Effects of the WRITE Symptoms Interventions on Symptoms and Quality of Life Among Patients With Recurrent Ovarian Cancers: An NRG Oncology/GOG Study (GOG-0259)

Donovan, Heidi S.; Sereika, Susan M.; Wenzel, Lari; Edwards, Robert P.; Knapp, Judith E.; Hughes, Susan; Roberge, Mary; Thomas, Teresa Hagan; Klein, Sara; Spring, Michael B.; Nolte, Susan; Landrum, Lisa M.; Casey, Aggie; Mutch, David G.; Debernardo, Robert; Muller, Carolyn Y.; Sullivan, Stephanie A.; Ward, Sandra E.

doi:10.1200/jco.21.00656

Cited by 14 publications

(8 citation statements)

References 42 publications

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“…7 Emerging consensus on the efficacy of routine electronic symptom reporting and follow-up interventions could also strengthen symptom reduction in this population. 20,[51][52][53] The efficacy of weekly electronic PRO monitoring for adults with metastatic cancer receiving treatment (including symptoms with alerts to clinicians for severe or worsening symptoms) on improving symptoms has recently been reported. 54 A similar symptom-specific intervention that integrates GA could be evaluated for older patients with aging-related conditions.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Geriatric Assessment Intervention on Patient-Reported Symptomatic Toxicity in Older Adults With Advanced Cancer

Culakova

Mohile

Peppone

et al. 2023

JCO

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PURPOSE Providing a geriatric assessment (GA) summary with management recommendations to oncologists reduces clinician-rated toxicity in older patients with advanced cancer receiving treatment. This secondary analysis of a national cluster randomized clinical trial (ClinicalTrials.gov identifier: NCT02054741 ) aims to assess the effects of a GA intervention on symptomatic toxicity measured by Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE). METHODS From 2014 to 2019, the study enrolled patients age ≥ 70 years, with advanced solid tumors or lymphoma and ≥ 1 GA domain impairment, who were initiating a regimen with high prevalence of toxicity. Patients completed PRO-CTCAEs, including the severity of 24 symptoms (11 classified as core symptoms) at enrollment, 4-6 weeks, 3 months, and 6 months. Symptoms were scored as grade ≥ 2 (at least moderate) and grade ≥ 3 (severe/very severe). Symptomatic toxicity was determined by an increase in severity during treatment. A generalized estimating equation model was used to assess the effects of the GA intervention on symptomatic toxicity. RESULTS Mean age was 77 years (range, 70-96 years), 43% were female, and 88% were White, 59% had GI or lung cancers, and 27% received prior chemotherapy. In 706 patients who provided PRO-CTCAEs at baseline, 86.1% reported at least one moderate symptom and 49.7% reported severe/very severe symptoms at regimen initiation. In 623 patients with follow-up PRO-CTCAE data, compared with usual care, fewer patients in the GA intervention arm reported grade ≥ 2 symptomatic toxicity (overall: 88.9% v 94.8%, P = .035; core symptoms: 83.4% v 91.7%, P = .001). The results for grade ≥ 3 toxicity were comparable but not significant ( P > .05). CONCLUSION In the presence of a high baseline symptom burden, a GA intervention for older patients with advanced cancer reduces patient-reported symptomatic toxicity.

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Section: Discussionmentioning

confidence: 99%

Effects of a Geriatric Assessment Intervention on Patient-Reported Symptomatic Toxicity in Older Adults With Advanced Cancer

Culakova

Mohile

Peppone

et al. 2023

JCO

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“…For example, women with OvCa undergoing treatment suffer from 12 to 14 concurrent symptoms on average. 3 , 4 Women with OvCa are required to gain and learn extensive information to manage the condition, decide on treatment plans, and communicate with providers. Therefore, they may exhibit active information seeking behavior or passive information acquisition behavior.…”

Section: Background and Significancementioning

confidence: 99%

Women with ovarian cancer’s information seeking and avoidance behaviors: an interview study

Chi,

Hui,

Kunsak

et al. 2024

JAMIA Open

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Objectives Despite the importance of using information for ovarian cancer (OvCa) disease management and decision-making, some women with OvCa do not actively seek out information. The purpose of this study is to investigate factors that influence information seeking behaviors and information avoidance behaviors and information resources among women with OvCa and their caregivers. Materials and methods We conducted in-depth interviews with OvCa patients or caregivers of OvCa (n = 20) and employed deductive and inductive coding methodologies for analysis. Results Our analysis revealed 5 emerging themes associated with active information seeking behavior, 5 themes of passive information acquisition, and 4 themes of information avoidance behavior. Additionally, we identified participants’ preferred information sources for OvCa management, such as health organization or government operated resources and web-based social groups. Discussion To enhance information access, strategies should be developed to motivate people with OvCa to seek rather than avoid information. The study emphasizes the significance of promoting patient–provider communication and leveraging strong social support networks for effective information acquisition. Conclusion Our findings provide valuable implications for clinical practice and policymaking, emphasizing the need to improve access to information for individuals with OvCa. By addressing the identified factors influencing information seeking behaviors, healthcare professionals and policymakers can better support patients and caregivers in their information-seeking journey, ultimately enhancing disease management and decision-making outcomes.

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“…However, symptom burden and HRQL did not improve in either intervention-arm. 83 The authors suggested the lack of improvement in symptom burden might be due to the highly variable nature of symptoms in ROC. 83 Moreover, the authors acknowledged patients with high symptom burden had difficulty engaging in self-management interventions.…”

Section: Dovepressmentioning

confidence: 99%

“…83 The authors suggested the lack of improvement in symptom burden might be due to the highly variable nature of symptoms in ROC. 83 Moreover, the authors acknowledged patients with high symptom burden had difficulty engaging in self-management interventions. Given the high symptom burden of ROC, future research should extend these efforts and examine the use of novel PRO-based interventions to facilitate enhanced symptom management and potentially improve the HRQL of women with ROC.…”

Section: Dovepressmentioning

confidence: 99%

Patient-Reported Outcomes in Ovarian Cancer: Facilitating and Enhancing the Reporting of Symptoms, Adverse Events, and Subjective Benefit of Treatment in Clinical Trials and Clinical Practice

Campbell¹,

King²,

Stockler³

et al. 2023

PROM

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Patient-reported outcomes (PROs) provide a valid, standardized way of assessing symptoms, adverse events and the subjective benefit of treatment from the patient's perspective. Assessment of PROs is critical in ovarian cancer due to the high morbidity of the disease and its treatments. Several well-validated PRO measures are available to assess PROs in ovarian cancer. Their inclusion in clinical trials can provide evidence on the benefits and harms of new treatments based on patients' experiences to guide improvements in clinical practice and health policy. Aggregate PRO data collected in clinical trials can be used to inform patients about likely treatment impacts and assist them to make informed treatment decisions. In clinical practice, PRO assessments can facilitate monitoring of a patient's symptoms throughout treatment and follow-up to guide their clinical management; in this context, an individual patient's responses can facilitate communication with their treating clinician about troublesome symptoms and their impact on their quality of life. This literature review aimed to provide clinicians and researchers with a better understanding of why and how PROs can be incorporated into ovarian cancer clinical trials and routine clinical practice. We discuss the importance of assessing PROs throughout the ovarian cancer disease and treatment trajectory in both clinical trials and clinical practice, and provide examples from existing literature to illustrate the uses of PROs as the goals of treatment change in each setting.

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Effects of the WRITE Symptoms Interventions on Symptoms and Quality of Life Among Patients With Recurrent Ovarian Cancers: An NRG Oncology/GOG Study (GOG-0259)

Cited by 14 publications

References 42 publications

Effects of a Geriatric Assessment Intervention on Patient-Reported Symptomatic Toxicity in Older Adults With Advanced Cancer

Effects of a Geriatric Assessment Intervention on Patient-Reported Symptomatic Toxicity in Older Adults With Advanced Cancer

Women with ovarian cancer’s information seeking and avoidance behaviors: an interview study

Patient-Reported Outcomes in Ovarian Cancer: Facilitating and Enhancing the Reporting of Symptoms, Adverse Events, and Subjective Benefit of Treatment in Clinical Trials and Clinical Practice

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