Effects of Three Different Iron Supplementations in Term Healthy Infants after 5 Months of Life

Abstract

The aim of this study was to investigate the effects of different doses of iron on haematological status of breastfed infants. One hundred and thirteen infants were randomized into four groups at 5 months of age. Iron supplementation was given at doses of 1 mg/kg/day, 2 mg/kg/day, and 2 mg/kg/every other day in the first three study groups, respectively, and the last group received placebo. The hematological values, except hemoglobin, were higher in the group supplemented with iron at a dose of 2 mg/kg/day, and ferritin values were statistically higher in the group supplemented with iron at a dose of 2 mg/kg/every other day than in the group supplemented with iron at a dose of 1 mg/kg/day. We suggest that intermittent iron supplementation is more effective than a daily regimen in equal dosages.

Impact of Text Message Reminders on Caregivers’ Adherence to a Home Fortification Program Against Child Anemia in Rural Western China: A Cluster-Randomized Controlled Trial

“…36 The power to detect a difference in anemia rates between the treatment and control groups in a cluster RCT depends on 5 factors: On the basis of previous studies, [37][38][39][40] we assumed an intracluster correlation of 0.1 and an R 2 of 0.5. We then assumed 4 infants per village.…”

The Effect of Low Dose Iron and Zinc Intake on Child Micronutrient Status and Development during the First 1000 Days of Life: A Systematic Review and Meta-Analysis

“…Effect on hemoglobin concentration: We identified 30 RCTs [26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55], contributing 43 comparisons, for evaluating the effect of up to 15 mg of additional iron daily on hemoglobin levels of children 6–23 months of age. In total, 6569 children contributed to the pooled estimate.…”

“…Sub-group analyses of the 21 RCTs [26,27,28,31,32,33,34,36,37,38,40,42,44,45,48,49,50,51,52,53,54] reporting on the effect of iron interventions on serum ferritin indicated that iron has the strongest beneficial effect when it is the sole micronutrient administered (mean increase of 26.1 µg/L) and that it has a smaller, albeit significant, effect on serum ferritin when it is administered in combination with zinc (Figure 1). …”

Daily and every other day use of iron prophylaxis in the first year of life

“…Bu olumsuz etkilerden korunmak için 4 ay-1 yafl aras› bebeklere koruyucu dozda demir verilmesi gerekti¤i önerilmektedir (5). Bu dönemde koruyucu demir genelde günlük uygulanmakla beraber, günafl›r› veya haftal›k verilmesi ile ilgili literatürde az say›da çal›flma vard›r (6)(7)(8)(9)(10)(11)(12).…”

“…Demir eksikli¤i anemisi tedavisinde haftal›k tedavi yönte-minin baz› hematolojik de¤iflkenler üzerine daha etkili oldu¤u saptanm›flt›r. Ancak koruyucu demir verilmesinin gün afl›r› veya haftal›k verilmesiyle ilgili az say›da ve s›n›rl› say›da bebekle çal›flmalar bulunmaktad›r (6)(7)(8)(9)(10)(11)(12). Bizim yapt›¤›m›z çal›flma günlük koruyucu doz verilmesi yerine gün afl›r› koruma da verilebilece¤i tezini desteklemektedir.…”