Abstract:Naltrexone (NTX) is a nonspecific opioid antagonist that binds to mu‐, kappa‐, and delta‐opioid receptors. Previous research has demonstrated that rats given chronic, intermittent sucrose access have increased endorphin function. We have shown that rats given chronic, intermittent sucrose can discriminate 1.0 mg/kg NTX from saline in a two‐lever, operant choice procedure. We wondered if NTX's discriminative stimulus effects were mediated by kappa‐opioid receptors. To examine this possibility, we tested the eff… Show more
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