Effects of the LHPP gene polymorphism on the functional and structural changes of gray matter in major depressive disorder

Cui, Lingling; Wang, Fei; Zhang, Yin; Chang, Miao; Song, Yumeng; Wei, Yange; Lv, Jing; Zhang, Yifan; Tang, Yanqing; Gong, Xiaohong; Xu, Ke

doi:10.21037/qims.2019.12.01

Cited by 16 publications

(7 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides mood changes, depression is also associated with widespread reductions in gray matter in regions including the DLPFC 14 , 15 , 40 , cingulate cortex (including the anterior 14 , 15 , 41 , posterior 40 , 41 and subgenual 42 cingulate cortices), hippocampus, thalamus, and amygdala 14 , 15 , 26 , 43 . Our primary analysis indicated that HD tDCS treatment induces significant gray matter increases at the left DLPFC brain region.…”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation (tDCS) in depression induces structural plasticity

Jog

Anderson

Kubicki

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique involving administration of well-tolerated electrical current to the brain through scalp electrodes. TDCS may improve symptoms in neuropsychiatric disorders, but mixed results from recent clinical trials underscore the need to demonstrate that tDCS can modulate clinically relevant brain systems over time in patients. Here, we analyzed longitudinal structural MRI data from a randomized, double-blind, parallel-design clinical trial in depression (NCT03556124, N = 59) to investigate whether serial tDCS individually targeted to the left dorso-lateral prefrontal cortex (DLPFC) can induce neurostructural changes. Significant (FWEc p < 0.05) treatment-related gray matter changes were observed with active high-definition (HD) tDCS relative to sham tDCS within the left DLPFC stimulation target. No changes were observed with active conventional tDCS. A follow-up analysis within individual treatment groups revealed significant gray matter increases with active HD-tDCS in brain regions functionally connected with the stimulation target, including the bilateral DLPFC, bilateral posterior cingulate cortex, subgenual anterior cingulate cortex, and the right hippocampus, thalamus and left caudate brain regions. Integrity of blinding was verified, no significant differences in stimulation-related discomfort were observed between treatment groups, and tDCS treatments were not augmented by any other adjunct treatments. Overall, these results demonstrate that serial HD-tDCS leads to neurostructural changes at a predetermined brain target in depression and suggest that such plasticity effects may propagate over brain networks.

show abstract

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation (tDCS) in depression induces structural plasticity

Jog

Anderson

Kubicki

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“… 55 Search according to NCBI conserved domain database (CDD) ( https://www.ncbi.nlm.nih.gov/cdd ), HDHD2 belongs to the HAD-like hydrolase superfamily structurally and is found to be similar to phospholysine phosphohistidine inorganic pyrophosphate phosphatase ( LHPP ), which is known to associated with depression. 56 Sleep abnormalities are one of the critical symptoms of depression. 57 However, its function is not completely understood.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study and Genetic Correlation Scan Provide Insights into Its Genetic Architecture of Sleep Health Score in the UK Biobank Cohort

Yao¹,

Jia²,

Wen³

et al. 2022

NSS

View full text Add to dashboard Cite

Most previous genetic studies of sleep behaviors were conducted individually, without comprehensive consideration of the complexity of various sleep behaviors. Our aim is to identify the genetic architecture and potential biomarker of the sleep health score, which more powerfully represents overall sleep traits. Patients and Methods: We conducted a genome-wide association study (GWAS) of sleep health score (overall assessment of sleep duration, snoring, insomnia, chronotype, and daytime dozing) using 336,463 participants from the UK Biobank. Proteome-wide association study (PWAS) and transcriptome-wide association study (TWAS) were then performed to identify candidate genes at the protein and mRNA level, respectively. We finally used linkage disequilibrium score regression (LDSC) to estimate the genetic correlations between sleep health score and other functionally relevance traits. Results: GWAS identified multiple variants near known candidate genes associated with sleep health score, such as MEIS1, FBXL13, MED20 and SMAD5. HDHD2 (P PWAS = 0.0146) and GFAP (P PWAS = 0.0236) were identified associated with sleep health score by PWAS. TWAS identified ORC4 (P TWAS = 0.0212) and ZNF732 (P TWAS = 0.0349) considering mRNA expression level. LDSC found significant genetic correlations of sleep health score with 3 sleep behaviors (including insomnia, snoring, dozing), 4 psychiatry disorders (major depressive disorder, attention deficit/hyperactivity disorder, schizophrenia, autism spectrum disorder), and 9 plasma protein (such as Stabilin-1, Stromelysin-2, Cytochrome c) (all LDSC P LDSC < 0.05). Conclusion: Our results advance the comprehensive understanding of the aetiology and genetic architecture of the sleep health score, refine the understanding of the relationship of sleep health score with other traits and diseases, and may serve as potential targets for future mechanistic studies of sleep phenotype.

show abstract

“…Based on GWAS studies, LHPP. has also been implicated in major depressive disorders [133][134][135], alcohol dependence, and risky behavior [136]. A confirmed substrate for LHPP.…”

Section: Histidine Phosphatasesmentioning

confidence: 93%

NME/NM23/NDPK and Histidine Phosphorylation

Adam

Ning

Reina

et al. 2020

IJMS

View full text Add to dashboard Cite

The NME (Non-metastatic) family members, also known as NDPKs (nucleoside diphosphate kinases), were originally identified and studied for their nucleoside diphosphate kinase activities. This family of kinases is extremely well conserved through evolution, being found in prokaryotes and eukaryotes, but also diverges enough to create a range of complexity, with homologous members having distinct functions in cells. In addition to nucleoside diphosphate kinase activity, some family members are reported to possess protein-histidine kinase activity, which, because of the lability of phosphohistidine, has been difficult to study due to the experimental challenges and lack of molecular tools. However, over the past few years, new methods to investigate this unstable modification and histidine kinase activity have been reported and scientific interest in this area is growing rapidly. This review presents a global overview of our current knowledge of the NME family and histidine phosphorylation, highlighting the underappreciated protein-histidine kinase activity of NME family members, specifically in human cells. In parallel, information about the structural and functional aspects of the NME family, and the knowns and unknowns of histidine kinase involvement in cell signaling are summarized.

show abstract

Effects of the LHPP gene polymorphism on the functional and structural changes of gray matter in major depressive disorder

Cited by 16 publications

References 73 publications

Transcranial direct current stimulation (tDCS) in depression induces structural plasticity

Transcranial direct current stimulation (tDCS) in depression induces structural plasticity

Genome-Wide Association Study and Genetic Correlation Scan Provide Insights into Its Genetic Architecture of Sleep Health Score in the UK Biobank Cohort

NME/NM23/NDPK and Histidine Phosphorylation

Contact Info

Product

Resources

About