Effects of theta burst stimulation on glutamate levels in a patient with negative symptoms of schizophrenia

Bor, Julie; Brunelin, Jérôme; Rivet, Adrien; d’Amato, Thierry; Poulet, Emmanuel; Saoud, Mohamed; Padberg, Frank

doi:10.1016/j.schres.2009.03.012

Cited by 22 publications

(11 citation statements)

References 8 publications

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“…Theta burst stimulation (TBS) is a relatively new rTMS protocol that modulates activity in the underlying region in a shorter period of time, enabling more potent and longer-lasting post stimulation effects compared with standard rTMS (Huang et al, 2005; Stefan et al, 2008). Consecutive sessions of TBS have been employed safely and with promising clinical efficacy in schizophrenia (Bor et al, 2009; Sidhoumi et al, 2010), levodopa induced dyskinesias (Koch et al, 2009), spasticity (Mori et al, 2010) and depression (Chistyakov et al, 2010). Notably, ten sessions of standard TBS to lateral cerebellar hemispheres have led to improvement in levodopa-induced dyskinesias, highlighting the capability of TBS to augment long lasting plasticity via modulation of the cerebello-thalamo-cortical circuits (Koch et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophrenia

Demirtaş-Tatlıdede¹,

Freitas²,

Cromer³

et al. 2010

Schizophrenia Research

152

110

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BACKGROUND Early invasive electrical stimulation studies suggested that enhancement of cerebellar vermal activity might prove valuable in symptomatic treatment of refractory neuropsychiatric diseases via modulation of emotion and affect. This proof of principle study aimed to test this hypothesis using noninvasive brain stimulation, and to explore the safety of this protocol in schizophrenia. METHODS Eight treatment-refractory patients with schizophrenia underwent ten sessions of intermittent theta burst stimulation (TBS) to the cerebellar vermis using MRI-guided transcranial magnetic stimulation (TMS). Assessments included side effect questionnaires, cardiovascular monitoring, psychiatric evaluations and comprehensive neuropsychological testing before and after TBS and at one-week follow-up. RESULTS Overall, TBS was tolerated well with mild side effects primarily comprising neck pain and headache. No serious adverse events occurred. Diastolic blood pressure (BP) showed mild decreases for five minutes post-TBS; no significant changes were detected for systolic BP or pulse. PANSS negative subscale showed significant improvements following TBS and during the follow-up. Calgary Depression Scale and self-report visual analog scales for Happiness and Sadness pointed to significant mood elevation. Neuropsychological testing revealed significantly fewer omissions in working memory and interference conditions of a Continuous Performance Test, a longer spatial span and better delay organization on the Rey-Osterrieth Complex Figure during follow-up. No significant worsening in psychiatric or neuropsychological measures was detected. CONCLUSIONS Theta burst stimulation of the cerebellar vermis is safe and well-tolerated, while offering the potential to modulate affect, emotion and cognition in schizophrenia. Future randomized, sham-stimulation controlled studies are warranted to support the clinical efficacy of this technique.

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Section: Introductionmentioning

confidence: 99%

Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophrenia

Demirtaş-Tatlıdede¹,

Freitas²,

Cromer³

et al. 2010

Schizophrenia Research

152

110

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“…Antipsychotic medication regulates HPA axis activity, whereas agents that release cortisol exacerbate psychotic symptoms [8]. In line with this, rTMS applied over the left DLPFC reducing negative symptoms of schizophrenia can modulate glutamate/GABA concentrations in the left DLPFC and hippocampus [23], as well as induce dopamine release in the ventral striatum [24].…”

Section: Modulation Of Neurotransmissionmentioning

confidence: 83%

Can the Effects of Noninvasive Brain Stimulation Alleviating Neuropsychiatric Symptoms Result From a Common Beneficial Regulation of the Hypothalamic-pituitary-adrenal Axis?

Fecteau¹

2015

Brain Stimulation

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“…Recent findings indicate that cTBS applied to the TPC reduces auditory verbal hallucinations [85,86]. For instance, a case report showed that left cTBS reduced long-term persistent auditory hallucinations, which was accompanied by overall improvement in neuropsychological performance [85].…”

Section: Schizophreniamentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation for Clinical Applications in Neurological and Psychiatric Disorders: An Overview

Machado¹,

Arias-Carrión

Paes

et al. 2013

EAJM

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Neurological and psychiatric disorders are characterized by several disabling symptoms for which effective, mechanism-based treatments remain elusive. Consequently, more advanced non-invasive therapeutic methods are required. A method that may modulate brain activity and be viable for use in clinical practice is repetitive transcranial magnetic stimulation (rTMS). It is a non-invasive procedure whereby a pulsed magnetic field stimulates electrical activity in the brain. Here, we focus on the basic foundation of rTMS, the main stimulation parametters, the factors that influence individual responses to rTMS and the experimental advances of rTMS that may become a viable clinical application to treat neurological and psychiatric disorders. The findings showed that rTMS can improve some symptoms associated with these conditions and might be useful for promoting cortical plasticity in patients with neurological and psychiatric disorders. However, these changes are transient and it is premature to propose these applications as realistic therapeutic options, even though the rTMS technique has been evidenced as a potential modulator of sensorimotor integration and neuroplasticity. Functional imaging of the region of interest could highlight the capacity of rTMS to bring about plastic changes of the cortical circuitry and hint at future novel clinical interventions. Thus, we recommend that further studies clearly determine the role of rTMS in the treatment of these conditions. Finally, we must remember that however exciting the neurobiological mechanisms might be, the clinical usefulness of rTMS will be determined by its ability to provide patients with neurological and psychiatric disorders with safe, long-lasting and substantial improvements in quality of life.

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Effects of theta burst stimulation on glutamate levels in a patient with negative symptoms of schizophrenia

Cited by 22 publications

References 8 publications

Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophrenia

Safety and proof of principle study of cerebellar vermal theta burst stimulation in refractory schizophrenia

Can the Effects of Noninvasive Brain Stimulation Alleviating Neuropsychiatric Symptoms Result From a Common Beneficial Regulation of the Hypothalamic-pituitary-adrenal Axis?

Repetitive Transcranial Magnetic Stimulation for Clinical Applications in Neurological and Psychiatric Disorders: An Overview

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