Effects of Thiopental, Propofol, Etomidate, Midazolam on Hemodynamic in Anesthesia Induction and Intubation of Hypertensive Patients in the Coronary Artery Bypass Grafting Surgery

Abstract

Objective: The purpose of this study is to compare the hemodynamic effects of thiopental, propofol, etomidate, midazolam on induction of anesthesia, laryngoscopy, and endotracheal intubation of hypertensive patients who will undergo coronary artery bypass grafting (CABG) surgery. Material and Methods: A total of 80 patients with chronic hypertension, aged between 40 and 75 who are to undergo CABG surgery were included in a prospective, single-blind, and randomized study. Group T received thiopental sodium (5-7 mg kg-1), Group E etomidate (0.2-0.5 mg kg-1), Group P propofol (1-2.5 mg kg-1), and Group M midazolam (0.1-0.4 mg kg-1) anesthetic agents. The induction was achieved by using fentanyl and rocuronium in all groups. Heart rate (HR), systolic arterial pressure (SAP),diastolic arterial pressure (DAP), mean arterial pressure (MAP) were recorded for the first 15 minutes. Also arterial blood gases (ABG) were sampled, and partial arterial carbon dioxide (aCO 2) values were recorded.