Effects of the wetting liquid and ethylcellulose on the properties of atenolol-containing pellets

Hamedelniel, Elnazeer I.; Bajdik, János; Sovány, Tamás; Kása, P.; Pintye‐Hódi, Klára

doi:10.1016/s1773-2247(11)50022-x

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…Hamedelniel et al, studied and reported that the presence of ethanol in the wetting liquid led to a decrease in the liberation of the active agent in the first phase of the dissolution process with a reduction in the hardness of the pellets. The investigation also reveals that the plasticity of the mass can be varied by the type of the granulating liquid [53]. Recently, Gaith et al, studied the effect of aqueous and organic granulating fluid on the physical properties of the pellets.…”

Section: Granulating Liquidmentioning

confidence: 98%

An Outline of Variables in Pelletization by Extrusion and Spheronization

Mishra¹,

Paldewar²,

Nandgude³

2020

Int J App Pharm

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Pelletization is an agglomeration process which converts fine granules or powders of bulk drugs into small, free-flowing, spherical units, known as pellets. The pelletization can be achieved either through agitation, compaction (extrusion-spheronization), drug layering and globulation. Among the various pelletization techniques extrusion–spheronization process is preferred over other methods for the preparation of pellets as it allows the incorporation of the higher amount of drug, modified physical characteristics of the drug (density, sphericity, narrow size distribution, smoother surface) and multiple drugs can be easily combined in the same unit. This current review summarizes the findings or investigations by the researchers on various variables, including process parameters, equipment parameters and formulation parameters influencing the quality of pellets. The article also focuses on process optimization and additives used in pellets formulation. To prepare the current review search criterion used was the parameters affecting final pellet characterization in the extrusion spheronization process. The sources were peer-reviewed relevant scientific articles of recognized journals. Keywords used as filters were extrusion, spheronization, formulation parameters, process parameters, equipment parameters, moisture content, granulating liquid, drying rate, extrusion temperature, spheronizer load, pelletization. Literature survey has been done in a range of years (1992-2019) regarding the various variables of the extrusion spheronization process, which affects and has foremost impact on the final quality of pellets so as to make the review updated and comprehensive.

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Section: Granulating Liquidmentioning

confidence: 98%

An Outline of Variables in Pelletization by Extrusion and Spheronization

Mishra¹,

Paldewar²,

Nandgude³

2020

Int J App Pharm

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show abstract

“…When comparing the celestial mixture but also screw-based mixture, a mixture form (rather than even the shear force rate) does have the biggest effect upon that paste characteristics. while spheronized under same constraints, pellets created as for screw mixed material exhibit greater yield, strength, as well as produce smaller pellets with an increased size distribution [20][21][22].…”

Section: Mixermentioning

confidence: 99%

Test

2023

Fut J. Pharm & H. Sci

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“…The RRSBW model is generally utilized to describe the dissolution profile in the event of a sigmoid shape. Another model that can be used in this case is the ChapmanRichards model [48].…”

Section: Model-dependent Evaluation Of Dissolution Curvesmentioning

confidence: 99%

Development and characterization of modified-release oral preparations containing riboflavin

Buchholcz

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Effects of the wetting liquid and ethylcellulose on the properties of atenolol-containing pellets

Cited by 7 publications

References 25 publications

An Outline of Variables in Pelletization by Extrusion and Spheronization

An Outline of Variables in Pelletization by Extrusion and Spheronization

Test

Development and characterization of modified-release oral preparations containing riboflavin

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