Effects of the Phytoestrogen Genistein on Some Predictors of Cardiovascular Risk in Osteopenic, Postmenopausal Women: A Two-Year Randomized, Double-Blind, Placebo-Controlled Study

Atteritano, Marco; Marini, Herbert; Minutoli, Letteria; Polito, Francesca; Bitto, Alessandra; Altavilla, Domenica; Mazzaferro, S.; D’Anna, Rosario; Cannata, Maria Letizia; Gaudio, Agostino; Frisina, Alessia; Frisina, N; Corrado, Francesco; Cancellieri, Francesco; Lubrano, Carla; Bonaiuto, Michele; Adamo, Elena Bianca; Squadrito, Francesco

doi:10.1210/jc.2006-2295

Cited by 158 publications

(113 citation statements)

References 43 publications

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“…It is important to note that although participants in the present study had elevated blood pressure, mean blood pressure for this group (resting or mean 24-hour) fell within the prehypertensive range. Whereas baseline CAM concentrations appeared similar to normotensive individuals, previous reports have indicated a significant reduction in CAM with isoflavone supplementation despite baseline concentrations being much lower (Atteritano et al 2007) than those observed in our participants. Also, studies that reported significant reductions typically enrolled three to four times the number of participants in comparison to the present study.…”

Section: Discussionsupporting

confidence: 48%

“…Atteritano et al (2007) supplemented postmenopausal women with 54 mg/day of genistein for 2 years and found sVCAM-1 and sICAM-1 to be significantly (P < 0.05) reduced compared to placebo. Colacurci et al (2005) supplemented postmenopausal women with an isoflavone tablet and also reported a significant reduction in CAM, including sVCAM-1, sICAM-1, and E-selectin.…”

Section: Cell Adhesion Molecule Expressionmentioning

confidence: 98%

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The Effect of Soy Protein Beverages on Serum Cell Adhesion Molecule Concentrations in Prehypertensive/Stage 1 Hypertensive Individuals

Dettmer

Alekel

Lasrado

et al. 2012

Journal of the American College of Nutrition

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Section: Discussionsupporting

confidence: 48%

Section: Cell Adhesion Molecule Expressionmentioning

confidence: 98%

The Effect of Soy Protein Beverages on Serum Cell Adhesion Molecule Concentrations in Prehypertensive/Stage 1 Hypertensive Individuals

Dettmer

Alekel

Lasrado

et al. 2012

Journal of the American College of Nutrition

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“…S7B). These findings were surprising given that resveratrol and genistein are currently being tested in clinical studies as treatments for cardiovascular disease, type 2 diabetes, osteopenia, and osteoporosis (24,25); resveratrol has gained notoriety for its potential antiaging effects; and baicalein is the major constituent of a Japanese herbal remedy for chronic hepatitis (26). The genotoxicity caused by these compounds raises concerns regarding their use for such conditions and suggests a reevaluation of their safety.…”

Section: Discussionmentioning

confidence: 99%

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death

Fox

Sakamuru

Huang

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

109

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Human ATAD5 is a biomarker for identifying genotoxic compounds because ATAD5 protein levels increase posttranscriptionally in response to DNA damage. We screened over 4,000 compounds with a cell-based quantitative high-throughput ATAD5-luciferase assay detecting genotoxic compounds. We identified 22 antioxidants, including resveratrol, genistein, and baicalein, that are currently used or investigated for the treatment of cardiovascular disease, type 2 diabetes, osteopenia, osteoporosis, and chronic hepatitis, as well as for antiaging. Treatment of dividing cells with these compounds induced DNA damage and resulted in cell death. Despite their genotoxic effects, resveratrol, genistein, and baicalein did not cause mutagenesis, which is a major side effect of conventional anticancer drugs. Furthermore, resveratrol and genistein killed multidrug-resistant cancer cells. We therefore propose that resveratrol, genistein, and baicalein are attractive candidates for improved chemotherapeutic agents.chemotherapy | high-throughput screening O ne distinctive characteristic of cancer cells is persistent cell division that requires DNA replication. This feature is often exploited to develop chemotherapeutic drugs because cancer cells are exquisitely sensitive to the inhibition of DNA replication by the introduction of DNA damage by radiation or genotoxic chemicals. DNA lesions resulting from exposure to genotoxic agents stall DNA replication, collapse replication forks, and produce DNA double-strand breaks (DSBs), resulting in cell death. If not repaired properly, many of these genomic insults can also induce gene mutations or chromosomal alterations that may make cells more resilient to cell-cycle checkpoints or apoptosis. Thus, cancer treatment may greatly benefit from the identification of genotoxic agents that kill rapidly dividing cells with minimal mutagenic side effects.ATAD5 is the homolog of yeast Enhanced Level of Genome Instability Gene 1 (ELG1), which makes a heteropentameric alternative replication factor C complex and suppresses genomic instability and tumorigenesis (1-3). ATAD5 plays a key role in the translesion synthesis (TLS) pathway where TLS polymerases are used to bypass DNA lesions that stall or collapse DNA replication forks (4, 5). In the TLS pathway, switching from replicative polymerases to TLS polymerases is promoted through the interaction between proliferating cell nuclear antigen (PCNA) monoubiquitylated at lysine 164 and an ubiquitin-binding motif in TLS polymerases, a mechanism that is conserved from yeast to humans (6). ATAD5 is stabilized and forms nuclear foci at the site of stalled replication forks in response to DNA damage (7) and appears to participate in the removal of ubiquitin from chromatinbound monoubiquitylated PCNA through its interaction with ubiquitin-specific peptidase 1 (5). The ATAD5-mediated deubiquitylation of PCNA allows lesion-bypassed TLS polymerases to switch back to replicative polymerases, and thereby prevents the low-fidelity TLS polymerases from causing harmful muta...

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“…서구 사회에서 전립선암, 유방암, 골다공증 및 심혈관계 질 환 등 호르몬 관련 질환의 유병률 이 콩의 섭취량이 많은 아시 아인에 비해 현저히 높은 것으로 여러 역학조사에서 밝혀짐에 따라 콩 섭취에 대한 관심이 고조되고 있다 [4,16,42]. 콩은 수 천년 동안 여러 아시아 지역에서 단백질의 중요한 급원 식품 으로 공급되어 왔고 [9,28,40] 또한 대두 단백질과 더불어 콩에 다량 함유된 isoflavone은 폐경기 증상을 완화시키고, 심혈관 질환, 골다공증 및 암의 위험을 감소시킨다는 연구들이 많이 보고되었다 [6,17,26].…”

Section: 서 론unclassified

Effects of Isoflavone Supplementation on Lipid Profiles and Antioxidant Systems in Rats Fed with Cholesterol Diet

Kim¹,

Kim²,

Chung³

et al. 2010

Journal of Life Science

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There is an increasing interest in the potential of isoflavone in reducing the risk of cardiovascular disease and cancer, however, although several effects of isoflavone as a component of soy protein are well established, the hypolipidemic and antioxidant effects of purified isoflavone are still controversial. This study was to investigate the effects of isoflavone on serum lipid profiles and antioxidant status in rats. 7-week old male Sprague Dawley rats were fed one of the following diets for 8 weeks: basal diet (B), basal+0.3% isoflavone (BI), basal+0.5% cholesterol (BC), or basal+0.3% isoflavone +0.5% cholesterol (BIC). Two-way ANOVA was used to test the effects of dietary isoflavone and cholesterol supplementation and their interaction on variables. Serum lipid profiles and total antioxidant status (TAS) were examined spectrophotometrically. Degree of serum lipid peroxidation was measured by malondialdehyde (MDA) assay. The activities of serum antioxidant enzymes (GSH-Px, total-SOD) was determined. Levels of serum total cholesterol, VLDL+LDL-cholesterol and Atherogenic index were significantly lower in BI than those levels in group B (p=0.0002, p<0.0001, and p=0.0042, respectively).Serum total antioxidant status (TAS) levels were significantly higher, in both isoflavone supplemented groups (BI, BIC) compared to those levels in each control group (B, BC) (p<0.0001). Activity of total-SOD was significantly higher in BI compared to the activities in group B (p=0.0317). There was no interaction between isoflavone and cholesterol supplementation. In conclusion, isoflavone supplementation showed positive effects on the serum lipid profiles and total antioxidant activities in both conditions, either when fed a diet with or without cholesterol. These effects of isoflavone were independent of cholesterol supplementation.

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Effects of the Phytoestrogen Genistein on Some Predictors of Cardiovascular Risk in Osteopenic, Postmenopausal Women: A Two-Year Randomized, Double-Blind, Placebo-Controlled Study

Abstract: These results suggest that 54 mg genistein plus calcium, vitamin D(3), and a healthy diet was associated with favorable effects on both glycemic control and some cardiovascular risk markers in a cohort of osteopenic, postmenopausal women.

Cited by 158 publications

References 43 publications

The Effect of Soy Protein Beverages on Serum Cell Adhesion Molecule Concentrations in Prehypertensive/Stage 1 Hypertensive Individuals

The Effect of Soy Protein Beverages on Serum Cell Adhesion Molecule Concentrations in Prehypertensive/Stage 1 Hypertensive Individuals

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death

Effects of Isoflavone Supplementation on Lipid Profiles and Antioxidant Systems in Rats Fed with Cholesterol Diet

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