Effects of the prostacyclin analogue iloprost on cyclosporin-induced renal hypoperfusion in stable renal transplant recipients
Abstract:Background. The synthetic prostacyclin analogues have been proposed to protect against cyclosporin A (CsA) nephrotoxicity. The present study investigated the effect of infusion of the prostacyclin analogue iloprost on the acute CsA-induced renal hypoperfusion and hypofiltration in stable renal-transplant recipients. Methods. The study included 10 stable renal-transplant recipients with good graft function (s-creatinine 90-170 umol/1). Renal function and the acute renal haemodynamic and tubular response to an o… Show more
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