Effects of the nerve agent VX on hiPSC-derived motor neurons
Catherine Schaefers,
Wolfgang Schmeißer,
Harald John
et al.
Abstract:Poisoning with the organophosphorus nerve agent VX can be life-threatening due to limitations of the standard therapy with atropine and oximes. To date, the underlying pathomechanism of VX affecting the neuromuscular junction has not been fully elucidated structurally. Results of recent studies investigating the effects of VX were obtained from cells of animal origin or immortalized cell lines limiting their translation to humans. To overcome this limitation, motor neurons (MN) of this study were differentiate… Show more
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