Effects of the ResQPod� on Maximum Concentration and Time to Maximum Concentration of Epinephrine in a Porcine Cardiac Arrest Model

Johnson, Don; Rushton, Jackie; Hern, Maxwell; ez,; Stone, Jessica; Brzuchalski, Jason; O’Sullivan, Ltc Joseph; Loughren, Ltc Michael

doi:10.4172/2324-903x.s1-002

Cited by 2 publications

(7 citation statements)

References 20 publications

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“…Tmax was longer when using ResQPod® compared to the control group. Although there were differences between the groups, the results were not statistically significant relative to Cmax and Tmax (p=0.276)" [28] . A graphical and table representation of this can be found further down in this section.…”

Section: Clinically Focusedmentioning

confidence: 83%

“…A graphical and table representation of this can be found further down in this section. The theoretical foundation of that study is that the time to maximum epinephrine concentration levels should be decreased in the ResQPOD group due to the increased venous return to the heart [28] . However, the results of this study and another study by Jenkins et al suggest that there is no significant difference between drug concentrations with and without use of the ResQPOD [28,29] .…”

Section: Clinically Focusedmentioning

confidence: 99%

“…The Tmax was greater in the group with the ResQPod when compared to the control group that did not utilise the ResQPod. Tmax was measured in minutes [28] . Cmax is measured in nanograms of epinephrine per milliliter (ng/mL) of plasma [28] .…”

Section: Clinically Focusedmentioning

confidence: 99%

“…Tmax was measured in minutes [28] . Cmax is measured in nanograms of epinephrine per milliliter (ng/mL) of plasma [28] .…”

Section: Clinically Focusedmentioning

confidence: 99%

“…The Tmax was greater in the group with the ResQPod when compared to the control group that did not utilise the ResQPod. Tmax was measured in minutes[28] .…”

mentioning

confidence: 99%

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The ResQCPR System: An Objective and Systematic Review

Goodwin

Zeid

Belok

2021

ijirms

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The resource-limiting environment of the pre-hospital setting necessitates the continuous development of tools and interventions that maximise the capabilities of emergency medical services (EMS) municipalities. One such product developed by Zoll, the ResQCPR system, attempts to enhance the effectiveness of prehospital cardiopulmonary resuscitation (CPR). The ResQCPR system is comprised of the ResQPOD, which is an impedance threshold device (ITD), and the ResQPUMP, which is an assisted compression-decompression (ACD) device. Limited data exists regarding Zoll’s specific apparatuses as well as similar such devices. This systematic analysis comprehensively summarises a number of related studies. Their methods, limitations, results, and other aspects are outlined in the respective sections. Conclusion: This review concludes by determining that the effectiveness of the ResQPUMP, in particular (and ACD devices in general), is promising while the ResQPOD’s is uncertain. Future studies are needed to determine whether the effectiveness of the ResQPUMP markedly diminishes when used independently of the ResQPOD. This is an important feature for fire departments and other EMS municipalities because outfitting all appropriate units with both devices can be quite costly. Further studies are also needed to demonstrate reproducibility in humans (because 2 of the studies used pigs as test subjects) and with a greater amount of test subjects.

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Section: Clinically Focusedmentioning

confidence: 83%

Section: Clinically Focusedmentioning

confidence: 99%

Section: Clinically Focusedmentioning

confidence: 99%

“…Tmax was measured in minutes [28] . Cmax is measured in nanograms of epinephrine per milliliter (ng/mL) of plasma [28] .…”

Section: Clinically Focusedmentioning

confidence: 99%

“…The Tmax was greater in the group with the ResQPod when compared to the control group that did not utilise the ResQPod. Tmax was measured in minutes[28] .…”

mentioning

confidence: 99%

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The ResQCPR System: An Objective and Systematic Review

Goodwin

Zeid

Belok

2021

ijirms

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A Review of CPR Augmentation Devices

Bengio¹,

Goodwin²,

Scumpia³

2023

Cureus

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The study aims to assess cardiopulmonary resuscitation (CPR) outcomes in cardiac arrest patients when using CPR augmentation devices, such as the ZOLL ResQCPR system (Chelmsford, MA) or its components ResQPUMP and ResQPOD, which are manual active compression-decompression (ACD) device and impedance threshold device (ITD), respectively. The analysis included a Google Scholar-based literature review that took place between January 2015 and March 2023 and included recent publications with PubMed IDs or widely cited articles to assess the effectiveness of the ResQPUMP and ResQPOD or similar devices. This review also includes studies quoted by ZOLL, but those were not considered in our conclusion since the authors were employed by ZOLL. We found that in a study on human cadavers, the force of decompression increased the chest compliance of the chest wall by 30%-50% (p<0.05). Essentially, active compressiondecompression improved the return of spontaneous circulation (ROSC) with meaningful neurologic outcomes by 50% in a blinded, randomized, and controlled human trial (n=1,653; p<0.02). The main study on the ResQPOD had a controversial human data pool with one randomized and controlled study arguing for no significant difference with or without the device (n=8,718; p=0.71). However, a post hoc analysis and the reorganization of the data by CPR quality demonstrated significance (n decreased to 2,799, reported in odds ratio without specific p-values). In conclusion to the limited number of studies presented, any manual ACD device is a great alternative to standard cardiopulmonary resuscitation regarding survivability with good neurologic function and should be utilized in prehospital emergency medical services and hospital emergency departments. ITDs are still controversial but promising with more future data.

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Effects of the ResQPod� on Maximum Concentration and Time to Maximum Concentration of Epinephrine in a Porcine Cardiac Arrest Model

Cited by 2 publications

References 20 publications

The ResQCPR System: An Objective and Systematic Review

The ResQCPR System: An Objective and Systematic Review

A Review of CPR Augmentation Devices

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