Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying

Mano, Fumika; Ikeda, Kaori; Joo, Erina; Yamane, Shunsuke; Harada, Norio; Inagaki, Nobuya

doi:10.1016/j.nut.2017.08.007

Cited by 12 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are consistent with our previous findings that levels of three amino acids (histidine, glutamate, and aspartate) and sodium chloride corresponding to those found in Japanese broth promote gastric emptying (28). Promoted gastric emptying is a possible mechanism for less reflux and less dyspepsia.…”

Section: Discussionsupporting

confidence: 93%

“…But, there is no study to focus on the relationship between frequency of miso soup intake and frequency of epigastric symptoms. In our previous study, we found that levels of three amino acids (histidine, glutamate, and aspartate) and sodium chloride that closely parallel those in Japanese broth promote gastric emptying (23). We hypothesized that higher consumption of miso soup would be associated with a lower frequency of reflux or dyspepsia symptoms.…”

mentioning

confidence: 92%

“…A bowl of miso soup usually contains a tablespoon of miso paste that has about 32 kcal of energy, 2.1 g of protein, 1.1 g of fat, and 3.5 g of carbohydrate (http://www.mext.go.jp/en/policy/science_technology/ policy/title01/detail01/1374030.htm), and the salt content of miso soup is 0.5-1.2% (22). Japanese broth contains amino acids, but has virtually no calories (23). The nutrients contained in miso soup can differ between the ingredients used; basically, however, miso soup has low fat and low energy.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with <i>Miso</i> Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study

Mano

Ikeda

Sato

et al. 2018

Journal of Nutritional Science and Vitaminology

Self Cite

View full text Add to dashboard Cite

Dietary habits and lifestyles are considered to affect the frequency of epigastric symptoms. In our previous study, we found that three amino acids in Japanese broth promoted gastric emptying. We hypothesized that a higher consumption of miso soup which was mainly composed of Japanese broth and miso paste would be associated with a lower frequency of epigastric symptoms. We conducted a cross-sectional study of the association between frequency of miso soup intake and reflux or dyspepsia symptoms in a general Japanese population. Sixteen items of dietary habits were assessed using a self-reported questionnaire, and epigastric symptoms were evaluated using the Frequency Scale for Symptoms of Gastroesophageal Reflux Disease (FSSG). We fitted generalized linear models to analyze the association between miso soup intake and FSSG, reflux, or dyspepsia scores adjusted by age, sex, body mass index (BMI), another 15 dietary habits, smoking, drinking alcohol, and unfavorable dietary behaviors. A total of 9,364 subjects were included in the analysis. Trend analysis revealed that higher frequency of miso soup intake was associated with lower FSSG scores (p,0.001). In a generalized linear model, daily intake of miso soup was associated with lower FSSG, reflux, and dyspepsia scores independent of age, sex, BMI, other 15 dietary habits, smoking, drinking alcohol, and unfavorable dietary behaviors (estimate520.

show abstract

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 92%

mentioning

confidence: 99%

See 1 more Smart Citation

Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with <i>Miso</i> Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study

Mano

Ikeda

Sato

et al. 2018

Journal of Nutritional Science and Vitaminology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In contrast with whole-structure proteins, intragastric administration of isolated amino acids such as lysine, leucine, or isoleucine does not seem to influence gastric emptying, even though it may reduce postprandial glycemic levels, most probably by direct stimulation of insulin secretion [ 69 , 70 ]. However, paradoxical results are also published, leaving the debate about free amino acid effects on gastric emptying still open [ 71 , 72 ]. Other three amino acids, histidine, glutamate, and aspartate, were reported to increase both postprandial glycemic levels, velocity of gastric emptying, and GLP-1 serum concentrations [ 71 ].…”

Section: Influence Of Nutrients On Gastric Emptying and Glycemic Lmentioning

confidence: 99%

Bidirectional Relationship between Gastric Emptying and Plasma Glucose Control in Normoglycemic Individuals and Diabetic Patients

Mihai

Craiu

Cijevschi-Prelipcean

et al. 2018

Journal of Diabetes Research

View full text Add to dashboard Cite

Gastric emptying and glycemic control pathways are closely interrelated processes. Gastric chyme is transferred into the duodenum with velocities depending on its solid or liquid state, as well as on its caloric and nutritional composition. Once nutrients enter the intestine, the secretion of incretins (hormonal products of intestinal cells) is stimulated. Among incretins, glucagon-like peptide-1 (GLP-1) has multiple glycemic-regulatory effects that include delayed gastric emptying, thus triggering a feedback loop lowering postprandial serum glucose levels. Glycemic values also influence gastric emptying; hyperglycemia slows it down, and hypoglycemia accelerates it, both limiting glycemic fluctuations. Disordered gastric emptying in diabetes mellitus is understood today as a complex pathophysiological condition, with both irreversible and reversible components and high intra- and interindividual variability of time span and clinical features. While limited delays may be useful for reducing postprandial hyperglycemias, severely hindered gastric emptying may be associated with higher glycemic variability and worsened long-term glycemic control. Therapeutic approaches for both gastric emptying and glycemic control include dietary modifications of meal structure or content and drugs acting as GLP-1 receptor agonists. In the foreseeable future, we will probably witness a wider range of dietary interventions and more incretin-based medications used for restoring both gastric emptying and glycemic levels to nearly physiological levels.

show abstract

“…In healthy controls, elevated GLP-1 plasma levels after administration of the Dipeptidyl peptidase-4 inhibitor vildagliptin, were associated with impaired gastric accommodation (72). In Japan, gastric emptying was measured in healthy subjects and increased significantly after ingestion of a broth with rice, which was accompanied by a significantly more rapid rise in plasma GLP-1 and glucose levels compared to rice with water (73). In an earlier study, it was shown that GLP-1 was correlated with nausea in a single meal experiment in FD patients subtype EPS as well as in healthy volunteers (74).…”

Section: Glucagon-like Peptide 1 (Glp-1)mentioning

confidence: 99%

The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review

et al. 2020

View full text Add to dashboard Cite

Functional dyspepsia (FD) and gastroparesis (GP) are common disorders of the upper gastrointestinal tract. The pathophysiology of these conditions is likely to be heterogenous, and factors such as altered motility, sensitivity and response to nutrition have been identified as putative underlying mechanisms. Motility, sensitivity as well as responses to nutrition can be influenced or mediated by peptide hormones and serotonin released from the gastrointestinal mucosa. This review summarizes the role of GI peptides in functional dyspepsia and gastroparesis. In most studies, the levels of somatostatin, ghrelin, and motilin did not differ between healthy volunteers and FD or GP patients, but higher symptom burden was often correlated with higher peptide levels. Ghrelin and motilin receptor agonists showed promising results in improvement of the gastric emptying, but the link with improvement of symptoms is less predictable. Serotonin agonists have a potential to improve symptoms in both FD and idiopathic gastroparesis. Drugs acting on the GLP-1 and on the PYY receptors deserve further investigation. There is a need for systematic large scale studies.

show abstract

Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying

Cited by 12 publications

References 30 publications

Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with <i>Miso</i> Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study

Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with <i>Miso</i> Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study

Bidirectional Relationship between Gastric Emptying and Plasma Glucose Control in Normoglycemic Individuals and Diabetic Patients

The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review

Contact Info

Product

Resources

About