Effects of the interleukin-1β-511 C/T gene polymorphism on the risk of gastric cancer in the context of the relationship between race and H. pylori infection: a meta-analysis of 20,000 subjects

Park, Min Jeong; Hyun, Myung Han; Yang, Jong Pill; Yoon, Jeong Min

doi:10.1007/s11033-014-3748-7

Cited by 18 publications

(14 citation statements)

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“…Our study did not find significant association between polymorphisms in IL12B or IL10 genes with GC risk. Our results support the previous data to other populations, which analyzed associations between SNPs in genes regulating the inflammatory response and GC[30-32,34]. …”

Section: Discussionsupporting

confidence: 92%

“…To date, different gene polymorphism related to inflammatory pathways have been evaluated, with IL-1B and IL-1RN being the most widely studied ones[18,30-34]. Computational analysis tools that we used in our study suggested two genes polymorphisms - IL12B (rs1368439) and IL10 (rs3024498) - situated in inflammatory pathways, that might be the involved in miRNA-target gene interaction[16].…”

Section: Discussionmentioning

confidence: 99%

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Polymorphisms of microRNA target genesIL12B,INSR,CCND1andIL10in gastric cancer

Petkevičius¹,

Šaltenienė²,

Juzėnas³

et al. 2017

WJG

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AIMTo evaluate associations between miRNA target genes IL12B, INSR, CCND1 and IL10 polymorphisms and gastric cancer (GC) in European population.METHODSGene polymorphisms were analyzed in 508 controls and 474 GC patients from 3 tertiary centers in Germany, Lithuania and Latvia. Controls were patients from the out-patient departments, who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy. Gastric cancer (GC) patients had histopathological verification of gastric adenocarcinoma. Genomic DNA was extracted using salting out method from peripheral blood mononuclear cells. IL12B T>G (rs1368439), INSR T>C (rs1051690), CCND1 A>C (rs7177) and IL10 T>C (rs3024498) SNPs were genotyped by the real-time polymerase chain reaction. Associations between gene polymorphism and GC were evaluated using multiple logistic regression analysis with adjustment for sex, age and country of birth.RESULTSWe observed similar distribution of genotypes and allelic frequencies of all polymorphisms between GC patients and controls except of INSR rs1051690. The frequency of the T allele of INSR gene was significantly higher in GC patients than in controls (23.26% and 19.19% respectively, P = 0.028). CT genotype was also more prevalent in patients compared to control group (38.48% and 30.12% respectively, P < 0.021). Logistic regression analysis revealed that only one polymorphism (rs1051690 in INSR gene) was associated with increased risk of GC. Carriers of CT genotype had higher odds of GC when compared to CC genotype (OR = 1.45, 95%PI: 1.08-1.95, P = 0.01). Similar association was observed in a dominant model for INSR gene, where comparison of TT+CT vs CC genotypes showed an increased risk of GC (OR = 1.44, 95%PI: 1.08-1.90, P = 0.01). Other analyzed SNPs were not associated with the presence of GC.CONCLUSIONINSR rs1051690 SNP is associated with increased risk of GC, while polymorphisms in IL12B, CCND1 and IL10 genes are not linked with the presence of GC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Polymorphisms of microRNA target genesIL12B,INSR,CCND1andIL10in gastric cancer

Petkevičius¹,

Šaltenienė²,

Juzėnas³

et al. 2017

WJG

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“…pylori infection reinforces the relation between IL-1β-511 T allele with susceptibility to gastric cancer[OR = 2.04, 95%CI = 1.15–3.62 for recessive model], which means H . pylori infection as a risk factor might have synergistic effect with IL-1B-511T allele the development of GC[28]. However, it exists a high Heterogeneity[P<0.0001, I 2 = 84%].…”

Section: Discussionmentioning

confidence: 99%

“…Caleman Neto A et al [24] revealed that it was IL-8-251T/A polymorphism associated with H . pylori infection instead of IL-1B-511 C/T polymorphisms, but Park MJ [28] suggested that H . pylori infection might increase the association between IL-1B-511C/T and stomach carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: A meta-analysis

et al. 2017

PLoS ONE

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ObjectivesThe aim of this study is to clarify the associations between IL-1B31C/T, IL-1B-511C/T, IL-8-251T/A gene polymorphisms and the risk of Helicobacter pylori (H. pylori) infection together with H. pylori-related gastric cancer (GC), peptic ulcer disease (PUD).MethodsAll eligible literature published up to July 2016 were identified by searching Pubmed, Embase, Web of Science and CNKI. Pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated using a fixed or random effects model.Results29 case-control studies were eligible, and each of them may focus on more than one gene polymorphism. Ultimately, there were 21 studies (3159 cases and 2816 controls) for IL-1B-31C/T, 16 studies (2486 cases and 1989 controls) for IL-1B-511C/T polymorphisms, 9 studies (1963 cases and 1205 controls) for IL-8-251T/A polymorphisms. Overall, an increased risk of H. pylori infection was found for IL-1B-31C/T polymorphisms in total population [OR = 1.134, 95%CI = 1.008–1.275 for recessive model; OR = 1.145, 95%CI = 1.007–1.301 for TT vs CC model]. While, for IL-1B-511C/T and IL8-251T/A polymorphisms, no evidence indicated that they were associated with the risk of H. pylori infection in all genetic models. Furthermore, we found an increased risk of H. pylori-related GC with IL-1B-511C/T polymorphisms [OR = 1.784, 95%CI = 1.289–2.469 for recessive model; OR = 1.772, 95%CI = 1.210–2.594 for TT vs CC model] and IL8-251A/T polymorphisms [OR = 1.810, 95%CI = 1.229–2.667 for recessive model; OR = 1.717, 95%CI = 1.143–2.580 for TT vs AA model], an increased risk of H. pylori-related PUD with IL8-251T/A polymorphisms [OR = 1.364, 95%CI = 1.010–1.843 for recessive model; OR = 1.427, 95%CI = 1.039–1.959 for AA vs TT model].ConclusionsIL-1B-31C/T gene polymorphisms might increase H. pylori infection risk. IL-1B-511-C/T and IL-8-251T/A gene polymorphisms might act as a risk factor to H. pylori-related diseases including GC or PUD

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“…A very recent meta-analysis reported similar correlation where the T/T genotype of IL-1β-31 increased GC risk only in individuals with H. pylori infection (table 1) [51]. A meta-analysis of IL-1β-551C/T included 45 studies and showed that the T/T genotype could evaluate GC risk in subjects with H. pylori infection (OR: 1.70; 95% CI: 1.03-2.80; I 2 = 85%) (table 1) [52]. However, a meta-analysis on the IL1-RN VNTR polymorphism and GC risk showed that the IL1-RN*2 allele was associated with higher GC risk but independent of H. pylori infection (table 1) [53].…”

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confidence: 99%

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

et al. 2016

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Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive.

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Effects of the interleukin-1β-511 C/T gene polymorphism on the risk of gastric cancer in the context of the relationship between race and H. pylori infection: a meta-analysis of 20,000 subjects

Cited by 18 publications

References 59 publications

Polymorphisms of microRNA target genesIL12B,INSR,CCND1andIL10in gastric cancer

Polymorphisms of microRNA target genesIL12B,INSR,CCND1andIL10in gastric cancer

Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: A meta-analysis

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

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