Effects of the Serotonin Precursor 5-Hydroxytryptophan and the Neurotoxic Analog 5,7-Dihydroxytryptamine on the Formation of a Conditioned Defensive Reflex in the Common Snail

Effects of Thryptophan Hydroxylase Blockade by P-Chlorophenylalanine on Contextual Memory Reconsolidation after Training of Different Intensity

“…A characteristic feature of mollusks is that their defensive reflexes are mediated by serotonin [1][2][3][4][5]8,10,85,107]. Thus, it was found that anxious-like behavior in crayfish is controlled by serotonin [108], and in the snail, the formation of long-term sensitization is blocked by the neurotoxin 5,6-dihydroxytryptamine [27,109,110]. This also applies to the conditioned reflex to the situation (context), the base for which is the serotonergic neurons of the pedal ganglion [11,65,107].…”

“…formation of long-term sensitization is blocked by the neurotoxin 5,6-dihydroxytryptamine [27,109,110]. This also applies to the conditioned reflex to the situation (context), the base for which is the serotonergic neurons of the pedal ganglion [11,65,107].…”

“…Previously we found that PCPA at doses mentioned above induced the impairment of the formation of defensive conditioning in terrestrial snails as neurotoxins 5,7-DHT and 5,6-DHT [3], which occurred in the condition of the serotonin depletion in the nerve system [1][2][3]7,27,28,77,114,115].…”

“…It was shown that electrophysiological correlates of plasticity can be reproduced by applying 5-HT applications to the solution surrounding the central nervous system of mollusks [13][14][15][16][17][18][19][20][21]. On the other hand, the neurotoxic analogues of serotonin 5,6-and 5,7-dihydroxytryptamine (5, leading to the depletion of serotonin is widely used to study the role of the serotoninergic system in the formation of behavior and learning [1,7,[22][23][24][25][26][27][28].…”