Effects of three-dimensional conformal radiotherapy on the esophageal carcinoma

Ma, Hongbing; Zhang, Xiaozhi; Wang, Xijing; Du, Min; Zhao, Xinhan

doi:10.1007/s10330-010-0643-0

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…In this study, the curative and side effects of chemoradiotherapy on EC among three major nationalities in Xinjiang (Han, Uigur and Kazakh, respectively) were compared and analyzed. The results showed that there were no significant differences in the short-term curative effects among the three groups, but there were significant differences in the long-term curative effects (even though the results of the long-term curative effects of the Han patients were a little different from those in another report, in which the reported 1-and 3-year survival rates after threedimensional conformal radiotherapy were 73.6% and 50.9% (Ma et al, 2010). The lower long-term survival rates among the Uigur and Kazakh patients compared to the Hans may be caused by the following reasons, a larger proportion of the Han patients who received radical operation and concurrent chemoradiotherapy, a poorer treatment compliance from the minority patients due to such factors as ethnic customs, religious beliefs, economic conditions, etc., and the potential molecular markers for prediction of the curative effects which may be different from nationality to nationality.…”

Section: Discussionmentioning

confidence: 59%

Comparisons of Curative and Side Effects of Chemoradiotherapy among Xinjiang Han, Uigur and Kazakh Esophageal Carcinoma Patients

Zhang

Ma²,

Yang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: This study aimed to explore the differences in the curative and side effects of chemoradiotherapy on esophageal cancer (EC) among Xinjiang Han, Uigur and Kazakh patients. Methods: 170 patients with IIA stage-IV of esophageal squamous cell carcinoma were analyzed retrospectively. Based on different nationalities, they were divided into the Han, Uigur and Kazakh groups. The 1-, 2-and 3-year survival rates, incidence of the side effects (including hematological toxicities, radioactive esophagitis and percutaneous reactions) and application of antibiotics and harmonics were compared among the groups. There was no significant difference in the short-term curative effects among the Han, Uigur and Kazakh groups. The 1-2-and 3-year survival rates of the three groups were 84%, 40%, 26%; 78%, 27%, 18%; and 60%, 21%, 12% (x 2 =14.497, P<0.05). The incidence rate of hamatological toxicity ≥Grade 2 in the Kazakh group was significantly lower than that in the Han or Uigur group. Results: The incidence rates of radioactive esophagitis and percutaneous reactions Grade 2 in the Han group were significantly higher than those in the Uigur or Kazakh group. There was no significant difference in the types of applied antibiotics among the groups, but there were significant differences in the days of antibiotic application and proportion of patients receiving harmonics between the Hans and either of other groups. Conclusion: Chemoradiotherapy shows a better effect in the long-term survival rate among Han EC patients compared with Uigur or Kazakh EC patients. Uigur and Kazakh patients show a better tolerance to the side effects of chemoradiotherapy compared with Hans.

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Section: Discussionmentioning

confidence: 59%

Comparisons of Curative and Side Effects of Chemoradiotherapy among Xinjiang Han, Uigur and Kazakh Esophageal Carcinoma Patients

Zhang

Ma²,

Yang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Upon checking the eligibility criteria, 169 RCTs remained for assessing the risk of bias. Among these papers, 17 RCTs reported the local recurrence of esophageal cell carcinoma 10,[12][13][14][26][27][28][29][30][31][32][33][34][35][36][37][38] and 152 RCTs reported other interesting outcomes in our comprehensive systematic review, the results of which will be published in the future. In this paper, we only included RCTs that had reported local recurrence (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…8,9 The most common type of recurrence reported in randomized controlled trials (RCTs) is the local (or loco-regional) type. The incidence of local recurrence is different following therapeutic interventions in published RCTs [10][11][12][13][14] and there is no single consensus on which therapeutic regimens have lower incidences of local recurrence. A network meta-analysis with simultaneous comparing of all available treatments is a useful tool in the selection of better treatments, 15 and producing the highest level of evidence in the ranking of treatments and clinical guidelines.…”

Section: Introductionmentioning

confidence: 99%

Local recurrence of esophageal squamous cell carcinoma after treatment: Comparison of frequentist and Bayesian network meta-analysis

Doosti-Irani

Mansournia

Rahimiforoushani

et al. 2019

Clinical Epidemiology and Global Health

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Background: We aimed to compare the treatments of esophageal cancer in association with the risk of disease recurrence, and to compare the frequentist and Bayesian methods in data analysis. Methods: Web of Science, Medline, Scopus, the Cochrane Library and EMBASE were searched. We assessed statistical heterogeneity, and the assumption of consistency was assessed using loop-specific and design-bytreatment interaction methods. The Markov chain Monte Carlo method was used to obtain the pooled estimates of effect size in the Bayesian approach. The random effect model was used to report the pooled Risk Ratios (RR). The results of this study were reported with 95% Confidence Interval (CI), and Credible interval (CrI). Results: We included 17 randomized controlled trials (RCTs) that reported the local recurrence of esophageal cancer. The RR of local recurrence for surgery plus paclitaxel, cisplatin, and radiotherapy (SPCRT) compared to surgery alone was 0.42 (95% CI: 0.21, 0.88). The RR for SPCRT compared with surgery plus cisplatin and vindesine (SCV) was 0.38 (95% CI: 0.12, 1.18). Compared to cisplatin, fluorouracil, and radiotherapy plus surgery (CFRTS), SPCRT was a better treatment (RR = 0.46, 95% CI: 0.17, 1.24). Conclusions: This network meta-analysis indicated that SPCRT compared to surgery alone and other treatments was a better treatment. In terms of ranking, SPCRT and radiotherapy plus surgery (RTS) were the first and second treatments in the network. It seems the precision of frequentist is better than Bayesian approach, however, the results of the ranking of treatments were same in both frequentist and Bayesian approaches.

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The DNA injury-repair of esophageal cancer EC109 cells to diallyl trisulfide (DATS) combining radiation

Zhang

2012

Chin. -Ger. J. Clin. Oncol.

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Effects of three-dimensional conformal radiotherapy on the esophageal carcinoma

Cited by 5 publications

References 8 publications

Comparisons of Curative and Side Effects of Chemoradiotherapy among Xinjiang Han, Uigur and Kazakh Esophageal Carcinoma Patients

Comparisons of Curative and Side Effects of Chemoradiotherapy among Xinjiang Han, Uigur and Kazakh Esophageal Carcinoma Patients

Local recurrence of esophageal squamous cell carcinoma after treatment: Comparison of frequentist and Bayesian network meta-analysis

The DNA injury-repair of esophageal cancer EC109 cells to diallyl trisulfide (DATS) combining radiation

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