Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model

Tsunemi, Sachi; Iwasaki, Tsuyoshi; Kitano, S; Imado, Takehito; Miyazawa, Keiji; Sano, Hajime

doi:10.1016/j.clim.2010.03.428

Cited by 72 publications

(56 citation statements)

References 31 publications

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“…Additionally, disease progression was retarded in arthritic SKG mice injected with anti-CD4 mAbs [40]. FTY720 is a high-affinity agonist for sphingosine 1-phosphate receptors which exerts its immunomodulatory effects by sequestration of lymphocytes within the thymus and secondary lymphoid organs, therefore preventing them from recirculating to the periphery [41,42]. In b-glucan-induced arthritis, development of disease in SKG mice was inhibited by FTY720 treatment because CD4 + T cells specifically accumulate in the thymus and are prevented from access to joints and other peripheral organs.…”

Section: The Role Of Cd4 + T Cells In Disease Inductionmentioning

confidence: 99%

Effector T cells in rheumatoid arthritis: Lessons from animal models

Alzabin

Williams

2011

FEBS Letters

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The development of an immune response to self antigens drives naive T cells to differentiate into subsets of CD8+ and CD4+ effector cells including TH1, TH2, cells and the more recently described TH17, and regulatory T cells (Treg). Rheumatoid arthritis is an autoimmune disease that engages an uncontrolled influx of inflammatory cells to the joints, eventually leading to joint damage. The role that effector T cells play in the local or systemic maintenance of, or protection against, inflammation and subsequent joint damage is now becoming better understood through the use of animal models. In this review, we will explore the different animal models of RA, and their contribution to elucidating the role that effector T cells play in the regulation, induction, and maintenance of inflammatory joint disease. This understanding will aid in the design of more effective therapeutic strategies for rheumatoid arthritis and other autoimmune disorders.

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Section: The Role Of Cd4 + T Cells In Disease Inductionmentioning

confidence: 99%

Effector T cells in rheumatoid arthritis: Lessons from animal models

Alzabin

Williams

2011

FEBS Letters

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“…FTY720 administration suppresses the progression of laminarin-induced arthritis in the SKG mice [130]. FTY720 treatment decreases IL-6 and TNF-α expression in synovial fibroblasts and inflammatory cells, as well as bone destruction.…”

Section: Targeting S1p Receptors: S1p Receptor Agonist Fty720mentioning

confidence: 95%

Sphingosine-1-Phosphate and Rheumatoid Arthritis: Pathological Implications and Potential Therapeutic Targets

Zhang¹,

Chang²

2013

Innovative Rheumatology

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“…In vivo Fitzpatrick et al, 2011 siSphK1 Reduces S1P formation Down-regulates S1PRs and renders cells unresponsive to S1P S1P1, S1P3, S1P4 and S1P5 Matsuura et al, 2000;Tsunemi et al;Wang et al, 2007 VPC23019 (S1P1/3 antagonist), CAY10444 (S1P3 antagonist) and JTE-013 (S1P2 antagonist)…”

Section: Sphk2mentioning

confidence: 99%

“…FTY-720 was recently FDA-approved for the treatment of multiple sclerosis (Strader et al, 2011). The effects of FTY-720 have been examined in several animal models of arthritis (Matsuura et al, 2000;Tsunemi et al, 2010;Wang et al, 2007). In the study of Wang et al (2007), CIA rats were treated daily with FTY-720 for 28 days and the arthritis index was measured.…”

Section: S1p Receptor Agonists Fty-720mentioning

confidence: 99%