Effects of thiopental in cold ischemia in liver transplantation: An experimental study

Bűyűk, Başak; Karakoç, Ebru

doi:10.28982/josam.460075

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…In addition, TUNEL method is used alone and effectively in many experimental study models other than the UUO model. In our study, the clarity of the data supports this [41,42].…”

Section: Discussionsupporting

confidence: 84%

Analysis of apoptosis of kidney tissue by the tunel method and histomorphological changes in rabbit kidney model due to unilateral supravesical obstruction

Uçak¹,

Topçu²,

Sarı³

2020

Journal of Surgery and Medicine

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“…In addition, TUNEL method is used alone and effectively in many experimental study models other than the UUO model. In our study, the clarity of the data supports this [41,42].…”

Section: Discussionsupporting

confidence: 84%

Analysis of apoptosis of kidney tissue by the tunel method and histomorphological changes in rabbit kidney model due to unilateral supravesical obstruction

Uçak¹,

Topçu²,

Sarı³

2020

Journal of Surgery and Medicine

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“…The surgical model used in the experiment was performed as previously described in the literature 2 , 22 . The rats were anesthetized with ketamine hydrochloride (50 mg/kg, Ketalar ® , Pfizer, Turkey) and Xylazine (10 mg/kg, Rompun ® , Bayer, Canada).…”

Section: Methodsmentioning

confidence: 99%

A new organ preservation solution for static cold storage of the liver. Amniotic fluid

et al. 2019

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Purpose: To evaluate the effect of amniotic fluid in liver preservation in organ transplantation, and compare it with standard preservation solutions. Methods: The groups consisted of Group 1: Ringer Lactate (RL) group, Group 2: HTK group, Group 3: UW group, Group 4: AF group. The livers of rats from Group 1, 2, 3, and 4 were perfused and placed into falcon tubes containing RL, HTK, UW, and AF solutions at +4‎°C, respectively. The tubes were stored for 12 hours in the refrigerator at +4°C. Tissue samples were taken at the 6 th and 12 th hours for histopathological examinations of the perfused livers, and storage solutions for biochemical analyzes at 6 th and 12 th hours. Results: AF was shown to maintain organ viability by reducing the number of cells undergoing apoptosis. Histopathological changes such as sinusoidal dilatation, hydropic degeneration, and focal necrosis were found to be similar to the groups in which the standard organ preservation solutions were used. Additionally, the results of INOS, IL-10, and TNF-α,which were evaluated immunohistochemically, have been shown to be similar to the UW and HTK groups. Conclusions: AF provided conservation similar to UW and HTK in the 12-hour liver SCS process. The fact that apoptosis values are comparable to standard preservation solutions supports the success of AF in the cold storage of the liver.

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“…Thiopental is an effective anticonvulsant that decreases oxygen consumption of the brain (Büyük and Karakoç 2019). Both agents reduce cerebral blood ow and metabolic rate.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Cerebral Effects of Thiopental and Propofol Infusion in Traumatic Brain Injured Rats

Yıldız¹,

Kiliccioglu²,

Yoldaş³

et al. 2021

Preprint

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Objective: To compare the cerebral effects of propofol and thiopental infusions in rats with experimental head trauma.Methods: This experimental study included a total of 30 rats, and the animals were randomly divided into 3 groups; as control group (Group C), propofol group (Group P) and thiopental group (Group T). Blood samples were taken 4 hours following infusion. A craniotomy was performed, the brain was removed, and it was placed in 10% neutral formalin for histopathological examination. The materials were examined biochemically and histopathologically, and then compared between the groups.Results: The S100B value between the groups was significantly lower in the thiopental group compared to the control group (p = 0.018). Tau protein levels were significantly lower in the propofol group compared to the control group (p = 0.07).In histological examinations, the numbers of apoptotic cells in the propofol and thiopental groups were significantly lower than in the control group (p = 0.02). There was no significant difference between the propofol and thiopental groups in terms of apoptotic cell numbers (p = 0.3). Conclusion: Our study demonstrated that thiopental and propofol infusions following a head trauma reduce apoptotic cell death and cause decreases in trauma markers.

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Effects of thiopental in cold ischemia in liver transplantation: An experimental study

Cited by 4 publications

References 32 publications

Analysis of apoptosis of kidney tissue by the tunel method and histomorphological changes in rabbit kidney model due to unilateral supravesical obstruction

Analysis of apoptosis of kidney tissue by the tunel method and histomorphological changes in rabbit kidney model due to unilateral supravesical obstruction

A new organ preservation solution for static cold storage of the liver. Amniotic fluid

Comparison of Cerebral Effects of Thiopental and Propofol Infusion in Traumatic Brain Injured Rats

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