Effects of Thoracic Epidural Anesthesia on Liver Blood Flow and Indocyanine Green Clearance Test in Living-Donor Liver Transplantation: A Prospective, Randomized, Double-Blind Study

Sayan, H.; Aydoğan, Mustafa Said; Bıçakcıoğlu, Murat; Toprak, Hüseyin; Işık, Burak; Yilmaz, Sezai

doi:10.1016/j.transproceed.2015.04.033

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…The ICG clearance assay is most commonly used to evaluate liver function (LF). The rate of ICG clearance is positively correlated with the effective blood flow in liver 31 32 33 . After ICG is intravenously injected into the body, it can immediately bind to plasma proteins and is therefore rapidly distributed throughout the body in the blood circulation and is specifically taken up by liver cells.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods

Zhang

Song

et al. 2016

Sci Rep

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Imaging methods to evaluate hepatic microcirculation (HM) and liver function (LF) by directly monitoring overall liver tissue remain lacking. This study establish imaging methods for LF that combines Laser speckle perfusion imaging (LSPI) and in vivo optical imaging (IVOI) technologies to investigate changes of hepatic microcirculation and reserve function in the animals gavaged with 50% ethanol (15 ml/kg·bw) for a model of acute alcoholic liver injury (ALI), and for evaluation of electroacupuncture (EA) effect. The liver blood perfusion and indocyanine green (ICG) distribution were observe by LSPI and IVOI separately. After EA, the livers were collected to measure the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), thromboxane A (TXA2), prostacyclin (PGI2) and endothelin (ET). The acquisitions of newly established LSPI of liver and ICG in vivo fluorescence imaging (ICG-IVFI), combining the results of other indexes showed: hepatic microcirculation perfusion (HMP) significantly reduced, ICG metabolism reduced, and ALT/AST increased in animal model with acute ALI. EA can reverse these changes. The use of LSPI of liver and ICG-IVFI, which was novel imaging methods for LF established in this study, could display the LF characteristics of ALI and the EA efficacy.

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Section: Discussionmentioning

confidence: 99%

Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods

Zhang

Song

et al. 2016

Sci Rep

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“…EA, as a local anesthesia method, achieves anesthesia by injecting analgesics into the epidural space to block sensory nerves [ 13 ]. Such anesthesia not only induces vasodilation in the occluded area to increase blood flow but also preserves the patient's consciousness and provides pain relief [ 14 , 15 ]. In the study of Zhu et al [ 16 ], it was pointed out that EA significantly improved the CF of postoperative esophageal cancer patients than GA. Hafezi et al [ 17 ] also reported that EA used in plastic surgery has a preventive effect on DVT.…”

Section: Introductionmentioning

confidence: 99%

Epidural Anesthesia versus General Anesthesia for Total Knee Arthroplasty: Influences on Perioperative Cognitive Function and Deep Vein Thrombosis

Ma¹,

Li²,

Zhang³

et al. 2022

Computational and Mathematical Methods in Medicine

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Purpose. This research mainly discussed the impacts of epidural anesthesia (EA) and general anesthesia (GA) on perioperative cognitive function (CF) and deep vein thrombosis (DVT) in patients undergoing total knee arthroplasty (TKA). Methods. One hundred and twenty-four patients undergoing TKA in our hospital between July 2015 and October 2021 were selected, of which 74 patients received EA (research group) and the other 50 patients received GA (control group). Perioperative CF, DVT, stress response indicators (norepinephrine, NE; cortisol, Cor), and heart rate (HR) levels were observed and compared. Risk factors affecting DVT of TKA patients were analyzed by logistic regression. Results. The research group had statistically better CF than the control group, with notably lower NE, Cor, and HR levels and incidence of DVT. Logistic regression analysis showed that the type of anesthesia and MoCA were risk factors for DVT in TKA patients. Conclusion. EA is more feasible for patients undergoing TKA, which is conducive to improving their CF, relieving stress responses, and reducing the incidence of DVT, with a certain sedative effect.

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“…Epidural anesthesia reversibly blocks the sensory nerves through the administration of an analgesic agent into the epidural space. Local anesthesia blocks not only the sensory nerves but also the sympathetic neurotransmission, leading to vasodilation in the blocked region, thereby increasing the blood flow [28]. To perform a nerve block of the spinal segment that dominates the liver in dogs, a block of the first lumbar vertebrae (L1) from the twelfth thoracic vertebrae (T12) is necessary [30].…”

Section: Introductionmentioning

confidence: 99%

“…Hepatic blood flow is affected by the circulation's general dynamics. General anesthesia and epidural anesthesia may inhibit the circulatory dynamics and possibly cancel the effect of increased blood flow to the organs when the sympathetic nerves are inhibited by epidural anesthesia [28]. To maintain the systemic arterial blood pressure (BP), we decided to use total intravenous anesthesia (TIVA), which has a relatively mild circulatory inhibitory effect compared to inhaled anesthetics [13,14].…”

Section: Introductionmentioning

confidence: 99%

Effects of thoracolumbar epidural anesthesia with lidocaine on the systemic hemodynamics and hepatic blood flow in propofol anesthetized dogs

Iseri

Nakamori²,

Fujimoto

2021

The Journal of Veterinary Medical Science

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General anesthesia reduces hepatic blood flow (HBF) from circulatory depression. Total intravenous anesthesia (TIVA) is associated with decreased circulatory depression compared to inhalation anesthesia, and epidural anesthesia using local anesthetics increases blood flow by blocking the sympathetic nerves and expanding blood vessels. We investigated the effects of thoracolumbar epidural anesthesia with TIVA on HBF in dogs. Six Beagle dogs had epidural catheters placed between T13 and L1 and were anesthetized with propofol and vecuronium. Physiological saline (control) or 2% lidocaine (0.2 ml/kg, followed by 0.2 ml/kg/hr) was administered at 1-2 weeks intervals. Heart rate (HR), cardiac index (CI), mean arterial pressure (MAP), and systemic vascular resistance index (SVRI) were recorded at 10-min intervals from before epidural injections (T0) to 110 min. Indocyanine green test was used to measure HBF during the awake state and until 90 min after epidural injections. HR and CI did not differ between treatments. MAP and SVRI after lidocaine were significantly lower than those of controls, and the lowest MAP value was 65±11 mmHg at T10. Compared to T0, after lidocaine treatment, HBF was significantly higher at T30, T60 and T90 (p<0.05); while, after control treatment, no significant change was evident at any time point. Despite a decrease in MAP by this technique, HBF was either maintained at pre-anesthetic levels or increased in comparison to controls, probably due to vasodilation of the hepatic artery induced by the selective blockade sympathetic ganglia.

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Effects of Thoracic Epidural Anesthesia on Liver Blood Flow and Indocyanine Green Clearance Test in Living-Donor Liver Transplantation: A Prospective, Randomized, Double-Blind Study

Cited by 7 publications

References 12 publications

Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods

Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods

Epidural Anesthesia versus General Anesthesia for Total Knee Arthroplasty: Influences on Perioperative Cognitive Function and Deep Vein Thrombosis

Effects of thoracolumbar epidural anesthesia with lidocaine on the systemic hemodynamics and hepatic blood flow in propofol anesthetized dogs

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