Effects of thyroid endocrine manipulation on sex-related gene expression and population sex ratios in Zebrafish

Sharma, Prakash; Tang, Song; Mayer, Gregory D.; Patiño, Reynaldo

doi:10.1016/j.ygcen.2016.05.028

Cited by 39 publications

(33 citation statements)

References 55 publications

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“…For example, in zebrafish, the endocrine manipulation of THs inducing hyperthyroidism during embryonic and larval stages through exposure to thyroxine (T4) caused male-biased populations (Sharma andPatiño, 2013, Sharma et al, 2016). Conversely, the induction of hypothyroidism using goitrogens (substances that disrupt the production of THs) produced a female-biased population (Mukhi and Patino, 2006;Sharma et al, 2016). Based on these results, induced hyperthyroidism during early gonadal development stages caused testis development, but induced hypothyroidism only delayed testis development.…”

Section: Stress Brain Response To Traduces Environmental Sex Fatementioning

confidence: 99%

Stress and sex determination in fish: from brain to gonads

Castañeda-Cortés¹,

Fernandino²

2021

Int. J. Dev. Biol.

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Fish present remarkable malleability regarding gonadal sex fate. This phenotypic plasticity enables an organism to adapt changes in the environment by responding with different phenotypes. The gonad and the brain present this extraordinary plasticity. These organs are involved in the response to environmental stressors to direct the gonadal fate, inducing sex change or sex reversal in hermaphroditic and gonochoristic fish, respectively. The presence of such molecular and endocrine plasticity gives this group a large repertoire of possibilities against a continuously changing environment, resulting in the highest radiation of reproduction strategies described in vertebrates. In this review, we provide a broad and comparative view of tremendous radiation of sex determination mechanisms to direct gonadal fate. New results have established that the driving mechanism involves early response to environmental stressors by the brain plus high plasticity of gonadal differentiation and androgens as by-products of stress inactivation. In addition to the stress axis, another two major axes – the hypothalamic-pituitary-gonadal axis and the hypothalamic-pituitary-thyroid axis, which are well known to participate in the regulation of reproduction – have been proposed as reinforcing the brain-gonadal interrelationships in the fate of the gonad.

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Section: Stress Brain Response To Traduces Environmental Sex Fatementioning

confidence: 99%

Stress and sex determination in fish: from brain to gonads

Castañeda-Cortés¹,

Fernandino²

2021

Int. J. Dev. Biol.

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“…A rigorous study requires a follow up to determine if those effects can be nullified or reversed by simultaneous administration of sufficient TH to regain euthyroid condition. Interestingly, and more recently, Sharma et al (2016) evaluated the molecular mechanisms involved in T4-induced masculinization in zebrafish larvae. These authors demonstrated that T4 treatment decreases cyp19a1 (aromatase) and estrogen receptor expression, while increasing expression of masculinizing transcripts, such as amh (anti-Müllerian hormone) and ar (androgen receptor) (Sharma et al, 2016) (Fig.…”

Section: Sex Differentiationmentioning

confidence: 99%

Thyroid hormone actions on male reproductive system of teleost fish

Tovo-Neto

Rodrigues

Habibi

et al. 2018

General and Comparative Endocrinology

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Thyroid hormones (THs) play important roles in the regulation of many biological processes of vertebrates, such as growth, metabolism, morphogenesis and reproduction. An increasing number of studies have been focused on the involvement of THs in the male reproductive system of vertebrates, in particular of fish. Therefore, this mini-review aims to summarize the main findings on THs role in male reproductive system of fish, focusing on sex differentiation, testicular development and spermatogenesis. The existing data in the literature have demonstrated that THs exert their roles at the different levels of the hypothalamic-pituitary-gonadal (HPG) axis. In general a positive correlation has been shown between THs and fish reproductive status; where THs are associated with testicular development, growth and maturation. Recently, the molecular mechanisms underlying the role of THs in spermatogenesis have been unraveled in zebrafish testis. THs promote germ cell proliferation and differentiation by increasing a stimulatory growth factor of spermatogenesis produced by Sertoli cells. In addition, THs enhanced the gonadotropin-induced androgen release in zebrafish testis. Next to their functions in the adult testis, THs are involved in the gonadal sex differentiation through modulating sex-related gene expression, and testicular development via regulation of Sertoli cell proliferation. In conclusion, this mini-review showed that THs modulate the male reproductive system during the different life stages of fish. The physiological and molecular mechanisms showed a link between the thyroid and reproduction, suggesting a possibly co-evolution and interdependence of these two systems.

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“…A recent study by Sharma et al () investigated the effects of thyroid hormone treatment (T4), of goitrogen treatment (methimazole), and of a combination of both on the sex ratio of zebrafish after sexual differentiation. Furthermore, expression changes of genes involved in regulation of the HPG axis were analyzed.…”

Section: Cross‐talk Among 3 Endocrine Axes In Nonmammalian Vertebratesmentioning

confidence: 99%

“…The following key event of the first AOP segment, which is located along the HPG axis, is increased aromatase levels at the transcriptional level as well as at the enzyme level. Increased aromatase levels result in increased estrogen levels, leading to a female‐biased sex ratio, which represents the AO at the individual level (Mukhi et al ; Sharma and Patino ; Sharma et al ). Changed T3/T4 levels result in decreased 11β‐HSD levels, which is the intermediated key event for the second AOP segment.…”

Section: Cross‐talk Among 3 Endocrine Axes In Nonmammalian Vertebratesmentioning

confidence: 99%

Knotting nets: Molecular junctions of interconnecting endocrine axes identified by application of the adverse outcome pathway concept

Brüggemann

Licht

Fetter

et al. 2017

Enviro Toxic and Chemistry

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To be defined as an endocrine disruptor, a substance has to meet several criteria, including the induction of specific adverse effects, a specific endocrine mode of action, and a plausible link between both. The latter criterion in particular might not always be unequivocally determined, especially because the endocrine system consists of diverse endocrine axes. The axes closely interact with each other, and manipulation of one triggers effects on the other. The present review aimed to identify some of the many interconnections between these axes. The focus was on fish, but data obtained in studies on amphibians and mammals were considered if they assisted in closing data gaps, because most of the endocrine mechanisms are evolutionarily conserved. The review includes data both from ecotoxicological studies and on physiological processes and gives information on hormone/hormone receptor interactions or gene transcription regulation. The key events and key event relationships identified provide explanations for unexpected effects on one axis, exerted by substances suspected to act specifically on another axis. Based on these data, several adverse outcome pathway (AOP) segments are identified, describing connections between the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-thyroid (HPT) axes, the HPG and hypothalamic-pituitary-adrenal/interrenal (HPA/I) axes, and the HPT and HPA/I axes. Central key events identified across axes were altered aromatase activity as well as altered expression and function of the proteins 11b-hydroxysteroid dehydrogenase (11b-HSD) and steroidogenic acute regulatory (StAR) protein. Substance classes that act on more than one endocrine axis were, for example, goitrogens or aromatase inhibitors. Despite the wealth of information gathered, the present review only provides a few insights into the molecular nets of endocrine axes, demonstrating the complexity of their interconnections.

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Effects of thyroid endocrine manipulation on sex-related gene expression and population sex ratios in Zebrafish

Cited by 39 publications

References 55 publications

Stress and sex determination in fish: from brain to gonads

Stress and sex determination in fish: from brain to gonads

Thyroid hormone actions on male reproductive system of teleost fish

Knotting nets: Molecular junctions of interconnecting endocrine axes identified by application of the adverse outcome pathway concept

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