Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity

Vinderola, Gabriel; Perdigón, Gabriela; Duarte, Júlio César; Farnworth, E. R.; Matar, Chantal

doi:10.1016/j.cyto.2007.01.003

Cited by 240 publications

(170 citation statements)

References 44 publications

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“…Cytokine production, particularly IL-10, was affected in mucosal cells (49). In a mouse model, exopolysaccharide produced by Lactobacillus kefiranofaciens could modulate immune responses (50). Furthermore, in mice infected with Salmonella enterididis, the survival of mice fed with a nonbacterial fraction of fermented milk was enhanced as compared with the control group (51).…”

Section: Animal Studiesmentioning

confidence: 87%

Fermentation products: immunological effects on human and animal models

2013

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Section: Animal Studiesmentioning

confidence: 87%

Fermentation products: immunological effects on human and animal models

2013

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“…Kefiran also exhibits a potential role in intestinal homeostasis, with an increase in luminal IgA and of both pro-and anti-inflammatory cytokines, such as IFN-c, TNFa, IL-6 and IL-10, observed in the small and large intestine (Vinderola et al, 2006). In concordance with these homeostatic effects, a study by Sengül et al (2006) demonstrated that EPS-producing bacteria were able to significantly attenuate the inflammation of an experimental colitis model, induced via intracolonic administration of acetic acid, in rats.…”

Section: Exopolysaccharidesmentioning

confidence: 99%

“…EPSs have also been suggested to play a major role in bacterial attachment (Watnick & Kolter, 1999) Kefiran, an EPS produced by a number of strains of lactobacilli in the fermented milk drink kefir, has been shown to possess a number of systemic physiological activities; these include wound-healing properties, reduction of blood pressure and cholesterol levels, and the retardation of tumour growth in experimental models (Vinderola et al, 2006). Kefiran also exhibits a potential role in intestinal homeostasis, with an increase in luminal IgA and of both pro-and anti-inflammatory cytokines, such as IFN-c, TNFa, IL-6 and IL-10, observed in the small and large intestine (Vinderola et al, 2006). In concordance with these homeostatic effects, a study by Sengül et al (2006) demonstrated that EPS-producing bacteria were able to significantly attenuate the inflammation of an experimental colitis model, induced via intracolonic administration of acetic acid, in rats.…”

Section: Exopolysaccharidesmentioning

confidence: 99%

“…Kefiran, an EPS produced by a number of strains of lactobacilli in the fermented milk drink kefir, has been shown to possess a number of systemic physiological activities; these include wound-healing properties, reduction of blood pressure and cholesterol levels, and the retardation of tumour growth in experimental models (Vinderola et al, 2006). Kefiran also exhibits a potential role in intestinal homeostasis, with an increase in luminal IgA and of both pro-and anti-inflammatory cytokines, such as IFN-c, TNFa, IL-6 and IL-10, observed in the small and large intestine (Vinderola et al, 2006).…”

Section: Exopolysaccharidesmentioning

confidence: 99%

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Exploring the immunomodulatory potential of microbial-associated molecular patterns derived from the enteric bacterial microbiota

Patten

Collett

2013

Microbiology

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The human intestinal lumen represents one of the most densely populated microbial niches in the biological world and, as a result, the intestinal innate immune system exists in a constant state of stimulation. A key component in the innate defence system is the intestinal epithelial layer, which acts not only as a physical barrier, but also as an immune sensor. The expression of pattern recognition receptors, such as Toll-like receptors, in epithelial cells allows innate recognition of a wide range of highly conserved bacterial moieties, termed microbial-associated molecular patterns (MAMPs), from both pathogenic and non-pathogenic bacteria. To date, studies of epithelial immunity have largely concentrated on inflammatory pathogenic antigens; however, this review discusses the major types of MAMPs likely to be produced by the enteric bacterial microbiota and, using data from in vitro studies, animal model systems and clinical observations, speculates on their immunomodulatory potential. IntroductionThe intestine represents the body's largest mucosal surface, with the adult human intestine estimated to cover an area of about 250 m 2 (Artis, 2008). The highly folded luminal surface of the intestinal wall significantly increases absorption efficiency and, as such, is the largest surface area of the body exposed to the environment and its high microbial load (DeSesso & Jacobson, 2001). Humans have co-evolved with indigenous microbial populations, termed microbiota, which inhabit various niches of the body (Hooper et al., 2012) and the adult intestine is one of the most densely populated microbial habitations in the biological world (Artis, 2008). The enteric microbiota predominantly consists of bacteria, with estimated populations of~10 14 bacteria, with up to 500 species represented (Gill et al., 2006;Guarner & Malagelada, 2003); however, methanogenic archaea, eukaryotes (yeasts) and viruses (mainly bacteriophages) are also present (Lozupone et al., 2012). Due to the vast expanse of intestinal tissue exposed to the microbiota, the local innate immune system is in a constant state of stimulation, and a chronic, low-level proinflammatory response is characteristic of enteric immune homeostasis (Macpherson & Harris, 2004;Artis, 2008).The intestinal epithelium plays an active role in innate immunity, and pattern recognition receptors (PRRs) are utilized to detect the presence of bacteria and their associated antigens. PRRs are germline-encoded, sensory molecules which recognize a range of highly conserved bacterial motifs, termed 'pathogen-associated molecular patterns' (PAMPs) (Medzhitov, 2001). However, the ability of PRRs to recognize these bacterial moieties is not limited to just pathogens, and so the term 'microbial-associated molecular patterns' (MAMPs) may be more accurate (Medzhitov, 2001; Sanderson & Walker, 2007) and will be used throughout this review. Epithelium-associated, enteric immune cells, such as macrophages, dendritic cells, T-cells and B-cells, differentially express two major groups of PRRs, th...

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“…health promoting beverage and source of organisms (Vinderola et al, 2006;Walsh et al, 2016). Kefir has been associated with various health benefits through examining the mechanisms (Liu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Sensory Profiles of Protein-Fortified Kefir prepared Using Edible Insects (Silkworm Pupae, Bombyx mori): A Preliminary Study

Kim¹,

Chon²,

Song³

et al. 2017

J. Milk Sci. Biotechnol.

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Bombyx mori (silkworm pupae) is a unique and biologically significant insect, which is a recognized source of high quality protein that provides all the essential amino acids required for human health. Recently, many studies have focused on various biomedical applications of B. mori proteins. The purpose of this study was to manufacture protein-fortified kefir containing different concentrations of B. mori powder according to pH and sensory evaluations. The value of the protein-fortified kefir increased but the pH decreased with increasing incubation time, indicating that the amount of B. mori powder did not affect and pH. Addition of B. mori powder also did not affect the sensory properties of overall acceptability, texture, and color compared to control group without addition of B. mori powder. However, flavor and taste were affected by increasing the amounts of B. mori powder, with a significant difference in both flavor and taste between the control and treated groups (both p<0.05). There was no significant difference in overall acceptability, texture, and color. Further studies are needed for producing kefir as a dietary supplement utilizing the functional properties of B. mori.

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Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity

Cited by 240 publications

References 44 publications

Fermentation products: immunological effects on human and animal models

Fermentation products: immunological effects on human and animal models

Exploring the immunomodulatory potential of microbial-associated molecular patterns derived from the enteric bacterial microbiota

Sensory Profiles of Protein-Fortified Kefir prepared Using Edible Insects (Silkworm Pupae, Bombyx mori): A Preliminary Study

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