Effects of the preoperative use and dosage of steroids on postoperative complications of gastric cancer surgery

Ri, Motonari; Narita, Tomonori; Urabe, Masayuki; Yoshimura, Shuntaro; Yajima, Shoh; Okumura, Yasuhiro; Yagi, Koichi; Seto, Yasuyuki

doi:10.1007/s00595-023-02698-6

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The metabolic heterogeneity identified in our study could help explain these apparently contradictory findings in STAD. The consideration of whether to use steroids in stomach cancer treatment could potentially balance the likelihood of benefit from a metabolic model with findings indicating that pre-operative steroid use could complicate gastric cancer surgeries [50]. The activities of several other metabolic pathways were prognostic in various cancer types.…”

Section: Other Metabolic Trends In Survival Datamentioning

confidence: 99%

Pan-Cancer, Genome-Scale Metabolic Network Analysis of over 10,000 Patients Elucidates Relationship between Metabolism and Survival

Bucksot,

Ritchie,

Biancalana

et al. 2024

Cancers

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Despite the high variability in cancer biology, cancers nevertheless exhibit cohesive hallmarks across multiple cancer types, notably dysregulated metabolism. Metabolism plays a central role in cancer biology, and shifts in metabolic pathways have been linked to tumor aggressiveness and likelihood of response to therapy. We therefore sought to interrogate metabolism across cancer types and understand how intrinsic modes of metabolism vary within and across indications and how they relate to patient prognosis. We used context specific genome-scale metabolic modeling to simulate metabolism across 10,915 patients from 34 cancer types from The Cancer Genome Atlas and the MMRF-COMMPASS study. We found that cancer metabolism clustered into modes characterized by differential glycolysis, oxidative phosphorylation, and growth rate. We also found that the simulated activities of metabolic pathways are intrinsically prognostic across cancer types, especially tumor growth rate, fatty acid biosynthesis, folate metabolism, oxidative phosphorylation, steroid metabolism, and glutathione metabolism. This work shows the prognostic power of individual patient metabolic modeling across multiple cancer types. Additionally, it shows that analyzing large-scale models of cancer metabolism with survival information provides unique insights into underlying relationships across cancer types and suggests how therapies designed for one cancer type may be repurposed for use in others.

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Section: Other Metabolic Trends In Survival Datamentioning

confidence: 99%

Pan-Cancer, Genome-Scale Metabolic Network Analysis of over 10,000 Patients Elucidates Relationship between Metabolism and Survival

Bucksot,

Ritchie,

Biancalana

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…• Preoperative medication: corticosteroids increased the postoperative AL to 11.8% (compared to 2.1% in patients without corticosteroids) and increased with prednisone dose [31]. The nonsteroidal anti-inflammatory drugs (NSAIDs) administered preoperatively increased the rate of anastomotic and duodenal leakage compared to non-NSAIDs group (2.1% vs. 0.7%, p=0.005 and 1.5% vs. 0.4%, p=0.008, respectively) [32].…”

Section: Risk Factorsmentioning

confidence: 99%

Anastomotic Leakage after Gastrectomy for Gastric Cancer

Seicean,

Puscasu,

Gheorghiu

et al. 2023

JGLD

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Anastomotic leakage (AL) constitutes a prominent cause of significant morbidity following gastrectomy for gastric cancer. The manifestation of AL typically occurs within 7 to 10 days post-surgery, with reported incidence rates of 5.8-6.7% for open gastrectomy and 3.3-4.1% for laparoscopic gastrectomy. Various predisposing risk factors have been identified, including the individual nutritional status (excluding obesity) and preoperative corticotherapy. Interestingly, the administration of neoadjuvant therapies appears to reduce the AL occurrence. In the context of distal gastrectomies, the rates of AL are comparable between laparoscopic, robotic, and open approaches. The total gastrectomies have higher AL rate compared to distal gastrectomies, which are considered the preferred approach. Prophylactic drainage measures have not demonstrated efficacy in preventing AL. As for postoperative management, conservative treatment is indicated for patients presenting with mild clinical symptoms and increased inflammatory blood tests. This approach involves fasting, enteral or parenteral nutrition, administration of antibiotics, and percutaneous drainage. For small AL, endoscopic therapies such as stents, vacuum therapy, clips, suturing devices, and injections are appropriate treatment options. In cases of high-volume fistulas, severe sepsis or failure of previous therapies, surgical reoperation becomes the ultimate solution.

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Effects of the preoperative use and dosage of steroids on postoperative complications of gastric cancer surgery

Cited by 2 publications

References 26 publications

Pan-Cancer, Genome-Scale Metabolic Network Analysis of over 10,000 Patients Elucidates Relationship between Metabolism and Survival

Pan-Cancer, Genome-Scale Metabolic Network Analysis of over 10,000 Patients Elucidates Relationship between Metabolism and Survival

Anastomotic Leakage after Gastrectomy for Gastric Cancer

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