Effects of the New Anti-Ulcer Drug Ecabet Sodium (TA-2711) on Pepsin Activity I. Inactivation of Enzyme Protein

Ito, Yutaka; Nakamura, Susumu; Onoda, Yuichi; Sugawara, Yoichi; Takaiti, Osasi

doi:10.1254/jjp.61.333

Cited by 4 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some in vitro studies have sought to determine the contribution of AMPA receptors [9] and other classes of glutamate receptors [10] to postsynaptic potentials using pharmacological isolation techniques. Another in vitro work analyzed the contribution of AMPA, NMDA, and GABA A receptors to temporal patterns in PSPs of the inferior colliculus of the rat [11].…”

Section: Previous Workmentioning

confidence: 99%

Characterizing Neurotransmitter Receptor Activation with a Perturbation Based Decomposition Method

Jue¹

View full text Add to dashboard Cite

Section: Previous Workmentioning

confidence: 99%

Characterizing Neurotransmitter Receptor Activation with a Perturbation Based Decomposition Method

Jue¹

View full text Add to dashboard Cite

Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons

et al. 1998

View full text Add to dashboard Cite

Effects of the COX-2 Inhibitor FK3311 on Ischemia—Reperfusion Injury in the Rat Lung

Otani

Takeyoshi

Yoshinari

et al. 2007

Journal of Investigative Surgery

View full text Add to dashboard Cite

Ischemia-reperfusion injury is induced by activation of the arachidonic acid cascade following the induction of cyclooxygenase-2. This study evaluated the effects of a selective cyclooxygenase-2 inhibitor, FK3311, on warm ischemia-reperfusion injury in the lung. Male Wistar rats were divided into two groups. In the FK3311 group (n = 27), FK3311 (4 mg/kg) was administered intravenously 5 min before ischemia, while in the control group (n = 27) only vehicle was injected. Warm ischemia was induced for 1 h by clamping the left hilus. The arterial oxygen pressure (PaO(2)) and saturation (SaO(2)) were measured 30 and 120 min after reperfusion. Serum thromboxane B(2) and 6-keto-prostaglandin F(1alpha) were also measured 30 min after reperfusion. Lung specimens were harvested 120 min after reperfusion for histologic examination and polymorphonuclear counts, and immunostained with cyclooxygenase-2. The 1-week survival rate in the two groups was compared. PaO(2) and SaO(2) 30 and 120 min after reperfusion were significantly (p < .05) better in the FK3311 group. Serum thromboxane B(2) levels were significantly (p < .05) lower in the FK3311 group. However, there was no significant difference in 6-keto-prostaglandin F(1alpha). Histologically, tissue damage was mild and polymorphonuclear infiltration was reduced in the FK3311 group compared to the control group. The expression of cyclooxygenase-2 in the alveolar epithelium based on immunostaining was suppressed in the FK3311 group. The 1-week survival rate was significantly (p < .05) higher in the FK3311 group. We conclude that FK3311 has protective effects on pulmonary ischemia-reperfusion injury, and results in improvement in the 1-week survival rate.

show abstract

Effects of the New Anti-Ulcer Drug Ecabet Sodium (TA-2711) on Pepsin Activity I. Inactivation of Enzyme Protein

Cited by 4 publications

References 26 publications

Characterizing Neurotransmitter Receptor Activation with a Perturbation Based Decomposition Method

Characterizing Neurotransmitter Receptor Activation with a Perturbation Based Decomposition Method

Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons

Effects of the COX-2 Inhibitor FK3311 on Ischemia—Reperfusion Injury in the Rat Lung

Contact Info

Product

Resources

About