Effects of the phthalate exposure during three gestation periods on birth weight and their gender differences: A birth cohort study in China

Zhang, Yun wei; Gao, Hui; Mao, Limin; Tao, Xing Yong; Ge, Xing; Huang, Kun; Zhu, Peng; Hao, Jia; Wang, Qu nan; Xu, Yuan; Jin, Zhong xiu; Sheng, Jie; Xu, Ye qing; Yan, Shuang; Tao, Xu Guang; Tong, Fang

doi:10.1016/j.scitotenv.2017.08.319

Cited by 47 publications

(24 citation statements)

References 29 publications

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“…Similarly, maternal MMP and MEP exposures were negatively associated with birth weight only among female infants, whereas the positive effect of MBP and MEHP on neonatal birth weight was observed only in males (93). And the adverse effect of MEHP, MEHHP, and MEOHP exposure on birth weight was stronger in male infants with low birth weight (93). Taken together, these findings suggest that exposure to certain phthalates impaired fetal growth parameters, which was modulated by fetal gender (82,85,92,93).…”

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 77%

“…Moreover, Watkins et al (85) observed maternal urinary ΣDBP (MnBP and MiBP) levels were associated with a decreased birth weight in females but associated with an increase in birth weight among males. Similarly, maternal MMP and MEP exposures were negatively associated with birth weight only among female infants, whereas the positive effect of MBP and MEHP on neonatal birth weight was observed only in males (93). And the adverse effect of MEHP, MEHHP, and MEOHP exposure on birth weight was stronger in male infants with low birth weight (93).…”

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 87%

“…There were substantial evidence that prenatal phthalate exposure results in abnormal fetal development and adverse perinatal outcome, even persisted in childhood. Those studies, examining the phthalate metabolites in maternal urine samples, maternal meconium or cord blood, reported inverse (82,84,85,(89)(90)(91)(92)(93)(94)(95)(96)(97)(98), null (68,72,79,83,99), and positive (85,97) associations between women exposed to phthalates and its fetal growth. Moreover, a few longitudinal studies (97,(100)(101)(102)(103)(104)(105)(106)(107) had assessed associations of certain phthalate exposure during pregnancy and BMI, waist circumference, and risk of overweight/obesity in childhood, and the findings were inconsistent and often sexspecific ( Table 4).…”

Section: Prenatal Phthalate Exposure and Growth Of Fetal And Childmentioning

confidence: 99%

“…HMWPm with BMI z-scores in boys HMWPm with BMI z-scores in girls (53) MiBP, MBzP, MEHP and MECPP with BMI trajectories in males MECPP with BMI trajectories in female (107) factor expression in mice (108). Most epidemiological studies in humans found that exposure to LMWP metabolites, such as MEP, MBP, MiBP, and HMWP metabolites, MEHHP, and MEOHP, were negatively related to birth weight (82,85,(89)(90)(91)(92)(93)(94)(95)(96), birth length (89,91,95), and circumferences of head, chest or abdominal (84,85,91,94,96,98). In nested case-control studies, Zhang et al found that in utero phthalate metabolite exposure (DBP in cord blood and MEHP in meconium) and maternal urinary phthalate levels (such as MMP, MBP, MEHP, MEOHP, and MEHHP) were negatively correlated with birth weight (89,90).…”

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 99%

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The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. This article aims to review the endocrine impairment and potential outcomes of prenatal phthalate exposure. Prenatal exposure phthalates would disrupt the levels of thyroid, sex hormone, and 25-hydroxyvitamin D in pregnant women or offspring, which results in preterm birth, preeclampsia, maternal glucose disorders, infant cryptorchidism, infant hypospadias, and shorter anogenital distance in newborns, as well as growth restriction not only in infants but also in early adolescence and childhood. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.

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Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 77%

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 87%

Section: Prenatal Phthalate Exposure and Growth Of Fetal And Childmentioning

confidence: 99%

Section: Prenatal Phthalate Exposure and Fetal Growthmentioning

confidence: 99%

See 2 more Smart Citations

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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“…Out of the 12 phthalate metabolites included in this analysis, MEP was most strongly associated with lower odds of LGA births both in single-pollutant models and within quantile g-computation models for the mixture of phthalate metabolites. In support of this observation, a previous prospective study reported inverse associations between maternal urinary MEP concentrations, measured repeatedly across gestation, and birth weight (52). However, the overall literature on prenatal phthalate exposure and fetal growth is inconsistent with respect to both the implicated phthalate species and the direction of effect (1).…”

Section: Discussionmentioning

confidence: 84%

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Bommarito

Welch

Keil

et al. 2020

Preprint

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Background While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. We investigated associations between prenatal exposure to 33 consumer product chemicals (nine organophosphate ester flame retardant [OPE] metabolites, 12 phthalate metabolites, and 12 phenols) and the odds of small- or large-for-gestational age (SGA and LGA) births. Methods This case-control study was comprised of SGA (N = 31), LGA (N = 28), and appropriate for gestational age control (N = 31) births selected from the larger LIFECODES cohort. Biomarkers of exposure to consumer product chemicals were quantified in maternal urine collected from up to three study visits during pregnancy. In a single-pollutant approach, odds ratios (OR) and 95% confidence intervals (CI) of SGA and LGA associated with an interquartile range (IQR)-increase in exposure biomarkers were estimated using multinomial logistic regression. In a multi-pollutant approach, quantile g-computation was used to jointly estimate the OR (95% CI) of SGA and LGA per simultaneous one quartile-change in all biomarkers belonging to each chemical class. Results Among the 33 biomarkers analyzed, 20 were detected in at least 50% of the participants. After adjusting for potential confounders, we observed reduced odds of LGA in association with higher urinary concentrations of several exposure biomarkers. For example, an IQR-increase in the OPE metabolite, diphenyl phosphate, was associated with lower odds of LGA births (OR: 0.40 [95% CI: 0.18, 0.87]). Using quantile g-computation, we estimated lower odds of an LGA birth for lower OPE metabolites (OR: 0.49 [95% CI: 0.27, 0.89]) and phthalate metabolites (OR: 0.23 [95% CI: 0.07, 0.73]). Associations between consumer product chemicals and SGA were largely null. Conclusions Joint exposure to OPEs and phthalates was associated with lower odds of delivering LGA. Associations with LGA could indicate a specific impact of these exposures on the high end of the birth weight spectrum. Future work to understand this nuance in the associations between consumer product chemical mixtures and fetal growth is warranted.

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Update about the disrupting‐effects of phthalates on the human reproductive system

Mesquita

Lorigo

Cairrão

2021

Molecular Reproduction Devel

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Phthalate esters are synthetic chemicals used in the plastic industry as plasticizers and consumable products. According to United Nations, about 400 million tons of plastic are produced every year. In parallel with increased production, the concerns about its effects on human health have increased because phthalates are endocrinedisrupting compounds. Humans are continuously exposed to phthalates through different routes of exposure. Experimental data have associated the phthalates exposure to adverse effects on development and reproduction in women (e.g., earlier puberty, primary ovarian insufficiency, endometriosis, preterm birth, or in vitro fertilization) and men (e.g., anogenital distance, cryptorchidism, hypospadias, and changes in adult reproductive function) although there is no consensus. Therefore, one question arises: could the increase in infertility be related to phthalates exposure? To answer this question, we aimed to assess the disruptingeffects of phthalates on the human reproductive system. For this, we reviewed the current literature based on epidemiological and experimental data and experimental studies in humans. The phthalate effects were discussed in a separate mode for female and male reproductive systems. In summary, phthalates induce toxicity in the reproductive system and human development. The increased plastic production may be related to the increase in human infertility.

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Effects of the phthalate exposure during three gestation periods on birth weight and their gender differences: A birth cohort study in China

Cited by 47 publications

References 29 publications

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Update about the disrupting‐effects of phthalates on the human reproductive system

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