rendered hyper-or hypothyroid by administration of -thyroxine or methimazole for 4 weeks. Among the old rats, the lipid peroxide (LPO) concentrations, measured as thiobarbituric acid (TBA) reactants, were significantly greater in the hyperthyroid than in the euthyroid state and the LPO concentrations measured as TBA+Fe 3+ reactants, which may be precursors of LPO, were significantly greater in the hyperthyroid state, whereas in young rats, the LPO concentrations measured by TBA or TBA+Fe 3+ methods did not differ significantly in the hyperthyroid state. In the euthyroid state, the concentration of LPO measured as TBA+Fe 3+ reactants was significantly reduced with age. Xanthine oxidase (XOD) activity also was markedly increased with age, being more pronounced in the hyperthyroid than in the euthyroid state. The Mn and Cu/Zn superoxide dismutase activities were greater in the hyperthyroid than in the euthyroid state. Glutathione peroxidase activity decreased with age in the euthyroid and, particularly, in the hyperthyroid state. Catalase activity was not affected in the old rats. Concentrations of -tocopherol in the old rats were high in the hyperthyroid state and low in the hypothyroid state, whereas the levels of -and -tocopherols in these rats were unchanged in both conditions as compared with the euthyroid state findings.Data suggest that the site of free radical generation differs in older rats, with additional shifts in the location of intracellular lipid peroxidation being noted during hyperthyroidism. Thus, as rats age, the reduction of the free radical scavenger system and the increase in LPO and XOD activities might induce myocardial dysfunction.

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“…The opposite findings were observed in hyperthyroid animals. In general, it appears that hyperthyroidism increases mitochondrial production of ROS in a variety of cells and tissues, an effect variably associated with a compensatory increase in antioxidant defenses (Asayama et al, 1987;Mano et al, 1995;Asayama and Kato, 1990;Tapia et al, 1999;Yavuz et al, 2004).…”

Section: Thyroid Hormonesmentioning

confidence: 99%

Hormonal regulation of longevity in mammals

Brown‐Borg

2007

Ageing Research Reviews

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Multiple biological and environmental factors impact the life span of an organism. The endocrine system is a highly integrated physiological system in mammals that regulates metabolism, growth, reproduction, and response to stress, among other functions. As such, this pervasive entity has a major influence on aging and longevity. The growth hormone, insulin-like growth factor-1 and insulin pathways have been at the forefront of hormonal control of aging research in the last few years. Other hormones, including those from the thyroid and reproductive system have also been studied in terms of life span regulation. The relevance of these hormones to human longevity remains to be established, however the evidence from other species including yeast, nematodes, and flies suggest that evolutionarily well-conserved mechanisms are at play and the endocrine system is a key determinant.

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Effects of thyroid hormone on coenzyme Q and other free radical scavengers in rat heart muscle

Cited by 55 publications

References 0 publications

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism

Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status

Hormonal regulation of longevity in mammals

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