Effects of the T-type calcium channel antagonist Z944 on paired associates learning and locomotor activity in rats treated with the NMDA receptor antagonist MK-801

Roebuck, Andrew J.; Marks, Wendie N.; Liu, Max C.; Tahir, Nimra B.; Zabder, Nadine K.; Snutch, Terrance P.; Howland, John G.

doi:10.1007/s00213-018-5040-3

Cited by 6 publications

(3 citation statements)

References 51 publications

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“…Therefore, the data from the current study suggests that Z944 may have antipsychotic properties. Indeed, both Z944 and the pan T-type calcium channel antagonist, TTA-A2, have previously been demonstrated to reduce amphetamine or MK-801 induced hyperlocomotion, an assay predictive of antipsychotic efficacy [45,46]. Further, many neuroleptic agents block T-type calcium channels suggesting that their therapeutic efficacy may be associated with their T-type calcium channel activity [47,48].…”

Section: The Effects Of Z944 On Social Interaction Behaviors In Gaers...mentioning

confidence: 99%

The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg

Marks

Zabder

Cain

et al. 2019

Behavioural Brain Research

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Section: The Effects Of Z944 On Social Interaction Behaviors In Gaers...mentioning

confidence: 99%

The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg

Marks

Zabder

Cain

et al. 2019

Behavioural Brain Research

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“…(3) Social withdrawal, which is an example of a negative symptom 11 . (4) Cognitive dysfunction in behavioral set‐shifting, 12 reversal learning, 13 and paired‐associate learning 14 …”

Section: Introductionmentioning

confidence: 99%

“… 11 (4) Cognitive dysfunction in behavioral set‐shifting, 12 reversal learning, 13 and paired‐associate learning. 14 …”

Section: Introductionmentioning

confidence: 99%

Pharmacologically induced N‐methyl‐D‐aspartate receptor hypofunction impairs goal‐directed food seeking in rats

Ozawa

Itokazu

Ichitani

et al. 2021

Neuropsychopharm Rep

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Aim Acute N‐methyl‐D‐aspartate (NMDA) receptor antagonism is an important pharmacological animal model of schizophrenia. In previous studies, schizophrenia patients show impaired goal‐directed behavior in an outcome‐specific devaluation procedure. In this study, we investigated whether the rat model of the NMDA receptor blockade also showed altered goal‐directed behavior in a satiety‐induced outcome devaluation paradigm. Methods In experiments 1 and 2, we aimed to establish the satiety‐induced outcome devaluation test using sucrose and lipid rewards in operant conditioning and free consumption paradigms. In experiment 3, we tested the effect of MK‐801 (0.1 mg/kg, i.p.) on outcome‐specific devaluation. Results Experiments 1 and 2 demonstrated that 1‐h ad libitum food consumption is sufficient to induce outcome‐specific devaluation in both lever‐press and free consumption tests in rats. Experiment 3 showed that the administration of MK‐801 impaired satiety‐induced devaluation in the lever‐press test but not in the subsequent free consumption test. Conclusions Our results suggest that acute pharmacological NMDA receptor antagonism in rats is a useful animal model for impaired goal‐directed behavior in schizophrenia.

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Pharmacology of Calcium Channel

Mallik

Acharya

2020

Frontiers in Pharmacology of Neurotransmitters

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Effects of the T-type calcium channel antagonist Z944 on paired associates learning and locomotor activity in rats treated with the NMDA receptor antagonist MK-801

Cited by 6 publications

References 51 publications

The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg

The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg

Pharmacologically induced N‐methyl‐D‐aspartate receptor hypofunction impairs goal‐directed food seeking in rats

Pharmacology of Calcium Channel

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